Protein: OTX1
Homeobox protein OTX1 (Orthodenticle homolog 1)

Gene: OTX1
Organism: Homo sapiens
Interactions: 162
UniProt ID: P32242

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

733199

MDFI
MyoD family inhibitor

6

2

High-throughput

0.738

High

303108

RGS20
Regulator of G-protein signaling 20

5

3

High-throughput

0.720

High

733194

RBPMS
RNA-binding protein with multiple splicing

3

3

High-throughput

0.688

High

733230

RGS17
Regulator of G-protein signaling 17

3

2

High-throughput

0.675

High

705250

GRN
Progranulin

5

1

High-throughput

0.662

High

733200

KR412
Keratin-associated protein 4-12

4

20

High-throughput

0.644

High

221089

SPY2
Protein sprouty homolog 2

2

3

High-throughput

0.640

High

733128

KRT81
Keratin, type II cuticular Hb1

4

5

High-throughput

0.639

High

733104

COMP
Cartilage oligomeric matrix protein

4

5

High-throughput

0.637

High

733213

KRA32
Keratin-associated protein 3-2

4

4

High-throughput

0.637

High

733103

HXA1
Homeobox protein Hox-A1

1

20

High-throughput

0.621

High

733115

KR109
Keratin-associated protein 10-9

3

20

High-throughput

0.619

High

733158

LCE1B
Late cornified envelope protein 1B

3

1

High-throughput

0.617

High

685812

KRA59
Keratin-associated protein 5-9

3

20

High-throughput

0.616

High

733107

KR122
Keratin-associated protein 12-2

3

20

High-throughput

0.616

High

733114

KR108
Keratin-associated protein 10-8

3

20

High-throughput

0.616

High

733205

KRA92
Keratin-associated protein 9-2

3

20

High-throughput

0.616

High

733206

KR411
Keratin-associated protein 4-11

3

20

High-throughput

0.616

High

733212

KRA33
Keratin-associated protein 3-3

3

4

High-throughput

0.616

High

74109

VWC2L
von Willebrand factor C domain-containing protein 2-like

3

7

High-throughput

0.613

High

733166

TENS2
Tensin-2

3

7

High-throughput

0.613

High

733183

KRA13
Keratin-associated protein 1-3

3

20

High-throughput

0.613

High

733216

KRA15
Keratin-associated protein 1-5

3

20

High-throughput

0.613

High

74330

ZBT42
Zinc finger and BTB domain-containing protein 42

2

8

High-throughput

0.606

High

733124

ARI5A
AT-rich interactive domain-containing protein 5A

2

20

High-throughput

0.606

High

733131

TRIP6
Thyroid receptor-interacting protein 6

2

3

High-throughput

0.606

High

733134

OBF1
POU domain class 2-associating factor 1

2

1

High-throughput

0.606

High

733154

UBAP2
Ubiquitin-associated protein 2

2

20

High-throughput

0.606

High

733164

FHL5
Four and a half LIM domains protein 5

2

6

High-throughput

0.606

High

733195

SMIP9
Protein SPMIP9

2

1

High-throughput

0.606

High

733224

PLS2
Phospholipid scramblase 2

2

4

High-throughput

0.606

High

733227

WWOX
WW domain-containing oxidoreductase

2

1

High-throughput

0.606

High

733234

ZN330
Zinc finger protein 330

2

1

High-throughput

0.606

High

733174

ATL4
ADAMTS-like protein 4

3

1

High-throughput

0.604

High

733163

LCE2D
Late cornified envelope protein 2D

2

2

High-throughput

0.583

High

733137

NDUF6
NADH dehydrogenase

2

0

High-throughput

0.580

High

733159

INT11
Integrator complex subunit 11

2

0

High-throughput

0.580

High

733173

GASP3
G protein-coupled receptor associated sorting protein 3

2

0

High-throughput

0.580

High

733192

PCSK5
Proprotein convertase subtilisin/kexin type 5

2

0

High-throughput

0.580

High

733211

KRA42
Keratin-associated protein 4-2

2

20

High-throughput

0.578

High

221320

SPY1
Protein sprouty homolog 1

2

3

High-throughput

0.573

High

733193

SMRC1
SWI/SNF complex subunit SMARCC1

1

20

High-throughput

0.573

High

733229

FBLN5
Fibulin-5

1

5

High-throughput

0.573

High

733112

KR105
Keratin-associated protein 10-5

2

20

High-throughput

0.558

High

733116

KR10B
Keratin-associated protein 10-11

2

20

High-throughput

0.558

High

50321

F168B
Myelin-associated neurite-outgrowth inhibitor

2

2

High-throughput

0.553

High

70132

CRTP1
Cysteine-rich tail protein 1

2

2

High-throughput

0.553

High

192065

PA2GX
Group 10 secretory phospholipase A2

2

1

High-throughput

0.553

High

300633

KRT37
Keratin, type I cuticular Ha7

2

10

High-throughput

0.553

High

335349

CCN4
CCN family member 4

2

1

High-throughput

0.553

High

351509

FBLN4
EGF-containing fibulin-like extracellular matrix protein 2

2

6

High-throughput

0.553

High

506778

NHLC4
NHL-repeat-containing protein 4

2

1

High-throughput

0.553

High

694311

CO8A1
Collagen alpha-1(VIII) chain

2

3

High-throughput

0.553

High

733105

RGS19
Regulator of G-protein signaling 19

2

3

High-throughput

0.553

High

733106

KR121
Keratin-associated protein 12-1

2

2

High-throughput

0.553

High

733108

KR123
Keratin-associated protein 12-3

2

2

High-throughput

0.553

High

733113

KR107
Keratin-associated protein 10-7

2

20

High-throughput

0.553

High

733121

KRT85
Keratin, type II cuticular Hb5

2

5

High-throughput

0.553

High

733122

FBLN2
Fibulin-2

2

5

High-throughput

0.553

High

733125

KRA11
Keratin-associated protein 1-1

2

20

High-throughput

0.553

High

733129

LASP1
LIM and SH3 domain protein 1

2

5

High-throughput

0.553

High

733130

K1H1
Keratin, type I cuticular Ha1

2

10

High-throughput

0.553

High

733133

S15A2
Solute carrier family 15 member 2

2

1

High-throughput

0.553

High

733135

VWC2
Brorin

2

7

High-throughput

0.553

High

733139

KRA61
Keratin-associated protein 6-1

2

2

High-throughput

0.553

High

733140

KRA62
Keratin-associated protein 6-2

2

2

High-throughput

0.553

High

733145

KR133
Keratin-associated protein 13-3

2

6

High-throughput

0.553

High

733146

KR197
Keratin-associated protein 19-7

2

3

High-throughput

0.553

High

733148

KR132
Keratin-associated protein 13-2

2

6

High-throughput

0.553

High

733149

KLH26
Kelch-like protein 26

2

2

High-throughput

0.553

High

733152

CJ055
Uncharacterized protein C10orf55

2

1

High-throughput

0.553

High

733156

LCE1C
Late cornified envelope protein 1C

2

1

High-throughput

0.553

High

733162

LCE2C
Late cornified envelope protein 2C

2

2

High-throughput

0.553

High

733168

KR511
Keratin-associated protein 5-11

2

20

High-throughput

0.553

High

733170

KRA54
Keratin-associated protein 5-4

2

18

High-throughput

0.553

High

733171

KRA53
Keratin-associated protein 5-3

2

20

High-throughput

0.553

High

733175

CRDL2
Chordin-like protein 2

2

3

High-throughput

0.553

High

733182

KRA71
Keratin-associated protein 7-1

2

2

High-throughput

0.553

High

733184

TRI42
Tripartite motif-containing protein 42

2

15

High-throughput

0.553

High

733187

M1AP
Meiosis 1 arrest protein

2

2

High-throughput

0.553

High

733191

KRT35
Keratin, type I cuticular Ha5

2

10

High-throughput

0.553

High

733202

KRA98
Keratin-associated protein 9-8

2

20

High-throughput

0.553

High

733204

KRA93
Keratin-associated protein 9-3

2

20

High-throughput

0.553

High

733207

KRA41
Keratin-associated protein 4-1

2

20

High-throughput

0.553

High

733209

KRA45
Keratin-associated protein 4-5

2

20

High-throughput

0.553

High

733210

KRA44
Keratin-associated protein 4-4

2

20

High-throughput

0.553

High

733214

KRA31
Keratin-associated protein 3-1

2

4

High-throughput

0.553

High

733219

SPY4
Protein sprouty homolog 4

2

3

High-throughput

0.553

High

733222

CFA68
Cilia- and flagella-associated protein 68

2

1

High-throughput

0.553

High

733223

NECT3
Nectin-3

2

1

High-throughput

0.553

High

733225

ANR10
Ankyrin repeat domain-containing protein 10

2

9

High-throughput

0.553

High

733232

PP13
Galactoside-binding soluble lectin 13

2

1

High-throughput

0.553

High

733110

KR101
Keratin-associated protein 10-1

2

20

High-throughput

0.533

High

733161

LCE2A
Late cornified envelope protein 2A

1

1

High-throughput

0.523

High

733172

KR261
Keratin-associated protein 26-1

1

1

High-throughput

0.523

High

733203

KRA94
Keratin-associated protein 9-4

1

20

High-throughput

0.523

High

733221

CHRD
Chordin

1

8

High-throughput

0.523

High

733127

TADBP
TAR DNA-binding protein 43

1

3

High-throughput

0.515

High

733235

DNM3A
DNA

1

1

High-throughput

0.515

High

733220

DPY30
Protein dpy-30 homolog

1

1

High-throughput

0.508

High

586233

ZEP1
Zinc finger protein 40

1

11

High-throughput

0.481

High

733136

PRIC4
Prickle-like protein 4

1

13

High-throughput

0.481

High

733185

ZNF34
Zinc finger protein 34

1

5

High-throughput

0.481

High

733118

H4
Histone H4

1

2

High-throughput

0.479

High

733119

RNF4
E3 ubiquitin-protein ligase RNF4

1

6

High-throughput

0.479

High

733123

EWS
RNA-binding protein EWS

1

7

High-throughput

0.479

High

733197

CIC
Protein capicua homolog

1

20

High-throughput

0.479

High

733231

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

516973

NT2NC
Notch homolog 2 N-terminal-like protein C

1

3

High-throughput

0.470

High

733120

KRT83
Keratin, type II cuticular Hb3

1

5

High-throughput

0.470

High

733126

FBLN3
EGF-containing fibulin-like extracellular matrix protein 1

1

5

High-throughput

0.470

High

733141

KRA63
Keratin-associated protein 6-3

1

1

High-throughput

0.470

High

733143

KR151
Keratin-associated protein 15-1

1

6

High-throughput

0.470

High

733189

OIT3
Oncoprotein-induced transcript 3 protein

1

6

High-throughput

0.470

High

733190

JPH3
Junctophilin-3

1

2

High-throughput

0.470

High

733208

KRA47
Keratin-associated protein 4-7

1

20

High-throughput

0.470

High

733215

KRA24
Keratin-associated protein 2-4

1

20

High-throughput

0.470

High

733228

NTRI
Neurotrimin

1

1

High-throughput

0.470

High

505304

KRA23
Keratin-associated protein 2-3

1

20

High-throughput

0.439

High

733111

KR103
Keratin-associated protein 10-3

1

20

High-throughput

0.439

High

733117

YPEL3
Protein yippee-like 3

1

1

High-throughput

0.439

High

733147

MGT5B
Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B

1

1

High-throughput

0.439

High

733177

NT2NA
Notch homolog 2 N-terminal-like protein A

1

3

High-throughput

0.439

High

733178

R144B
E3 ubiquitin-protein ligase RNF144B

1

3

High-throughput

0.439

High

733180

KR131
Keratin-associated protein 13-1

1

6

High-throughput

0.439

High

733218

TRI31
E3 ubiquitin-protein ligase TRIM31

1

4

High-throughput

0.437

High

733109

KR124
Keratin-associated protein 12-4

3

0

High-throughput

0.352

High

733169

KRA56
Keratin-associated protein 5-6

3

0

High-throughput

0.352

High

733233

CHIC2
Cysteine-rich hydrophobic domain-containing protein 2

3

0

High-throughput

0.348

High

159038

LCE2B
Late cornified envelope protein 2B

2

0

High-throughput

0.316

High

165168

TSN4
Tetraspanin-4

2

0

High-throughput

0.316

High

209879

ADA12
Disintegrin and metalloproteinase domain-containing protein 12

2

0

High-throughput

0.316

High

289345

CTAG2
Cancer/testis antigen 2

2

0

High-throughput

0.316

High

352805

CH25H
Cholesterol 25-hydroxylase

2

0

High-throughput

0.316

High

426054

PPB1
Alkaline phosphatase, placental type

2

0

High-throughput

0.316

High

733132

ETFD
Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial

2

0

High-throughput

0.316

High

733138

KR192
Keratin-associated protein 19-2

2

0

High-throughput

0.316

High

733150

PKHG4
Puratrophin-1

2

0

High-throughput

0.316

High

733151

MIIP
Migration and invasion-inhibitory protein

2

0

High-throughput

0.316

High

733153

GT253
Inactive glycosyltransferase 25 family member 3

2

0

High-throughput

0.316

High

733155

KPRP
Keratinocyte proline-rich protein

2

0

High-throughput

0.316

High

733157

LCE1F
Late cornified envelope protein 1F

2

0

High-throughput

0.316

High

733165

SPRY7
SPRY domain-containing protein 7

2

0

High-throughput

0.316

High

733167

ATG9B
Autophagy-related protein 9B

2

0

High-throughput

0.316

High

733176

UBP54
Ubiquitin carboxyl-terminal hydrolase 54

2

0

High-throughput

0.316

High

733179

FA72B
Protein FAM72B

2

0

High-throughput

0.316

High

733181

KR111
Keratin-associated protein 11-1

2

0

High-throughput

0.316

High

733188

OXER1
Oxoeicosanoid receptor 1

2

0

High-throughput

0.316

High

733196

ARHGH
Rho guanine nucleotide exchange factor 17

2

0

High-throughput

0.316

High

733201

KR171
Keratin-associated protein 17-1

2

0

High-throughput

0.316

High

733217

RTN4R
Reticulon-4 receptor

2

0

High-throughput

0.316

High

733226

PRR13
Proline-rich protein 13

2

0

High-throughput

0.316

High

733160

LCE4A
Late cornified envelope protein 4A

1

0

High-throughput

0.299

High

733198

KCNKG
Potassium channel subfamily K member 16

1

0

High-throughput

0.299

High

622124

NDUV2
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

1

0

High-throughput

0.268

Low

662772

CPT2
Carnitine O-palmitoyltransferase 2, mitochondrial

1

0

High-throughput

0.268

Low

733102

MTR1B
Melatonin receptor type 1B

1

0

High-throughput

0.265

Low

488

NBPFJ
NBPF family member NBPF19

1

0

High-throughput

0.251

Low

243850

GRIN2
G protein-regulated inducer of neurite outgrowth 2

1

0

High-throughput

0.251

Low

733142

KR196
Keratin-associated protein 19-6

1

0

High-throughput

0.251

Low

733144

KR221
Keratin-associated protein 22-1

1

0

High-throughput

0.251

Low

733186

PRR22
Proline-rich protein 22

1

0

High-throughput

0.251

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025