Protein: ULK1
Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Autophagy-related protein 1 homolog) (ATG1) (hATG1) (Unc-51-like kinase 1)

Gene: ULK1
Organism: Homo sapiens
Interactions: 145
UniProt ID: O75385

Gene Ontology (top 5):
GO:0000045 - autophagosome assembly
GO:0000407 - phagophore assembly site
GO:0000421 - autophagosome membrane
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

262266

SQSTM
Sequestosome-1

6

10

Small-scale

0.950

High

262261

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

4

19

Small-scale

0.908

High

262288

RPTOR
Regulatory-associated protein of mTOR

4

12

Small-scale

0.902

High

262203

ULK1
Serine/threonine-protein kinase ULK1

3

20

Small-scale

0.866

High

262244

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

3

18

Small-scale

0.847

High

262331

AAKB1
5'-AMP-activated protein kinase subunit beta-1

2

18

Small-scale

0.802

High

262278

CDC37
Hsp90 co-chaperone Cdc37

2

10

Small-scale

0.789

High

255007

ATG13
Autophagy-related protein 13

27

5

Small-scale

0.769

High

262292

RBCC1
RB1-inducible coiled-coil protein 1

17

20

Small-scale

0.764

High

262310

ATGA1
Autophagy-related protein 101

9

4

Small-scale

0.755

High

262270

BECN1
Beclin-1

10

3

Small-scale

0.755

High

262219

HS90A
Heat shock protein HSP 90-alpha

2

20

Small-scale

0.754

High

262253

RAB1A
Ras-related protein Rab-1A

2

4

Small-scale

0.754

High

262305

NLRP3
NACHT, LRR and PYD domains-containing protein 3

2

2

Small-scale

0.754

High

262277

MK14
Mitogen-activated protein kinase 14

1

10

Small-scale

0.747

High

262209

GBRAP
Gamma-aminobutyric acid receptor-associated protein

6

12

Small-scale

0.734

High

262239

MTOR
Serine/threonine-protein kinase mTOR

6

12

Small-scale

0.733

High

262227

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

16

Small-scale

0.724

High

262328

ST38L
Serine/threonine-protein kinase 38-like

1

18

Small-scale

0.724

High

262316

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

5

12

Small-scale

0.716

High

262249

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

4

12

Small-scale

0.708

High

262283

BAKOR
Beclin 1-associated autophagy-related key regulator

4

1

Small-scale

0.705

High

262314

MLP3C
Microtubule-associated proteins 1A/1B light chain 3C

4

12

Small-scale

0.696

High

262307

NED4L
E3 ubiquitin-protein ligase NEDD4-like

4

16

Small-scale

0.692

High

262264

G3BP1
Ras GTPase-activating protein-binding protein 1

1

3

High-throughput

0.691

High

262299

SGK3
Serine/threonine-protein kinase Sgk3

1

18

High-throughput

0.691

High

262306

RBM14
RNA-binding protein 14

1

1

High-throughput

0.691

High

262319

MLP3A
Microtubule-associated proteins 1A/1B light chain 3A

4

12

Small-scale

0.689

High

262304

CI072
Guanine nucleotide exchange factor C9orf72

5

0

Small-scale

0.676

High

262315

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

3

5

Small-scale

0.667

High

262243

AAKG1
5'-AMP-activated protein kinase subunit gamma-1

3

18

Small-scale

0.667

High

262332

TRAF6
TNF receptor-associated factor 6

3

15

Small-scale

0.662

High

262317

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

3

12

Small-scale

0.658

High

262280

A16L1
Autophagy-related protein 16-1

3

13

Small-scale

0.656

High

201730

RIPK2
Receptor-interacting serine/threonine-protein kinase 2

1

4

Small-scale

0.647

High

262216

NTRK1
High affinity nerve growth factor receptor

1

17

Small-scale

0.646

High

262236

FGFR4
Fibroblast growth factor receptor 4

1

14

High-throughput

0.646

High

262247

SESN2
Sestrin-2

2

1

Small-scale

0.639

High

262285

ATG9A
Autophagy-related protein 9A

2

2

Small-scale

0.634

High

241248

HNRC1
Heterogeneous nuclear ribonucleoprotein C-like 1

1

5

High-throughput

0.618

High

182060

PDPK1
3-phosphoinositide-dependent protein kinase 1

1

19

Small-scale

0.618

High

200078

DAPK3
Death-associated protein kinase 3

1

19

Small-scale

0.618

High

212331

AAKB2
5'-AMP-activated protein kinase subunit beta-2

1

19

High-throughput

0.618

High

262221

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.618

High

262229

RALB
Ras-related protein Ral-B

1

14

Small-scale

0.618

High

262248

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

2

Small-scale

0.618

High

262275

KIF14
Kinesin-like protein KIF14

1

9

High-throughput

0.618

High

262313

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

20

Small-scale

0.618

High

262326

TBK1
Serine/threonine-protein kinase TBK1

1

19

Small-scale

0.618

High

262237

MAP4
Microtubule-associated protein 4

2

20

Small-scale

0.611

High

262250

1433G
14-3-3 protein gamma

2

20

High-throughput

0.601

High

262290

FLCN
Folliculin

2

0

Small-scale

0.598

High

262262

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

2

14

Small-scale

0.595

High

262301

NRBF2
Nuclear receptor-binding factor 2

2

0

Small-scale

0.592

High

262271

NBR1
Next to BRCA1 gene 1 protein

1

0

High-throughput

0.586

High

262235

RO52
E3 ubiquitin-protein ligase TRIM21

2

5

Small-scale

0.584

High

262241

NEDD4
E3 ubiquitin-protein ligase NEDD4

2

16

Small-scale

0.584

High

262230

TRI27
Zinc finger protein RFP

1

5

Small-scale

0.578

High

262298

MUL1
Mitochondrial ubiquitin ligase activator of NFKB 1

1

9

Small-scale

0.578

High

262329

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

1

16

Small-scale

0.578

High

262215

MBP
Myelin basic protein

2

0

Small-scale

0.577

High

262308

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

15

Small-scale

0.573

High

262293

SMCR8
Guanine nucleotide exchange protein SMCR8

2

0

Small-scale

0.561

High

183318

MEFV
Pyrin

1

4

Small-scale

0.561

High

262211

TRI16
Tripartite motif-containing protein 16

1

5

Small-scale

0.561

High

262212

STABP
STAM-binding protein

1

1

Small-scale

0.561

High

262240

HD
Huntingtin

1

8

Small-scale

0.554

High

132683

SDCB1
Syntenin-1

1

8

Small-scale

0.552

High

61161

PDES1
Plasmanylethanolamine desaturase 1

1

0

Small-scale

0.537

High

262257

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

Small-scale

0.537

High

262287

EXOC8
Exocyst complex component 8

1

0

Small-scale

0.537

High

262210

RCBT2
RCC1 and BTB domain-containing protein 2

1

4

High-throughput

0.536

High

262214

CYTS
Cystatin-S

1

2

High-throughput

0.536

High

262220

TPM2
Tropomyosin beta chain

1

9

High-throughput

0.536

High

262222

CATG
Cathepsin G

1

3

High-throughput

0.536

High

262224

TPM1
Tropomyosin alpha-1 chain

1

10

High-throughput

0.536

High

262225

CLCB
Clathrin light chain B

1

2

High-throughput

0.536

High

262238

MARCS
Myristoylated alanine-rich C-kinase substrate

1

3

High-throughput

0.536

High

262252

1433E
14-3-3 protein epsilon

1

20

High-throughput

0.536

High

262254

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.536

High

262258

AKP13
A-kinase anchor protein 13

1

12

High-throughput

0.536

High

262273

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

8

High-throughput

0.536

High

262286

RB6I2
ELKS/Rab6-interacting/CAST family member 1

1

13

High-throughput

0.536

High

262318

ATG5
Autophagy protein 5

1

2

Small-scale

0.536

High

262333

ATG4B
Cysteine protease ATG4B

1

1

High-throughput

0.536

High

262204

HSBP1
Heat shock factor-binding protein 1

1

0

High-throughput

0.513

High

262242

GLYG
Glycogenin-1

1

0

High-throughput

0.513

High

262294

BRK1
Protein BRICK1

1

0

High-throughput

0.513

High

262327

JUPI1
Jupiter microtubule associated homolog 1

1

0

High-throughput

0.513

High

262251

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

20

Small-scale

0.508

High

262323

TBC14
TBC1 domain family member 14

1

3

Small-scale

0.506

High

164719

SC16A
Protein transport protein Sec16A

1

3

Small-scale

0.479

High

262206

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

7

Small-scale

0.479

High

262207

ATG12
Ubiquitin-like protein ATG12

1

1

Small-scale

0.479

High

262208

UBP19
Ubiquitin carboxyl-terminal hydrolase 19

1

12

Small-scale

0.479

High

262213

LDHA
L-lactate dehydrogenase A chain

1

2

Small-scale

0.479

High

262217

P53
Cellular tumor antigen p53

1

3

High-throughput

0.479

High

262218

NPM
Nucleophosmin

1

1

Small-scale

0.479

High

262223

VIME
Vimentin

1

6

Small-scale

0.479

High

262226

PARP1
Poly [ADP-ribose] polymerase 1

1

5

Small-scale

0.479

High

262231

KPYM
Pyruvate kinase PKM

1

2

Small-scale

0.479

High

262233

CXA1
Gap junction alpha-1 protein

1

7

Small-scale

0.479

High

262255

E2F1
Transcription factor E2F1

1

1

Small-scale

0.479

High

262259

TRI32
E3 ubiquitin-protein ligase TRIM32

1

6

Small-scale

0.479

High

262260

TRAF3
TNF receptor-associated factor 3

1

14

Small-scale

0.479

High

262265

BIRC2
Baculoviral IAP repeat-containing protein 2

1

9

Small-scale

0.479

High

262268

KEAP1
Kelch-like ECH-associated protein 1

1

2

Small-scale

0.479

High

262269

GAS6
Growth arrest-specific protein 6

1

2

High-throughput

0.479

High

262272

IRF3
Interferon regulatory factor 3

1

2

Small-scale

0.479

High

262276

E2F4
Transcription factor E2F4

1

1

Small-scale

0.479

High

262281

OTU7B
OTU domain-containing protein 7B

1

7

Small-scale

0.479

High

262291

WDR48
WD repeat-containing protein 48

1

8

Small-scale

0.479

High

262296

ESR2
Estrogen receptor beta

1

20

Small-scale

0.479

High

262297

BAD
Bcl2-associated agonist of cell death

1

2

Small-scale

0.479

High

262300

OPTN
Optineurin

1

19

High-throughput

0.479

High

262302

STALP
AMSH-like protease

1

1

Small-scale

0.479

High

262309

FEZ1
Fasciculation and elongation protein zeta-1

1

1

Small-scale

0.479

High

262311

LST8
Target of rapamycin complex subunit LST8

1

5

Small-scale

0.479

High

262321

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

3

Small-scale

0.479

High

262324

HDAC6
Histone deacetylase 6

1

16

Small-scale

0.479

High

262325

AAKG3
5'-AMP-activated protein kinase subunit gamma-3

1

18

High-throughput

0.479

High

262279

OCLN
Occludin

1

2

Small-scale

0.464

High

49651

IRGM
Immunity-related GTPase family M protein

1

0

Small-scale

0.458

High

262228

CLUS
Clusterin

1

0

Small-scale

0.458

High

262256

RAD51
DNA repair protein RAD51 homolog 1

1

0

Small-scale

0.458

High

262267

PTC1
Protein patched homolog 1

1

0

Small-scale

0.458

High

262274

JOS1
Josephin-1

1

0

Small-scale

0.458

High

262303

EXOC2
Exocyst complex component 2

1

0

Small-scale

0.458

High

262263

CBLB
E3 ubiquitin-protein ligase CBL-B

1

2

Small-scale

0.445

High

262295

TBCD5
TBC1 domain family member 5

1

2

Small-scale

0.445

High

262320

ZFYV1
Zinc finger FYVE domain-containing protein 1

1

2

Small-scale

0.445

High

262322

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.438

High

262232

H2AX
Histone H2AX

1

4

Small-scale

0.437

High

259396

NIPS2
Protein NipSnap homolog 2

1

0

High-throughput

0.426

High

262330

WASC3
WASH complex subunit 3

2

0

High-throughput

0.328

High

61776

F221B
Protein FAM221B

1

0

High-throughput

0.279

Low

262205

ATP5H
ATP synthase subunit d, mitochondrial

1

0

High-throughput

0.279

Low

262234

ATP5J
ATP synthase-coupling factor 6, mitochondrial

1

0

High-throughput

0.279

Low

262245

ATP5E
ATP synthase subunit epsilon, mitochondrial

1

0

High-throughput

0.279

Low

262246

ATP5I
ATP synthase subunit e, mitochondrial

1

0

High-throughput

0.279

Low

262282

RM14
Large ribosomal subunit protein uL14m

1

0

High-throughput

0.279

Low

262284

PHF5A
PHD finger-like domain-containing protein 5A

1

0

High-throughput

0.279

Low

262289

GOLM1
Golgi membrane protein 1

1

0

High-throughput

0.279

Low

262312

B2L13
Bcl-2-like protein 13

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024