Protein: DNA2
DNA replication ATP-dependent helicase/nuclease DNA2 [Includes: DNA replication nuclease DNA2 (EC 3.1.-.-); DNA replication ATP-dependent helicase DNA2 (EC 3.6.4.12)]

Gene: DNA2
Organism: Saccharomyces cerevisiae S288C
Interactions: 33
UniProt ID: P38859

Gene Ontology (top 5):
GO:0000014 - single-stranded DNA endodeoxyribonuclease activity
GO:0000400 - four-way junction DNA binding
GO:0000706 - meiotic DNA double-strand break processing
GO:0000723 - telomere maintenance
GO:0000729 - DNA double-strand break processing

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

647766

RFA1
Replication factor A protein 1

11

3

Small-scale

0.757

High

688743

RFA2
Replication factor A protein 2

3

3

Small-scale

0.656

High

806115

LCD1
DNA damage checkpoint protein LCD1

3

0

High-throughput

0.634

High

364520

CDK1
Cyclin-dependent kinase 1

2

3

Small-scale

0.629

High

763279

SGS1
ATP-dependent helicase SGS1

2

13

Small-scale

0.625

High

689756

FEN1
Flap endonuclease 1

2

7

Small-scale

0.621

High

544824

SSB1
Ribosome-associated molecular chaperone SSB1

2

9

High-throughput

0.601

High

805663

YHS2
MIP18 family protein YHR122W

2

2

High-throughput

0.596

High

806114

CTF4
DNA polymerase alpha-binding protein

1

8

Small-scale

0.594

High

745521

MRE11
Double-strand break repair protein MRE11

2

0

Small-scale

0.581

High

688794

RFA3
Replication factor A protein 3

2

0

High-throughput

0.576

High

526660

HSP72
Heat shock protein SSA2

2

7

High-throughput

0.552

High

741554

HSP7F
Heat shock protein homolog SSE1

2

13

High-throughput

0.552

High

560236

TOP3
DNA topoisomerase 3

1

3

Small-scale

0.515

High

660851

PP2A2
Serine/threonine-protein phosphatase PP2A-2 catalytic subunit

1

2

Small-scale

0.501

High

806116

SIZ2
E3 SUMO-protein ligase SIZ2

1

2

Small-scale

0.501

High

733610

PROB
Glutamate 5-kinase

1

0

High-throughput

0.493

High

586456

PCNA
Proliferating cell nuclear antigen

1

0

Small-scale

0.480

High

726040

FUN30
ATP-dependent helicase FUN30

1

4

Small-scale

0.479

High

793417

ATR
Serine/threonine-protein kinase MEC1

1

8

High-throughput

0.479

High

806112

MET18
DNA repair/transcription protein MET18/MMS19

1

1

High-throughput

0.479

High

751737

PRP8
Pre-mRNA-splicing factor 8

1

0

Small-scale

0.460

High

806113

COM1
DNA endonuclease SAE2

1

0

Small-scale

0.460

High

806117

HUG1
MEC1-mediated checkpoint protein HUG1

1

0

Small-scale

0.460

High

392711

HSP82
ATP-dependent molecular chaperone HSP82

1

2

High-throughput

0.445

High

394543

EF1A
Elongation factor 1-alpha

1

5

High-throughput

0.445

High

510472

HSP77
Import motor subunit, mitochondrial

1

2

High-throughput

0.445

High

579357

HSC82
ATP-dependent molecular chaperone HSC82

1

2

High-throughput

0.445

High

675990

MAS5
Mitochondrial protein import protein MAS5

1

6

High-throughput

0.445

High

742843

HSP79
Heat shock protein homolog SSE2

1

13

High-throughput

0.445

High

752241

HSP78
Heat shock protein 78, mitochondrial

1

2

High-throughput

0.445

High

806111

SSB2
Ribosome-associated molecular chaperone SSB2

1

9

High-throughput

0.445

High

736552

RIM1
Single-stranded DNA-binding protein RIM1, mitochondrial

1

0

High-throughput

0.269

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025