Interactor 1: P5CR1 (P32322)
Pyrroline-5-carboxylate reductase 1, mitochondrial (P5C reductase 1) (P5CR 1) (EC 1.5.1.2)
Gene: PYCR1

Interactor 2: P5CR3 (Q53H96)
Pyrroline-5-carboxylate reductase 3 (P5C reductase 3) (P5CR 3) (EC 1.5.1.2) (Pyrroline-5-carboxylate reductase-like protein)
Gene: PYCR3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.74 1.00 0.861

The method score is based on:

Property Details
Experiments 26186194, 28514442, 33961781
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains F420_oxidored~F420_oxidored, F420_oxidored~P5CR_dimer, P5CR_dimer~P5CR_dimer
Common GO terms GO:0004735 - pyrroline-5-carboxylate reductase activity
GO:0055129 - L-proline biosynthetic process
Homologous interactions 14

Homologous interactions

Color coding for hit scores

1 319
Hs

1 274
+ Hs
+ Hs
+ Hs
+ Hs
+ Ce
+ Mm
+ Hs
+ Dm
+ Dm
+ Dm
+ Sc
+ Cj
+ Hp
+ Dm

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Last updated: 15 Jul 2024