Protein: MED12
Mediator of RNA polymerase II transcription subunit 12 (Activator-recruited cofactor 240 kDa component) (ARC240) (CAG repeat protein 45) (Mediator complex subunit 12) (OPA-containing protein) (Thyroid hormone receptor-associated protein complex 230 kDa component) (Trap230) (Trinucleotide repeat-containing gene 11 protein)

Gene: MED12
Organism: Homo sapiens
Interactions: 161
UniProt ID: Q93074

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001843 - neural tube closure
GO:0003682 - chromatin binding
GO:0003712 - transcription coregulator activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

826329

CDK8
Cyclin-dependent kinase 8

21

13

Small-scale

0.765

High

1274341

CDK19
Cyclin-dependent kinase 19

11

12

Small-scale

0.756

High

1076182

MED1
Mediator of RNA polymerase II transcription subunit 1

10

16

Small-scale

0.755

High

1274339

MED10
Mediator of RNA polymerase II transcription subunit 10

10

1

Small-scale

0.755

High

48706

MED19
Mediator of RNA polymerase II transcription subunit 19

9

1

Small-scale

0.754

High

1274340

MED18
Mediator of RNA polymerase II transcription subunit 18

7

1

Small-scale

0.751

High

1274349

MED4
Mediator of RNA polymerase II transcription subunit 4

7

2

Small-scale

0.750

High

1274355

MED29
Mediator of RNA polymerase II transcription subunit 29

7

1

Small-scale

0.749

High

1274347

MED20
Mediator of RNA polymerase II transcription subunit 20

7

1

High-throughput

0.748

High

225404

MED14
Mediator of RNA polymerase II transcription subunit 14

7

18

Small-scale

0.746

High

1274330

MED30
Mediator of RNA polymerase II transcription subunit 30

7

1

Small-scale

0.745

High

1037081

MED21
Mediator of RNA polymerase II transcription subunit 21

6

2

High-throughput

0.738

High

270520

MED6
Mediator of RNA polymerase II transcription subunit 6

6

1

High-throughput

0.733

High

1158908

MED27
Mediator of RNA polymerase II transcription subunit 27

6

1

High-throughput

0.733

High

1274354

MED9
Mediator of RNA polymerase II transcription subunit 9

6

1

Small-scale

0.732

High

1274360

MED13
Mediator of RNA polymerase II transcription subunit 13

6

4

High-throughput

0.732

High

1274344

MED28
Mediator of RNA polymerase II transcription subunit 28

6

1

Small-scale

0.732

High

624480

CCNC
Cyclin-C

6

6

Small-scale

0.727

High

206637

MED7
Mediator of RNA polymerase II transcription subunit 7

5

1

High-throughput

0.722

High

1274370

MED31
Mediator of RNA polymerase II transcription subunit 31

5

2

High-throughput

0.722

High

1274353

MED17
Mediator of RNA polymerase II transcription subunit 17

5

1

High-throughput

0.718

High

1274356

MED11
Mediator of RNA polymerase II transcription subunit 11

5

1

High-throughput

0.718

High

1274328

MED8
Mediator of RNA polymerase II transcription subunit 8

5

1

High-throughput

0.714

High

1274333

MED15
Mediator of RNA polymerase II transcription subunit 15

5

10

Small-scale

0.714

High

1274362

MED23
Mediator of RNA polymerase II transcription subunit 23

5

5

Small-scale

0.712

High

265350

MED24
Mediator of RNA polymerase II transcription subunit 24

4

1

High-throughput

0.694

High

313452

MED26
Mediator of RNA polymerase II transcription subunit 26

4

1

Small-scale

0.694

High

1174762

MD13L
Mediator of RNA polymerase II transcription subunit 13-like

4

4

High-throughput

0.694

High

1174949

MED25
Mediator of RNA polymerase II transcription subunit 25

4

2

Small-scale

0.694

High

1274368

MED16
Mediator of RNA polymerase II transcription subunit 16

4

1

High-throughput

0.694

High

370154

ESR1
Estrogen receptor

4

20

Small-scale

0.689

High

1074715

MED22
Mediator of RNA polymerase II transcription subunit 22

4

2

High-throughput

0.686

High

509969

VDR
Vitamin D3 receptor

3

20

Small-scale

0.664

High

738986

SRBP1
Sterol regulatory element-binding protein 1

3

15

Small-scale

0.641

High

1022961

CDC16
Cell division cycle protein 16 homolog

2

6

High-throughput

0.628

High

1152370

CNDH2
Condensin-2 complex subunit H2

2

1

High-throughput

0.628

High

487651

ANDR
Androgen receptor

2

20

High-throughput

0.612

High

801287

KI67
Proliferation marker protein Ki-67

2

16

High-throughput

0.611

High

1271435

KAT2A
Histone acetyltransferase KAT2A

2

20

Small-scale

0.601

High

1269298

ESR2
Estrogen receptor beta

2

20

Small-scale

0.585

High

244751

BRD4
Bromodomain-containing protein 4

2

16

Small-scale

0.584

High

1274325

FBXW7
F-box/WD repeat-containing protein 7

2

8

Small-scale

0.584

High

1274361

RCOR1
REST corepressor 1

2

13

High-throughput

0.584

High

818833

SOX9
Transcription factor SOX-9

1

20

Small-scale

0.573

High

500440

THA
Thyroid hormone receptor alpha

2

20

Small-scale

0.571

High

1274331

EHMT2
Histone-lysine N-methyltransferase EHMT2

1

6

Small-scale

0.561

High

1274359

PRGC1
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

1

2

Small-scale

0.561

High

583762

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

2

0

High-throughput

0.559

High

1274348

NANOG
Homeobox protein NANOG

1

20

Small-scale

0.552

High

117788

MYO1C
Unconventional myosin-Ic

1

3

High-throughput

0.536

High

122921

MEN1
Menin

1

2

High-throughput

0.536

High

172892

CASC3
Protein CASC3

1

18

High-throughput

0.536

High

1085631

HIF1A
Hypoxia-inducible factor 1-alpha

1

19

Small-scale

0.536

High

1160880

FXL19
F-box/LRR-repeat protein 19

1

4

High-throughput

0.536

High

1236427

SIR6
NAD-dependent protein deacylase sirtuin-6

1

8

High-throughput

0.536

High

1271155

RBP56
TATA-binding protein-associated factor 2N

1

16

High-throughput

0.536

High

831553

CEBPA
CCAAT/enhancer-binding protein alpha

1

20

High-throughput

0.527

High

485140

GLI3
Transcriptional activator GLI3

1

5

Small-scale

0.527

High

740028

TGFR2
TGF-beta receptor type-2

1

1

Small-scale

0.515

High

267677

TADA3
Transcriptional adapter 3

1

0

High-throughput

0.513

High

327687

ECD
Protein ecdysoneless homolog

1

0

High-throughput

0.513

High

890318

SC61B
Protein transport protein Sec61 subunit beta

1

0

High-throughput

0.513

High

1233819

CCD82
Coiled-coil domain-containing protein 82

1

0

High-throughput

0.513

High

395393

A4
Amyloid-beta precursor protein

1

5

Small-scale

0.501

High

849945

APLP1
Amyloid beta precursor like protein 1

1

5

Small-scale

0.501

High

987531

APLP2
Amyloid beta precursor like protein 2

1

5

Small-scale

0.501

High

426704

H10
Histone H1.0

1

0

High-throughput

0.493

High

174121

SPTC1
Serine palmitoyltransferase 1

1

2

High-throughput

0.489

High

474300

OCM2
Putative oncomodulin-2

1

3

High-throughput

0.489

High

1120798

KLH12
Kelch-like protein 12

1

4

High-throughput

0.489

High

1274338

LZTS2
Leucine zipper putative tumor suppressor 2

1

19

High-throughput

0.489

High

1274343

SHRPN
Sharpin

1

2

High-throughput

0.489

High

1274336

LYST
Lysosomal-trafficking regulator

1

6

Small-scale

0.481

High

134153

DDX3X
ATP-dependent RNA helicase DDX3X

1

8

High-throughput

0.479

High

163091

XPO1
Exportin-1

1

3

High-throughput

0.479

High

197791

CRX
Cone-rod homeobox protein

1

20

High-throughput

0.479

High

232397

KDM1A
Lysine-specific histone demethylase 1A

1

8

High-throughput

0.479

High

266402

TAD2A
Transcriptional adapter 2-alpha

1

10

High-throughput

0.479

High

347514

MYC
Myc proto-oncogene protein

1

20

High-throughput

0.479

High

374646

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

16

High-throughput

0.479

High

415433

ATPB
ATP synthase subunit beta, mitochondrial

1

2

High-throughput

0.479

High

504519

HSP7C
Heat shock cognate 71 kDa protein

1

3

High-throughput

0.479

High

561647

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

1

High-throughput

0.479

High

571543

DDX5
Probable ATP-dependent RNA helicase DDX5

1

8

High-throughput

0.479

High

583539

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

2

High-throughput

0.479

High

624983

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

1

High-throughput

0.479

High

637012

ATPA
ATP synthase subunit alpha, mitochondrial

1

2

High-throughput

0.479

High

643563

PTBP1
Polypyrimidine tract-binding protein 1

1

8

High-throughput

0.479

High

676955

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

1

High-throughput

0.479

High

681548

DNJA1
DnaJ homolog subfamily A member 1

1

2

High-throughput

0.479

High

718081

BMI1
Polycomb complex protein BMI-1

1

12

High-throughput

0.479

High

738864

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

1

High-throughput

0.479

High

749747

BRCA1
Breast cancer type 1 susceptibility protein

1

6

High-throughput

0.479

High

779859

CCNF
Cyclin-F

1

5

High-throughput

0.479

High

794066

MATR3
Matrin-3

1

3

High-throughput

0.479

High

808822

YAP1
Transcriptional coactivator YAP1

1

20

High-throughput

0.479

High

822120

KC1A
Casein kinase I isoform alpha

1

3

High-throughput

0.479

High

841840

CDK9
Cyclin-dependent kinase 9

1

6

High-throughput

0.479

High

853020

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

4

High-throughput

0.479

High

854340

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

1

High-throughput

0.479

High

890787

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

1

Small-scale

0.479

High

919200

RAN
GTP-binding nuclear protein Ran

1

1

High-throughput

0.479

High

924102

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

2

High-throughput

0.479

High

941263

RNF4
E3 ubiquitin-protein ligase RNF4

1

3

High-throughput

0.479

High

964387

RUNX1
Runt-related transcription factor 1

1

4

High-throughput

0.479

High

991839

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

3

High-throughput

0.479

High

1019059

TP53B
TP53-binding protein 1

1

14

High-throughput

0.479

High

1038601

HDAC1
Histone deacetylase 1

1

7

High-throughput

0.479

High

1048168

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

8

Small-scale

0.479

High

1053944

CAPR1
Caprin-1

1

7

High-throughput

0.479

High

1056918

MDC1
Mediator of DNA damage checkpoint protein 1

1

20

High-throughput

0.479

High

1061035

NOLC1
Nucleolar and coiled-body phosphoprotein 1

1

5

High-throughput

0.479

High

1061197

NUMA1
Nuclear mitotic apparatus protein 1

1

3

High-throughput

0.479

High

1061329

NR1I3
Nuclear receptor subfamily 1 group I member 3

1

20

High-throughput

0.479

High

1076272

TRIP4
Activating signal cointegrator 1

1

1

High-throughput

0.479

High

1132719

ZC3HD
Zinc finger CCCH domain-containing protein 13

1

5

High-throughput

0.479

High

1154063

NIPBL
Nipped-B-like protein

1

17

High-throughput

0.479

High

1173747

ACD11
Acyl-CoA dehydrogenase family member 11

1

1

High-throughput

0.479

High

1206151

MD12L
Mediator of RNA polymerase II transcription subunit 12-like protein

1

18

High-throughput

0.479

High

1242621

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

15

Small-scale

0.479

High

1243877

FBX22
F-box only protein 22

1

2

High-throughput

0.479

High

1244412

NUP43
Nucleoporin Nup43

1

20

High-throughput

0.479

High

1274326

WBP2
WW domain-binding protein 2

1

2

High-throughput

0.479

High

1274327

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

13

High-throughput

0.479

High

1274332

QKI
KH domain-containing RNA-binding protein QKI

1

3

High-throughput

0.479

High

1274337

EPAS1
Endothelial PAS domain-containing protein 1

1

19

Small-scale

0.479

High

1274350

DDX21
Nucleolar RNA helicase 2

1

9

High-throughput

0.479

High

1274351

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

8

High-throughput

0.479

High

1274352

SMC4
Structural maintenance of chromosomes protein 4

1

2

High-throughput

0.479

High

1274358

HECW2
E3 ubiquitin-protein ligase HECW2

1

8

High-throughput

0.479

High

1274363

HECD1
E3 ubiquitin-protein ligase HECTD1

1

10

High-throughput

0.479

High

1274364

PRP19
Pre-mRNA-processing factor 19

1

12

High-throughput

0.479

High

1274366

RUVB1
RuvB-like 1

1

4

High-throughput

0.479

High

1274367

TR150
Thyroid hormone receptor-associated protein 3

1

9

High-throughput

0.479

High

1274371

PKP3
Plakophilin-3

1

12

High-throughput

0.479

High

266496

SUPT3
Transcription initiation protein SPT3 homolog

1

0

Small-scale

0.458

High

529515

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.458

High

671300

RL12
Large ribosomal subunit protein uL11

1

0

High-throughput

0.458

High

898419

RS3A
Small ribosomal subunit protein eS1

1

0

High-throughput

0.458

High

907722

RS15A
Small ribosomal subunit protein uS8

1

0

High-throughput

0.458

High

913932

RPB7
DNA-directed RNA polymerase II subunit RPB7

1

0

High-throughput

0.458

High

1274342

PDIP3
Polymerase delta-interacting protein 3

1

0

High-throughput

0.458

High

1274346

STN1
CST complex subunit STN1

1

0

High-throughput

0.458

High

1274369

NOP58
Nucleolar protein 58

1

0

High-throughput

0.458

High

1274373

SCC4
MAU2 chromatid cohesion factor homolog

1

0

High-throughput

0.458

High

62634

A6NG10
WW domain binding protein 2

1

1

High-throughput

0.445

High

73035

B4DUB1
cDNA FLJ50029, highly similar to Cell division cycle 2-like protein kinase 6

1

12

High-throughput

0.445

High

91304

E5RFK5
Cyclin-C

1

6

High-throughput

0.445

High

92485

E9PGW7
Mediator of RNA polymerase II transcription subunit 22

1

2

High-throughput

0.445

High

1274334

NUDC1
NudC domain-containing protein 1

1

1

High-throughput

0.445

High

1274335

CDC5L
Cell division cycle 5-like protein

1

9

High-throughput

0.445

High

1274372

TRRAP
Transformation/transcription domain-associated protein

1

5

Small-scale

0.445

High

323940

BAG2
BAG family molecular chaperone regulator 2

1

3

High-throughput

0.437

High

385303

NTRK1
High affinity nerve growth factor receptor

1

18

High-throughput

0.437

High

1171105

TRI67
Tripartite motif-containing protein 67

1

8

High-throughput

0.437

High

1274329

DDX27
Probable ATP-dependent RNA helicase DDX27

1

9

High-throughput

0.437

High

1274345

PKHA4
Pleckstrin homology domain-containing family A member 4

1

9

High-throughput

0.437

High

1274365

G3BP2
Ras GTPase-activating protein-binding protein 2

1

5

High-throughput

0.437

High

1274357

PP4RL
Putative serine/threonine-protein phosphatase 4 regulatory subunit 1-like

1

3

High-throughput

0.407

High

1129977

COX20
Cytochrome c oxidase assembly protein COX20, mitochondrial

1

0

High-throughput

0.279

Low

821347

TCPE
T-complex protein 1 subunit epsilon

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024