HitPredict

Interactor 1: ARRB2 (P32121)
Beta-arrestin-2 (Arrestin beta-2) (Non-visual arrestin-3)
Gene: ARRB2

Interactor 2: ARRB1 (P49407)
Beta-arrestin-1 (Arrestin beta-1) (Non-visual arrestin-2)
Gene: ARRB1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.86 1.00 0.927

The method score is based on:

Property Details
Experiments 17620599, 28514442, 17353931, 33961781, 24069330
Identification Methods affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, cross-linking study
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Arrestin_C~Arrestin_C, Arrestin_C~Arrestin_N, Arrestin_N~Arrestin_N
Common GO terms GO:0001664 - G protein-coupled receptor binding
GO:0001934 - positive regulation of protein phosphorylation
GO:0002031 - G protein-coupled receptor internalization
GO:0002092 - positive regulation of receptor internalization
GO:0005634 - nucleus
and 15 others

more...
Homologous interactions 12

Homologous interactions

Color coding for hit scores

1 409
Hs

1 418
+ Mm
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+ Hs
+ Rn
+ Hs
+ Hs
+ Hs
+ Hs
+ Bt
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+ Mm
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024