Interactor 1: GCYA2 (P33402)
Guanylate cyclase soluble subunit alpha-2 (GCS-alpha-2) (EC 4.6.1.2)
Gene: GUCY1A2

Interactor 2: GCYB1 (Q02153)
Guanylate cyclase soluble subunit beta-1 (GCS-beta-1) (EC 4.6.1.2) (Guanylate cyclase soluble subunit beta-3) (GCS-beta-3) (Soluble guanylate cyclase small subunit)
Gene: GUCY1B1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.74 1.00 0.861

The method score is based on:

Property Details
Experiments 28514442, 33961781, 11572861
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Guanylate_cyc~Guanylate_cyc, Guanylate_cyc~HNOBA, HNOB~HNOB, HNOB~HNOBA, HNOBA~HNOBA
Common GO terms GO:0004383 - guanylate cyclase activity
GO:0005525 - GTP binding
GO:0005829 - cytosol
GO:0007263 - nitric oxide mediated signal transduction
GO:0008074 - guanylate cyclase complex, soluble
and 3 others

more...

Homologous interactions 8

Homologous interactions

Color coding for hit scores

1 732
Hs

1 619
+ Hs
+ Hs
+ Dm
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024