Protein: MTMR4
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4 (EC 3.1.3.95) (FYVE domain-containing dual specificity protein phosphatase 2) (FYVE-DSP2) (Myotubularin-related protein 4) (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (Zinc finger FYVE domain-containing protein 11)

Gene: MTMR4
Organism: Homo sapiens
Interactions: 162
UniProt ID: Q9NYA4

Gene Ontology (top 5):
GO:0004438 - phosphatidylinositol-3-phosphate phosphatase activity
GO:0004722 - protein serine/threonine phosphatase activity
GO:0004725 - protein tyrosine phosphatase activity
GO:0005615 - extracellular space
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1112460

MTMR3
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3

5

18

Small-scale

0.919

High

1452426

MTMR4
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4

2

17

High-throughput

0.754

High

730290

1433B
14-3-3 protein beta/alpha

7

20

High-throughput

0.741

High

1198539

CEP55
Centrosomal protein of 55 kDa

5

1

High-throughput

0.714

High

966940

1433G
14-3-3 protein gamma

5

20

High-throughput

0.712

High

1049834

1433F
14-3-3 protein eta

5

20

High-throughput

0.706

High

691479

1433T
14-3-3 protein theta

5

20

High-throughput

0.703

High

170385

AURKA
Aurora kinase A

4

6

High-throughput

0.694

High

1312074

DJC10
DnaJ homolog subfamily C member 10

4

4

High-throughput

0.694

High

1351994

RBCC1
RB1-inducible coiled-coil protein 1

3

13

High-throughput

0.656

High

920311

PLK1
Serine/threonine-protein kinase PLK1

3

7

High-throughput

0.640

High

990793

1433Z
14-3-3 protein zeta/delta

3

20

High-throughput

0.640

High

171934

ZN263
Zinc finger protein 263

2

2

High-throughput

0.628

High

488265

LOX5
Polyunsaturated fatty acid 5-lipoxygenase

2

1

High-throughput

0.628

High

1291593

HOOK3
Protein Hook homolog 3

2

14

High-throughput

0.628

High

1350270

RHPN1
Rhophilin-1

2

8

High-throughput

0.628

High

1452436

MTMR7
Phosphatidylinositol-3-phosphate phosphatase MTMR7

1

17

High-throughput

0.618

High

885906

KC1E
Casein kinase I isoform epsilon

2

4

High-throughput

0.611

High

1164330

CDO1
Cysteine dioxygenase type 1

2

0

High-throughput

0.602

High

1385021

ZN669
Zinc finger protein 669

2

0

High-throughput

0.602

High

1392942

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

0

High-throughput

0.602

High

1394351

ZN414
Zinc finger protein 414

2

0

High-throughput

0.602

High

1397715

ZSC31
Zinc finger and SCAN domain-containing protein 31

2

0

High-throughput

0.602

High

1437004

ZN408
Zinc finger protein 408

2

0

High-throughput

0.602

High

1153936

SMAD2
Mothers against decapentaplegic homolog 2

2

9

Small-scale

0.601

High

1212976

ZN684
Zinc finger protein 684

2

0

High-throughput

0.585

High

972059

1433E
14-3-3 protein epsilon

2

7

High-throughput

0.584

High

1386720

AP2M1
AP-2 complex subunit mu

2

3

High-throughput

0.584

High

1414149

MED18
Mediator of RNA polymerase II transcription subunit 18

2

1

High-throughput

0.574

High

861809

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

5

Small-scale

0.561

High

1257832

ACD11
Acyl-CoA dehydrogenase family member 11

2

0

High-throughput

0.559

High

1355968

NET5
Netrin-5

2

1

High-throughput

0.549

High

269400

HSF2B
Heat shock factor 2-binding protein

1

1

High-throughput

0.536

High

335514

SLU7
Pre-mRNA-splicing factor SLU7

1

1

High-throughput

0.536

High

517829

GLI4
Zinc finger protein GLI4

1

1

High-throughput

0.536

High

647320

IL10
Interleukin-10

1

1

High-throughput

0.536

High

682632

S100P
Protein S100-P

1

7

High-throughput

0.536

High

987486

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

2

High-throughput

0.536

High

1323274

SIX5
Homeobox protein SIX5

1

1

High-throughput

0.536

High

1360626

MADD
MAP kinase-activating death domain protein

1

9

High-throughput

0.536

High

1398188

DIESL
DGAT1/2-independent enzyme synthesizing storage lipids

1

1

High-throughput

0.536

High

1413320

DIDO1
Death-inducer obliterator 1

1

3

High-throughput

0.536

High

1415975

IFT27
Intraflagellar transport protein 27 homolog

1

15

High-throughput

0.536

High

1450068

ABCF3
ATP-binding cassette sub-family F member 3

1

1

High-throughput

0.536

High

1451553

ASB6
Ankyrin repeat and SOCS box protein 6

1

4

High-throughput

0.536

High

1452428

GTSE1
G2 and S phase-expressed protein 1

1

1

High-throughput

0.536

High

1452435

PPIE
Peptidyl-prolyl cis-trans isomerase E

1

1

High-throughput

0.536

High

1014639

SMAD3
Mothers against decapentaplegic homolog 3

1

9

Small-scale

0.515

High

49578

FEZF1
Fez family zinc finger protein 1

1

0

High-throughput

0.513

High

226379

SNG1
Synaptogyrin-1

1

0

High-throughput

0.513

High

227001

ENSA
Alpha-endosulfine

1

0

High-throughput

0.513

High

522142

BCL2
Apoptosis regulator Bcl-2

1

0

High-throughput

0.513

High

947897

T2R31
Taste receptor type 2 member 31

1

0

High-throughput

0.513

High

1154461

STK11
Serine/threonine-protein kinase STK11

1

0

High-throughput

0.513

High

1243406

TM154
Transmembrane protein 154

1

0

High-throughput

0.513

High

1244687

IN80C
INO80 complex subunit C

1

0

High-throughput

0.513

High

1387981

RM38
Large ribosomal subunit protein mL38

1

0

High-throughput

0.513

High

1399325

BIRC8
Baculoviral IAP repeat-containing protein 8

1

0

High-throughput

0.513

High

1400469

TRNT1
CCA tRNA nucleotidyltransferase 1, mitochondrial

1

0

High-throughput

0.513

High

1452432

SALL4
Sal-like protein 4

1

0

High-throughput

0.513

High

1452433

CAPS1
Calcium-dependent secretion activator 1

1

0

High-throughput

0.513

High

1452434

PADI4
Protein-arginine deiminase type-4

1

0

High-throughput

0.513

High

1433057

HIPK3
Homeodomain-interacting protein kinase 3

1

5

High-throughput

0.508

High

1396993

VATG3
V-type proton ATPase subunit G 3

1

0

High-throughput

0.493

High

706337

S10A2
Protein S100-A2

1

7

High-throughput

0.489

High

1314260

SPB1
pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3

1

2

High-throughput

0.489

High

1370927

FOXJ1
Forkhead box protein J1

1

2

High-throughput

0.489

High

157926

CTRO
Citron Rho-interacting kinase

1

6

High-throughput

0.479

High

230123

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

1

2

High-throughput

0.479

High

272506

OBSL1
Obscurin-like protein 1

1

4

High-throughput

0.479

High

323793

AP2A2
AP-2 complex subunit alpha-2

1

5

High-throughput

0.479

High

327478

ZFPL1
Zinc finger protein-like 1

1

1

High-throughput

0.479

High

334113

SMC2
Structural maintenance of chromosomes protein 2

1

3

High-throughput

0.479

High

344812

AP2A1
AP-2 complex subunit alpha-1

1

5

High-throughput

0.479

High

687877

SYVC
Valine--tRNA ligase

1

4

High-throughput

0.479

High

703075

DPOD1
DNA polymerase delta catalytic subunit

1

1

High-throughput

0.479

High

714658

TYK2
Non-receptor tyrosine-protein kinase TYK2

1

10

High-throughput

0.479

High

720808

PUR8
Adenylosuccinate lyase

1

2

High-throughput

0.479

High

730918

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

835768

KPCI
Protein kinase C iota type

1

4

High-throughput

0.479

High

877020

KC1A
Casein kinase I isoform alpha

1

4

High-throughput

0.479

High

877249

KC1D
Casein kinase I isoform delta

1

4

High-throughput

0.479

High

913414

MSH6
DNA mismatch repair protein Msh6

1

1

High-throughput

0.479

High

954628

PRPS1
Ribose-phosphate pyrophosphokinase 1

1

1

High-throughput

0.479

High

956020

RAB8A
Ras-related protein Rab-8A

1

6

High-throughput

0.479

High

976610

RB11A
Ras-related protein Rab-11A

1

8

High-throughput

0.479

High

989139

AP2B1
AP-2 complex subunit beta

1

6

High-throughput

0.479

High

1010385

BASP1
Brain acid soluble protein 1

1

2

High-throughput

0.479

High

1017499

FOXK1
Forkhead box protein K1

1

2

High-throughput

0.479

High

1060498

DPOE1
DNA polymerase epsilon catalytic subunit A

1

1

High-throughput

0.479

High

1083325

AP1B1
AP-1 complex subunit beta-1

1

5

High-throughput

0.479

High

1100461

TIF1B
Transcription intermediary factor 1-beta

1

7

High-throughput

0.479

High

1108217

SQSTM
Sequestosome-1

1

5

High-throughput

0.479

High

1113004

CUL2
Cullin-2

1

10

High-throughput

0.479

High

1114468

CUL3
Cullin-3

1

10

High-throughput

0.479

High

1121351

TRI14
Tripartite motif-containing protein 14

1

6

High-throughput

0.479

High

1163906

DUS7
Dual specificity protein phosphatase 7

1

2

High-throughput

0.479

High

1178643

KIF7
Kinesin-like protein KIF7

1

4

High-throughput

0.479

High

1241128

C2D1A
Coiled-coil and C2 domain-containing protein 1A

1

4

High-throughput

0.479

High

1288590

ZN598
E3 ubiquitin-protein ligase ZNF598

1

2

High-throughput

0.479

High

1330303

KC1AL
Casein kinase I isoform alpha-like

1

7

High-throughput

0.479

High

1337506

ZN548
Zinc finger protein 548

1

1

High-throughput

0.479

High

1340681

NEDD1
Protein NEDD1

1

4

High-throughput

0.479

High

1348346

GOGA5
Golgin subfamily A member 5

1

13

High-throughput

0.479

High

1382595

EXOC4
Exocyst complex component 4

1

1

High-throughput

0.479

High

1386610

OPTN
Optineurin

1

14

High-throughput

0.479

High

1399108

SCLT1
Sodium channel and clathrin linker 1

1

12

High-throughput

0.479

High

1407172

PI51A
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha

1

4

High-throughput

0.479

High

1428391

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

14

High-throughput

0.479

High

1437275

ELP3
Elongator complex protein 3

1

1

High-throughput

0.479

High

1445736

WDR6
tRNA

1

9

High-throughput

0.479

High

1449548

SMC4
Structural maintenance of chromosomes protein 4

1

5

High-throughput

0.479

High

1452430

VAPA
Vesicle-associated membrane protein-associated protein A

1

2

High-throughput

0.479

High

1452438

PKP3
Plakophilin-3

1

4

High-throughput

0.479

High

1452439

IRS2
Insulin receptor substrate 2

1

4

High-throughput

0.479

High

1452440

SNX8
Sorting nexin-8

1

14

High-throughput

0.479

High

1412158

ERP44
Endoplasmic reticulum resident protein 44

1

5

High-throughput

0.470

High

163177

CHK1
Serine/threonine-protein kinase Chk1

1

0

High-throughput

0.458

High

284478

HSBP1
Heat shock factor-binding protein 1

1

0

High-throughput

0.458

High

451641

GPX1
Glutathione peroxidase 1

1

0

High-throughput

0.458

High

703726

MK01
Mitogen-activated protein kinase 1

1

0

High-throughput

0.458

High

756072

MCM5
DNA replication licensing factor MCM5

1

0

High-throughput

0.458

High

841267

CNDD3
Condensin-2 complex subunit D3

1

0

High-throughput

0.458

High

1095314

REST
RE1-silencing transcription factor

1

0

High-throughput

0.458

High

1107629

PICAL
Phosphatidylinositol-binding clathrin assembly protein

1

0

High-throughput

0.458

High

1163946

UPP1
Uridine phosphorylase 1

1

0

High-throughput

0.458

High

1233805

CNDH2
Condensin-2 complex subunit H2

1

0

High-throughput

0.458

High

1293751

CNDG2
Condensin-2 complex subunit G2

1

0

High-throughput

0.458

High

1356409

PPIL4
Peptidyl-prolyl cis-trans isomerase-like 4

1

0

High-throughput

0.458

High

1363996

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

0

High-throughput

0.458

High

1393514

PGAM5
Serine/threonine-protein phosphatase PGAM5, mitochondrial

1

0

High-throughput

0.458

High

1437447

KT3K
Ketosamine-3-kinase

1

0

High-throughput

0.458

High

1449201

LANC2
LanC-like protein 2

1

0

High-throughput

0.458

High

1452431

DIP2B
Disco-interacting protein 2 homolog B

1

0

High-throughput

0.458

High

1057003

FMR1
Fragile X messenger ribonucleoprotein 1

1

4

High-throughput

0.457

High

401597

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

2

High-throughput

0.445

High

1433644

E41L1
Band 4.1-like protein 1

1

3

High-throughput

0.445

High

228867

SCO2
Protein SCO2 homolog, mitochondrial

1

4

High-throughput

0.437

High

1029770

FOXK2
Forkhead box protein K2

1

2

High-throughput

0.437

High

1109523

ATR
Serine/threonine-protein kinase ATR

1

6

High-throughput

0.437

High

1311878

DHX40
Probable ATP-dependent RNA helicase DHX40

1

3

High-throughput

0.437

High

1450579

ATD3A
ATPase family AAA domain-containing protein 3A

1

7

High-throughput

0.437

High

1212980

Q5T5D8
Zinc finger protein 684

1

2

High-throughput

0.407

High

1258593

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

2

High-throughput

0.407

High

1335753

MOT11
Monocarboxylate transporter 11

1

3

High-throughput

0.407

High

155623

NEMP1
Nuclear envelope integral membrane protein 1

1

0

High-throughput

0.279

Low

192513

INSI1
Insulin-induced gene 1 protein

1

0

High-throughput

0.279

Low

260735

RAMP1
Receptor activity-modifying protein 1

1

0

High-throughput

0.279

Low

281256

CDC45
Cell division control protein 45 homolog

1

0

High-throughput

0.279

Low

1126377

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

1

0

High-throughput

0.279

Low

1308377

CCD71
Coiled-coil domain-containing protein 71

1

0

High-throughput

0.279

Low

1452429

COQ3
Ubiquinone biosynthesis O-methyltransferase, mitochondrial

1

0

High-throughput

0.279

Low

168905

PLD2
Phospholipase D2

1

0

High-throughput

0.249

Low

829281

RFC3
Replication factor C subunit 3

1

0

High-throughput

0.249

Low

940507

DPOE2
DNA polymerase epsilon subunit 2

1

0

High-throughput

0.249

Low

1294777

PTH
Peptidyl-tRNA hydrolase

1

0

High-throughput

0.249

Low

1322510

PUSL1
tRNA pseudouridine synthase-like 1

1

0

High-throughput

0.249

Low

1381753

FAKD4
FAST kinase domain-containing protein 4

1

0

High-throughput

0.249

Low

1451595

TM160
Transmembrane protein 160

1

0

High-throughput

0.249

Low

1452427

UTP6
U3 small nucleolar RNA-associated protein 6 homolog

1

0

High-throughput

0.249

Low

1452437

PDIP2
Polymerase delta-interacting protein 2

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025