HitPredict

Interactor 1: HSP74 (P34932)
Heat shock 70 kDa protein 4 (HSP70RY) (Heat shock 70-related protein APG-2) (Heat shock protein family H member 2)
Gene: HSPA4

Interactor 2: TTC3 (P53804)
E3 ubiquitin-protein ligase TTC3 (EC 2.3.2.27) (Protein DCRR1) (RING finger protein 105) (RING-type E3 ubiquitin transferase TTC3) (TPR repeat protein D) (Tetratricopeptide repeat protein 3) (TPR repeat protein 3)
Gene: TTC3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.50	0.60	0.552

Property	Details
Experiments	29290964
Identification Methods	two hybrid, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 840 Hs			1 2025
+	Hs
		714148 HSP74_HUMAN (1-840): 0: 993: 100.00		PPP5_HUMAN (220-360): 6.34e-43: 167: 29.79
+	Hs
		714418 HSP74_HUMAN (1-840): 0: 993: 100.00		RPAP3_HUMAN (167-474): 7.92e-34: 142: 19.62
+	Hs
		684440 HSP74_HUMAN (1-840): 0: 993: 100.00		STIP1_HUMAN (74-510): 1.57e-24: 112: 13.23
+	Hs
		213491 HSP74_HUMAN (1-840): 0: 993: 100.00		SGTA_HUMAN (220-333): 1.13e-24: 108: 29.83
+	Hs
		320819 HS74L_HUMAN (1-840): 0: 959: 63.21		STIP1_HUMAN (74-510): 1.57e-24: 112: 13.23
+	Hs
		213427 HS74L_HUMAN (1-840): 0: 959: 63.21		SGTA_HUMAN (220-333): 1.13e-24: 108: 29.83
+	Hs
		714375 HSP74_HUMAN (1-840): 0: 993: 100.00		DNJC7_HUMAN (133-395): 1.18e-09: 65: 16.23
+	Hs
		684925 HS105_HUMAN (1-840): 0: 938: 62.95		STIP1_HUMAN (74-510): 1.57e-24: 112: 13.23
+	At
		99225 HS701_ARATH (2-604): 0: 815: 32.57		OE64M_ARATH (21-346): 1.9e-56: 210: 16.67
+	Hs
		320902 HS74L_HUMAN (1-840): 0: 959: 63.21		DNJC7_HUMAN (133-395): 1.18e-09: 65: 16.23
+	At
		612321 HS701_ARATH (2-604): 0: 815: 32.57		OE64C_ARATH (21-344): 6.43e-55: 205: 18.06
+	Hs
		1267736 HS105_HUMAN (1-840): 0: 938: 62.95		DNJC7_HUMAN (133-395): 1.18e-09: 65: 16.23
+	Dm
		1371973 Q9VUC1_DROME (1-840): 0: 821: 42.10		Q9VPN5_DROME (139-421): 5.02e-30: 128: 17.31
+	Ce
		183700 HSP1_CAEEL (2-603): 0: 811: 31.48		STIP1_CAEEL (229-404): 2.13e-25: 110: 27.27
+	Sc
		696097 HSP79_YEAST (5-697): 5.63e-139: 429: 38.18		SGT2_YEAST (226-361): 5.07e-26: 113: 27.08
+	Sc
		695762 HSP7F_YEAST (5-697): 5.7e-137: 424: 37.61		SGT2_YEAST (226-361): 5.07e-26: 113: 27.08
+	Sc
		549718 HSP79_YEAST (5-697): 5.63e-139: 429: 38.18		STI1_YEAST (204-465): 1.99e-15: 84.1: 16.42
+	Sc
		549717 HSP7F_YEAST (5-697): 5.7e-137: 424: 37.61		STI1_YEAST (204-465): 1.99e-15: 84.1: 16.42
+	Sc
		422998 HSP7F_YEAST (5-697): 5.7e-137: 424: 37.61		TOM70_YEAST (162-489): 2.91e-13: 77: 9.28
+	Hs
		174578 HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92		OGT1_HUMAN (81-443): 8.81e-20: 98.9: 10.24