HitPredict

Interactor 1: RYK (P34925)
Tyrosine-protein kinase RYK (EC 2.7.10.1)
Gene: RYK

Interactor 2: CD276 (Q5ZPR3)
CD276 antigen (4Ig-B7-H3) (B7 homolog 3) (B7-H3) (Costimulatory molecule) (CD antigen CD276)
Gene: CD276

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	33961781, 21875946
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 607 Hs			1 534
+	Hs
		713860 RYK_HUMAN (1-607): 1.73e-146: 438: 100.00		KIRR1_HUMAN (10-529): 1.49e-67: 233: 13.88
+	Hs
		384783 NTRK1_HUMAN (122-607): 2.22e-129: 400: 25.65		BT1A1_HUMAN (26-244): 1.22e-74: 247: 28.57
+	Hs
		507819 FGFR1_HUMAN (137-599): 4.53e-145: 441: 27.29		NCAM1_HUMAN (149-533): 2.2e-48: 181: 14.50
+	Hs
		530154 RYK_HUMAN (1-607): 1.73e-146: 438: 100.00		NCAM1_HUMAN (149-533): 2.2e-48: 181: 14.50
+	Hs
		608212 FGFR4_HUMAN (137-604): 9.44e-129: 398: 26.10		ROBO1_HUMAN (139-533): 1.17e-55: 204: 14.21
+	Hs
		411521 INSR_HUMAN (237-598): 1.43e-108: 357: 29.40		BTNL2_HUMAN (14-485): 7.66e-68: 228: 24.17
+	Hs
		384188 NTRK1_HUMAN (122-607): 2.22e-129: 400: 25.65		NCAM1_HUMAN (149-533): 2.2e-48: 181: 14.50
+	Hs
		530148 FGFR4_HUMAN (137-604): 9.44e-129: 398: 26.10		NCAM1_HUMAN (149-533): 2.2e-48: 181: 14.50
+	Dr
		47562 A0A8M3B3N4_DANRE (137-598): 1.02e-137: 420: 26.26		F1QSA4_DANRE (25-529): 5.36e-34: 138: 14.54
+	Hs
		385273 NTRK1_HUMAN (122-607): 2.22e-129: 400: 25.65		PXDN_HUMAN (23-359): 1.07e-39: 156: 16.86
+	Hs
		713792 RYK_HUMAN (1-607): 1.73e-146: 438: 100.00		CNTN1_HUMAN (219-533): 4.49e-15: 80.4: 14.72
+	Hs
		507951 FGFR1_HUMAN (137-599): 4.53e-145: 441: 27.29		PGBM_HUMAN (361-488): 1.5e-11: 69.7: 18.94
+	Hs
		609252 FGFR3_HUMAN (137-601): 1.51e-144: 440: 27.04		PGBM_HUMAN (361-488): 1.5e-11: 69.7: 18.94
+	Mm
		530201 NTRK2_MOUSE (15-607): 2.45e-130: 403: 22.33		NCAM1_MOUSE (36-494): 3.26e-19: 93.6: 12.10
+	Hs
		523211 SRC_HUMAN (315-602): 2.06e-108: 338: 30.80		TUTLB_HUMAN (252-532): 1.63e-36: 147: 16.33
+	Hs
		433507 YES_HUMAN (315-602): 3.09e-108: 337: 31.14		TUTLB_HUMAN (252-532): 1.63e-36: 147: 16.33
+	Hs
		385252 NTRK1_HUMAN (122-607): 2.22e-129: 400: 25.65		TITIN_HUMAN (57-462): 8.86e-10: 63.9: 10.02
+	Hs
		981930 RON_HUMAN (265-603): 6.53e-60: 218: 36.96		BTNL2_HUMAN (14-485): 7.66e-68: 228: 24.17
+	Hs
		234508 MERTK_HUMAN (213-604): 8.65e-113: 362: 31.99		DSCAM_HUMAN (309-480): 3.65e-12: 71.6: 16.29
+	Hs
		981901 RON_HUMAN (265-603): 6.53e-60: 218: 36.96		TITIN_HUMAN (57-462): 8.86e-10: 63.9: 10.02