HitPredict

Interactor 1: SEC17 (P32602)
Alpha-soluble NSF attachment protein (SNAP-alpha) (N-ethylmaleimide-sensitive factor attachment protein alpha) (Vesicular-fusion protein SEC17) (alpha-SNAP chaperone)
Gene: SEC17

Interactor 2: YKT6 (P36015)
Synaptobrevin homolog YKT6 (EC 2.3.1.-)
Gene: YKT6

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	1.00	0.919

Property	Details
Experiments	10385523, 12893879, 15701652, 17522384, 21550981
Identification Methods	coimmunoprecipitation, affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	SNAP~Synaptobrevin
Common GO terms	GO:0005829 - cytosol GO:0006886 - intracellular protein transport GO:0031201 - SNARE complex GO:0042144 - vacuole fusion, non-autophagic GO:0048280 - vesicle fusion with Golgi apparatus
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 292 Sc			1 200
+	Hs
		180842 SNAA_HUMAN (12-291): 5.14e-101: 299: 35.00		YKT6_HUMAN (1-200): 1.87e-71: 216: 47.00
+	Dm
		1095592 SNAP_DROME (3-289): 9.54e-100: 295: 32.40		Q9W3M8_DROME (1-198): 8.66e-70: 212: 44.44
+	Hs
		263203 SNAA_HUMAN (12-291): 5.14e-101: 299: 35.00		SC22B_HUMAN (1-198): 5.84e-63: 195: 21.68
+	Hs
		850546 SNAA_HUMAN (12-291): 5.14e-101: 299: 35.00		VAMP7_HUMAN (28-195): 2.86e-58: 184: 22.60
+	Dm
		115802 SNAP_DROME (3-289): 9.54e-100: 295: 32.40		M9PGI6_DROME (3-198): 1.01e-58: 185: 21.61
+	Dm
		1095560 SNAP_DROME (3-289): 9.54e-100: 295: 32.40		Q7JYX5_DROME (28-196): 1.9e-56: 179: 21.35
+	Zm
		31296 A0A1D6PZ82_MAIZE (2-269): 6.86e-90: 272: 29.85		A0A1D6KH00_MAIZE (21-196): 3.47e-60: 200: 14.97
+	Sc
		605825 SEC17_YEAST (1-292): 5.94e-97: 288: 100.00		SEC22_YEAST (1-194): 4.31e-46: 152: 24.00
+	Hs
		180923 SNAG_HUMAN (1-248): 1.09e-67: 214: 21.20		YKT6_HUMAN (1-200): 1.87e-71: 216: 47.00
+	Hs
		263338 SNAG_HUMAN (1-248): 1.09e-67: 214: 21.20		SC22B_HUMAN (1-198): 5.84e-63: 195: 21.68
+	Dm
		1353755 Q9U6R9_DROME (1-262): 1.1e-59: 194: 21.29		Q9W3M8_DROME (1-198): 8.66e-70: 212: 44.44
+	Hs
		850592 SNAG_HUMAN (1-248): 1.09e-67: 214: 21.20		VAMP7_HUMAN (28-195): 2.86e-58: 184: 22.60
+	Dm
		1366632 Q9VH25_DROME (23-262): 3.76e-56: 184: 21.49		Q9W3M8_DROME (1-198): 8.66e-70: 212: 44.44
+	Dm
		115822 Q9U6R9_DROME (1-262): 1.1e-59: 194: 21.29		M9PGI6_DROME (3-198): 1.01e-58: 185: 21.61
+	Dm
		1178116 Q9U6R9_DROME (1-262): 1.1e-59: 194: 21.29		Q7JYX5_DROME (28-196): 1.9e-56: 179: 21.35
+	Dm
		115828 Q9VH25_DROME (23-262): 3.76e-56: 184: 21.49		M9PGI6_DROME (3-198): 1.01e-58: 185: 21.61
+	Dm
		1178122 Q9VH25_DROME (23-262): 3.76e-56: 184: 21.49		Q7JYX5_DROME (28-196): 1.9e-56: 179: 21.35