HitPredict

Interactor 1: CKS2 (P33552)
Cyclin-dependent kinases regulatory subunit 2 (CKS-2)
Gene: CKS2

Interactor 2: CDK9 (P50750)
Cyclin-dependent kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (C-2K) (Cell division cycle 2-like protein kinase 4) (Cell division protein kinase 9) (Serine/threonine-protein kinase PITALRE) (Tat-associated kinase complex catalytic subunit)
Gene: CDK9

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	36736316
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	CKS~Pkinase
Common GO terms	GO:0003682 - chromatin binding GO:0019901 - protein kinase binding
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 79 Hs			1 372
+	Hs
		625283 CKS1_HUMAN (1-79): 1.09e-39: 127: 81.01		CDK2_HUMAN (16-321): 4.46e-136: 391: 38.76
+	Hs
		895456 CKS1_HUMAN (1-79): 1.09e-39: 127: 81.01		CDK12_HUMAN (16-371): 1.16e-123: 390: 42.54
+	Hs
		895413 CKS1_HUMAN (1-79): 1.09e-39: 127: 81.01		CDK3_HUMAN (16-332): 1.8e-134: 387: 37.11
+	Hs
		625164 CKS2_HUMAN (1-79): 8.58e-38: 122: 100.00		CDK2_HUMAN (16-321): 4.46e-136: 391: 38.76
+	Hs
		706817 CKS2_HUMAN (1-79): 8.58e-38: 122: 100.00		CDK12_HUMAN (16-371): 1.16e-123: 390: 42.54
+	Hs
		706796 CKS2_HUMAN (1-79): 8.58e-38: 122: 100.00		CDK3_HUMAN (16-332): 1.8e-134: 387: 37.11
+	Hs
		414843 CKS1_HUMAN (1-79): 1.09e-39: 127: 81.01		CDK1_HUMAN (16-315): 5.07e-124: 361: 40.40
+	Hs
		414778 CKS2_HUMAN (1-79): 8.58e-38: 122: 100.00		CDK1_HUMAN (16-315): 5.07e-124: 361: 40.40
+	Dm
		618415 Q9VHN1_DROME (1-71): 3.94e-38: 123: 69.01		CDK1_DROME (16-315): 1.74e-121: 354: 38.41
+	At
		621728 CKS2_ARATH (5-78): 2.49e-39: 126: 66.22		CDKA1_ARATH (16-317): 2.48e-120: 351: 38.16
+	At
		188136 CKS1_ARATH (5-73): 5.91e-38: 123: 68.12		CDKA1_ARATH (16-317): 2.48e-120: 351: 38.16
+	Hs
		895414 CKS1_HUMAN (1-79): 1.09e-39: 127: 81.01		CDK5_HUMAN (16-321): 3.24e-118: 346: 39.74
+	At
		1321252 CKS2_ARATH (5-78): 2.49e-39: 126: 66.22		CDKD2_ARATH (1-348): 1.92e-117: 346: 37.36
+	Dm
		618387 CKS1_DROME (3-72): 1.5e-35: 116: 77.14		CDK1_DROME (16-315): 1.74e-121: 354: 38.41
+	At
		188163 CKS1_ARATH (5-73): 5.91e-38: 123: 68.12		CDKD2_ARATH (1-348): 1.92e-117: 346: 37.36
+	Hs
		706797 CKS2_HUMAN (1-79): 8.58e-38: 122: 100.00		CDK5_HUMAN (16-321): 3.24e-118: 346: 39.74