HitPredict

Interactor 1: RPN12 (P32496)
26S proteasome regulatory subunit RPN12 (Nuclear integrity protein 1)
Gene: RPN12

Interactor 2: PRS8 (Q01939)
26S proteasome regulatory subunit 8 homolog (Protein CIM3) (Protein SUG1) (Tat-binding protein TBY1)
Gene: RPT6

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	0.60	0.732

Property	Details
Experiments	11805826, 16554755, 31487956, 14759368, 16429126, 37968396
Identification Methods	tandem affinity purification, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000502 - proteasome complex GO:0005634 - nucleus GO:0034515 - proteasome storage granule GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 274 Sc			1 405
+	At
		1352165 PSD8A_ARATH (2-274): 3.08e-93: 277: 28.06		PRS4A_ARATH (11-395): 5.61e-138: 403: 44.16
+	Hs
		819789 PSMD8_HUMAN (16-274): 3.08e-101: 300: 31.27		PRS8_HUMAN (3-405): 1.36e-129: 380: 73.95
+	Hs
		819792 PSMD8_HUMAN (16-274): 3.08e-101: 300: 31.27		PRS10_HUMAN (20-402): 2.79e-124: 366: 43.34
+	Hs
		819788 PSMD8_HUMAN (16-274): 3.08e-101: 300: 31.27		PRS4_HUMAN (2-395): 3.16e-121: 360: 44.92
+	Hs
		798610 PSMD8_HUMAN (16-274): 3.08e-101: 300: 31.27		PRS6B_HUMAN (13-397): 3.38e-118: 351: 41.04
+	Hs
		730212 PSMD8_HUMAN (16-274): 3.08e-101: 300: 31.27		PRS7_HUMAN (60-390): 7.87e-110: 331: 51.05
+	Sc
		691478 RPN12_YEAST (1-274): 3.71e-102: 300: 100.00		PRS4_YEAST (72-395): 3.99e-106: 321: 49.85
+	Sc
		691456 RPN12_YEAST (1-274): 3.71e-102: 300: 100.00		PRS7_YEAST (83-391): 1.16e-104: 318: 51.78