HitPredict

Interactor 1: ARRB2 (P32121)
Beta-arrestin-2 (Arrestin beta-2) (Non-visual arrestin-3)
Gene: ARRB2

Interactor 2: PE2R4 (P35408)
Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor)
Gene: PTGER4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	11418617
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	7tm_1~Arrestin_C, 7tm_1~Arrestin_N
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 409 Hs			1 488
+	Hs
		723237 ARRB1_HUMAN (1-407): 0: 661: 76.15		PE2R4_HUMAN (1-488): 1.97e-100: 312: 100.00
+	Hs
		428933 ARRB2_HUMAN (1-409): 0: 688: 100.00		ADRB2_HUMAN (13-352): 1.09e-78: 253: 16.47
+	Hs
		685831 ARRB2_HUMAN (1-409): 0: 688: 100.00		PE2R2_HUMAN (20-370): 1.17e-79: 253: 30.96
+	Rn
		663954 ARRB2_RAT (1-409): 0: 682: 95.85		Q8VBU7_RAT (13-393): 2.08e-80: 257: 16.54
+	Hs
		656989 ARRB2_HUMAN (1-409): 0: 688: 100.00		5HT2A_HUMAN (1-395): 6.05e-76: 248: 16.75
+	Hs
		441648 ARRB2_HUMAN (1-409): 0: 688: 100.00		ADRB1_HUMAN (1-365): 1.96e-74: 244: 17.90
+	Hs
		600867 ARRB2_HUMAN (1-409): 0: 688: 100.00		TA2R_HUMAN (7-340): 4.83e-72: 233: 23.70
+	Hs
		208441 ARRB2_HUMAN (1-409): 0: 688: 100.00		OX1R_HUMAN (34-396): 8.09e-69: 228: 14.48
+	Hs
		793171 ARRB1_HUMAN (1-407): 0: 661: 76.15		PE2R2_HUMAN (20-370): 1.17e-79: 253: 30.96
+	Hs
		827197 ARRB1_HUMAN (1-407): 0: 661: 76.15		MTR1L_HUMAN (7-477): 3.01e-76: 252: 15.09
+	Hs
		441649 ARRB1_HUMAN (1-407): 0: 661: 76.15		ADRB1_HUMAN (1-365): 1.96e-74: 244: 17.90
+	Hs
		208444 ARRB1_HUMAN (1-407): 0: 661: 76.15		OX1R_HUMAN (34-396): 8.09e-69: 228: 14.48