HitPredict

Interactor 1: PRS7 (P33299)
26S proteasome regulatory subunit 7 homolog (Protein CIM5) (Tat-binding homolog 3)
Gene: RPT1

Interactor 2: RPN6 (Q12377)
26S proteasome regulatory subunit RPN6 (Proteasome non-ATPase subunit 4)
Gene: RPN6

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	0.60	0.747

Property	Details
Experiments	11805826, 26245374, 16554755, 16429126, 37968396, 22940862, 14759368, 31778111
Identification Methods	tandem affinity purification, affinity chromatography technology, biochemical, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000502 - proteasome complex GO:0006511 - ubiquitin-dependent protein catabolic process GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 467 Sc			1 434
+	Dm
		1180716 Q9V405_DROME (60-459): 2.26e-135: 397: 35.50		PSD11_DROME (3-433): 1.12e-99: 306: 44.44
+	Hs
		121699 PRS7_HUMAN (12-467): 2.4e-131: 388: 70.40		PSD11_HUMAN (1-433): 4.6e-98: 301: 41.01
+	Dm
		1180706 Q7KMQ0_DROME (12-467): 4.56e-129: 382: 68.64		PSD11_DROME (3-433): 1.12e-99: 306: 44.44
+	At
		1338955 PS6AA_ARATH (12-463): 7.87e-134: 394: 36.28		PSD11_ARATH (31-433): 3.01e-93: 289: 42.65
+	Dm
		1180728 Q9W414_DROME (79-463): 7.34e-124: 367: 43.90		PSD11_DROME (3-433): 1.12e-99: 306: 44.44
+	Dm
		186117 PRS8_DROME (71-464): 6.18e-122: 363: 44.16		PSD11_DROME (3-433): 1.12e-99: 306: 44.44
+	Hs
		121703 PRS6B_HUMAN (43-459): 4.68e-123: 366: 35.49		PSD11_HUMAN (1-433): 4.6e-98: 301: 41.01
+	Hs
		121727 PRS8_HUMAN (81-464): 6.1e-121: 361: 44.53		PSD11_HUMAN (1-433): 4.6e-98: 301: 41.01
+	Sc
		862691 PRS10_YEAST (29-465): 2.46e-123: 367: 37.07		RPN6_YEAST (1-434): 3.45e-95: 294: 100.00
+	Hs
		121729 PRS10_HUMAN (81-463): 5.38e-120: 358: 42.04		PSD11_HUMAN (1-433): 4.6e-98: 301: 41.01
+	Hs
		897226 PRS8_HUMAN (81-464): 6.1e-121: 361: 44.53		CSN2_HUMAN (7-431): 4.9e-93: 289: 19.95
+	Hs
		730263 PRS7_HUMAN (12-467): 2.4e-131: 388: 70.40		PSMD6_HUMAN (65-432): 1.66e-73: 237: 13.78
+	Dm
		1358526 Q9V405_DROME (60-459): 2.26e-135: 397: 35.50		PSMD6_DROME (53-432): 3.17e-69: 226: 13.35
+	Sc
		968100 PRS8_YEAST (142-452): 2.32e-105: 320: 51.77		RPN6_YEAST (1-434): 3.45e-95: 294: 100.00
+	Hs
		798666 PRS6B_HUMAN (43-459): 4.68e-123: 366: 35.49		PSMD6_HUMAN (65-432): 1.66e-73: 237: 13.78
+	Hs
		907033 PRS8_HUMAN (81-464): 6.1e-121: 361: 44.53		PSMD6_HUMAN (65-432): 1.66e-73: 237: 13.78
+	Hs
		913268 PRS10_HUMAN (81-463): 5.38e-120: 358: 42.04		PSMD6_HUMAN (65-432): 1.66e-73: 237: 13.78
+	Dm
		1358538 Q9W414_DROME (79-463): 7.34e-124: 367: 43.90		PSMD6_DROME (53-432): 3.17e-69: 226: 13.35
+	Dm
		186130 PRS8_DROME (71-464): 6.18e-122: 363: 44.16		PSMD6_DROME (53-432): 3.17e-69: 226: 13.35
+	Hs
		874944 TERA_HUMAN (33-442): 6.46e-80: 265: 28.13		PSMD6_HUMAN (65-432): 1.66e-73: 237: 13.78