HitPredict

Interactor 1: FCG2B (P31994)
Low affinity immunoglobulin gamma Fc region receptor II-b (IgG Fc receptor II-b) (CDw32) (Fc-gamma RII-b) (Fc-gamma-RIIb) (FcRII-b) (CD antigen CD32)
Gene: FCGR2B

Interactor 2: CRK (P46108)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	17474147
Identification Methods	peptide array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0046330 - positive regulation of JNK cascade
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 310 Hs			1 304
+	Hs
		685213 FCG2C_HUMAN (1-310): 1.99e-62: 202: 83.92		CRK_HUMAN (1-304): 7.82e-68: 215: 100.00
+	Hs
		580945 FCG2B_HUMAN (1-310): 7.03e-74: 231: 100.00		PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39
+	Hs
		685205 FCG2B_HUMAN (1-310): 7.03e-74: 231: 100.00		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		580946 FCG2C_HUMAN (1-310): 1.99e-62: 202: 83.92		PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39
+	Hs
		685214 FCG2C_HUMAN (1-310): 1.99e-62: 202: 83.92		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		557621 FCG2B_HUMAN (1-310): 7.03e-74: 231: 100.00		NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00
+	Hs
		519376 FCG2A_HUMAN (38-310): 3.57e-58: 191: 73.29		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		519329 FCGR1_HUMAN (5-285): 9.76e-21: 92.9: 12.25		CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07
+	Hs
		557622 FCG2C_HUMAN (1-310): 1.99e-62: 202: 83.92		NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00
+	Mm
		722902 CD22_MOUSE (3-308): 2.01e-25: 108: 14.96		PLCG1_MOUSE (2-302): 1.1e-26: 112: 15.43
+	Mm
		722901 CD22_MOUSE (3-308): 2.01e-25: 108: 14.96		GRB2_MOUSE (135-297): 1.43e-25: 103: 15.67
+	Hs
		855816 TITIN_HUMAN (100-243): 6.17e-09: 59.4: 12.42		VAV2_HUMAN (2-191): 3.44e-29: 119: 19.74
+	Hs
		580919 CD22_HUMAN (92-310): 1.59e-09: 60.9: 13.33		PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39
+	Hs
		924597 MYLK_HUMAN (49-129): 7.38e-12: 68.3: 13.83		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Ce
		136804 UNC89_CAEEL (3-128): 4.49e-12: 69: 10.95		VAV_CAEEL (13-194): 4.87e-22: 98.4: 23.94
+	Hs
		924478 PGBM_HUMAN (130-247): 1.08e-09: 61.7: 12.50		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		590607 CD22_HUMAN (92-310): 1.59e-09: 60.9: 13.33		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		209143 FCRL2_HUMAN (52-217): 1.22e-13: 72.9: 19.89		NCK2_HUMAN (2-100): 3.06e-11: 65.2: 18.00
+	Hs
		557704 MYLK_HUMAN (49-129): 7.38e-12: 68.3: 13.83		NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00