Protein: PPM1A
Protein phosphatase 1A (EC 3.1.3.16) (Protein phosphatase 2C isoform alpha) (PP2C-alpha) (Protein phosphatase IA)

Gene: PPM1A
Organism: Homo sapiens
Interactions: 150
UniProt ID: P35813

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000287 - magnesium ion binding
GO:0004722 - protein serine/threonine phosphatase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

290877

PPM1B
Protein phosphatase 1B

3

2

High-throughput

0.861

High

776963

MK14
Mitogen-activated protein kinase 14

2

12

Small-scale

0.776

High

703462

MK01
Mitogen-activated protein kinase 1

1

12

Small-scale

0.734

High

354571

PAK4
Serine/threonine-protein kinase PAK 4

1

11

High-throughput

0.691

High

776965

CERKL
Ceramide kinase-like protein

3

1

High-throughput

0.662

High

603188

KPCA
Protein kinase C alpha type

1

1

Small-scale

0.647

High

776949

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

1

11

Small-scale

0.647

High

776950

PAK1
Serine/threonine-protein kinase PAK 1

1

14

Small-scale

0.647

High

776951

PAK2
Serine/threonine-protein kinase PAK 2

1

11

Small-scale

0.647

High

776972

MRCKA
Serine/threonine-protein kinase MRCK alpha

1

4

Small-scale

0.647

High

777036

MRCKB
Serine/threonine-protein kinase MRCK beta

1

6

Small-scale

0.647

High

187301

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

3

0

High-throughput

0.638

High

346758

CER1
Cerberus

3

0

High-throughput

0.638

High

777020

GDF3
Growth/differentiation factor 3

3

0

High-throughput

0.638

High

776935

AL3B1
Aldehyde dehydrogenase family 3 member B1

3

0

High-throughput

0.634

High

271678

HIP1R
Huntingtin-interacting protein 1-related protein

2

1

High-throughput

0.628

High

776986

FXL14
F-box/LRR-repeat protein 14

2

1

High-throughput

0.628

High

777011

PLK3
Serine/threonine-protein kinase PLK3

1

17

Small-scale

0.621

High

436623

KPCB
Protein kinase C beta type

1

1

Small-scale

0.618

High

776940

CDK9
Cyclin-dependent kinase 9

1

10

Small-scale

0.618

High

415391

HSPB1
Heat shock protein beta-1

2

0

High-throughput

0.605

High

777008

BSSP4
Brain-specific serine protease 4

3

1

High-throughput

0.604

High

776937

SYQ
Glutamine--tRNA ligase

2

0

High-throughput

0.602

High

776980

UBE3D
E3 ubiquitin-protein ligase E3D

2

0

High-throughput

0.602

High

777024

HAOX2
2-Hydroxyacid oxidase 2

2

0

High-throughput

0.602

High

774746

TIMP3
Metalloproteinase inhibitor 3

2

1

High-throughput

0.601

High

219802

CHSTA
Carbohydrate sulfotransferase 10

2

0

High-throughput

0.585

High

777027

RTEL1
Regulator of telomere elongation helicase 1

2

0

High-throughput

0.585

High

776993

TRI52
E3 ubiquitin-protein ligase TRIM52

2

1

Small-scale

0.584

High

362882

EGFR
Epidermal growth factor receptor

1

10

High-throughput

0.582

High

465433

IGF1R
Insulin-like growth factor 1 receptor

1

7

High-throughput

0.582

High

776936

MP2K4
Dual specificity mitogen-activated protein kinase kinase 4

1

9

Small-scale

0.575

High

776943

MP2K6
Dual specificity mitogen-activated protein kinase kinase 6

1

11

Small-scale

0.575

High

777013

ZDH11
Palmitoyltransferase ZDHHC11

2

1

High-throughput

0.574

High

186514

TRI18
E3 ubiquitin-protein ligase Midline-1

1

3

Small-scale

0.561

High

776961

SMAD2
Mothers against decapentaplegic homolog 2

1

2

Small-scale

0.561

High

777012

RANB3
Ran-binding protein 3

1

0

Small-scale

0.554

High

529224

TAU
Microtubule-associated protein tau

2

1

High-throughput

0.552

High

777010

IL25
Interleukin-25

2

1

High-throughput

0.549

High

776941

CAV2
Caveolin-2

2

0

High-throughput

0.547

High

410669

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

11

High-throughput

0.541

High

641132

FGFR2
Fibroblast growth factor receptor 2

1

7

High-throughput

0.541

High

641502

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

14

High-throughput

0.541

High

652458

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

1

2

High-throughput

0.541

High

776934

VGFR2
Vascular endothelial growth factor receptor 2

1

6

High-throughput

0.541

High

776948

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

11

High-throughput

0.541

High

776952

PTK7
Inactive tyrosine-protein kinase 7

1

4

High-throughput

0.541

High

776959

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

10

High-throughput

0.541

High

776976

LMTK1
Serine/threonine-protein kinase LMTK1

1

13

High-throughput

0.541

High

776983

LMTK2
Serine/threonine-protein kinase LMTK2

1

15

High-throughput

0.541

High

777031

ALK
ALK tyrosine kinase receptor

1

8

High-throughput

0.541

High

361146

SODC
Superoxide dismutase [Cu-Zn]

1

1

High-throughput

0.536

High

640787

VDAC1
Non-selective voltage-gated ion channel VDAC1

1

1

High-throughput

0.536

High

690789

1433T
14-3-3 protein theta

1

2

High-throughput

0.536

High

732451

ARRB2
Beta-arrestin-2

1

3

High-throughput

0.536

High

773809

SOAT1
Sterol O-acyltransferase 1

1

2

High-throughput

0.536

High

776938

ARRB1
Beta-arrestin-1

1

3

High-throughput

0.536

High

776946

1433Z
14-3-3 protein zeta/delta

1

2

High-throughput

0.536

High

776955

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

2

High-throughput

0.536

High

776975

HSDL2
Hydroxysteroid dehydrogenase-like protein 2

1

1

High-throughput

0.536

High

776991

GCN1
Stalled ribosome sensor GCN1

1

2

High-throughput

0.536

High

777000

RB40C
Ras-related protein Rab-40C

1

1

High-throughput

0.536

High

777004

RSLBB
Ras-like protein family member 11B

1

1

High-throughput

0.536

High

777014

ARP5
Actin-related protein 5

1

3

High-throughput

0.536

High

777017

CABP2
Calcium-binding protein 2

1

3

High-throughput

0.536

High

776958

GRM3
Metabotropic glutamate receptor 3

1

0

Small-scale

0.529

High

428628

RLA0
Large ribosomal subunit protein uL10

1

0

High-throughput

0.518

High

776954

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

2

High-throughput

0.515

High

166626

BCKD
Branched-chain alpha-ketoacid dehydrogenase kinase

1

0

High-throughput

0.513

High

424798

ADT2
ADP/ATP translocase 2

1

0

High-throughput

0.513

High

559245

XRCC5
X-ray repair cross-complementing protein 5

1

0

High-throughput

0.513

High

776942

DHB4
Peroxisomal multifunctional enzyme type 2

1

0

High-throughput

0.513

High

776969

TOIP1
Torsin-1A-interacting protein 1

1

0

High-throughput

0.513

High

776970

TMM31
Transmembrane protein 31

1

0

High-throughput

0.513

High

776982

SLN11
Schlafen family member 11

1

0

High-throughput

0.513

High

776985

DCP1B
mRNA-decapping enzyme 1B

1

0

High-throughput

0.513

High

776990

NEDD1
Protein NEDD1

1

0

High-throughput

0.513

High

776997

HSFY1
Heat shock transcription factor, Y-linked

1

0

High-throughput

0.513

High

777001

PIGS
GPI-anchor transamidase component PIGS

1

0

High-throughput

0.513

High

777002

IWS1
Protein IWS1 homolog

1

0

High-throughput

0.513

High

777016

E41L5
Band 4.1-like protein 5

1

0

High-throughput

0.513

High

777023

FANCI
Fanconi anemia group I protein

1

0

High-throughput

0.513

High

776947

SMAD3
Mothers against decapentaplegic homolog 3

1

2

Small-scale

0.501

High

776957

RRP5
Protein RRP5 homolog

1

0

High-throughput

0.493

High

776995

COQ2
4-hydroxybenzoate polyprenyltransferase, mitochondrial

1

1

High-throughput

0.489

High

181064

AXIN1
Axin-1

1

0

Small-scale

0.479

High

257363

PAGE4
P antigen family member 4

1

1

High-throughput

0.479

High

439669

INSR
Insulin receptor

1

7

High-throughput

0.479

High

603861

CXA1
Gap junction alpha-1 protein

1

1

Small-scale

0.479

High

776945

UBC12
NEDD8-conjugating enzyme Ubc12

1

2

High-throughput

0.479

High

776956

RBM39
RNA-binding protein 39

1

1

High-throughput

0.479

High

776962

SMAD1
Mothers against decapentaplegic homolog 1

1

2

Small-scale

0.479

High

776981

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

1

High-throughput

0.479

High

776989

NUP43
Nucleoporin Nup43

1

3

High-throughput

0.479

High

776994

BICD1
Protein bicaudal D homolog 1

1

1

High-throughput

0.479

High

776996

TRI47
E3 ubiquitin-protein ligase TRIM47

1

1

Small-scale

0.479

High

777005

GRWD1
Glutamate-rich WD repeat-containing protein 1

1

3

High-throughput

0.479

High

777015

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

1

High-throughput

0.479

High

777018

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

1

High-throughput

0.479

High

777021

DUS22
Dual specificity protein phosphatase 22

1

1

High-throughput

0.479

High

777029

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

777030

FBW1B
F-box/WD repeat-containing protein 11

1

2

High-throughput

0.479

High

777032

DUS12
Dual specificity protein phosphatase 12

1

1

High-throughput

0.479

High

156598

DC1I1
Cytoplasmic dynein 1 intermediate chain 1

1

0

High-throughput

0.458

High

226718

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

1

0

Small-scale

0.458

High

293300

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

588060

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

767555

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

776939

5NTC
Cytosolic purine 5'-nucleotidase

1

0

High-throughput

0.458

High

776966

SGO2
Shugoshin 2

1

0

Small-scale

0.458

High

776967

SGO1
Shugoshin 1

1

0

Small-scale

0.458

High

776973

RN123
E3 ubiquitin-protein ligase RNF123

1

0

High-throughput

0.458

High

776978

MOB2
MOB kinase activator 2

1

0

High-throughput

0.458

High

776998

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

776999

ASB2
Ankyrin repeat and SOCS box protein 2

1

0

High-throughput

0.458

High

777003

INT14
Integrator complex subunit 14

1

0

High-throughput

0.458

High

777009

NIF3L
NIF3-like protein 1

1

0

High-throughput

0.458

High

710100

EPHA2
Ephrin type-A receptor 2

1

3

High-throughput

0.457

High

142288

PEX7
Peroxisomal targeting signal 2 receptor

1

2

High-throughput

0.445

High

330060

VENTX
Homeobox protein VENTX

1

1

High-throughput

0.445

High

404707

PRIO
Major prion protein

1

1

High-throughput

0.445

High

628606

CAP7
Azurocidin

1

3

High-throughput

0.445

High

776984

DND1
Dead end protein homolog 1

1

1

High-throughput

0.445

High

777022

DDX28
Probable ATP-dependent RNA helicase DDX28

1

1

High-throughput

0.445

High

777034

GAB2
GRB2-associated-binding protein 2

1

1

High-throughput

0.445

High

105466

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

776977

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.437

High

764488

CTNB1
Catenin beta-1

1

0

Small-scale

0.426

High

776960

DHC24
Delta(24)-sterol reductase

1

0

High-throughput

0.426

High

776979

HS2ST
Heparan sulfate 2-O-sulfotransferase 1

1

0

High-throughput

0.426

High

776992

DVL3
Segment polarity protein dishevelled homolog DVL-3

1

0

Small-scale

0.426

High

777019

ITM2C
Integral membrane protein 2C

1

0

High-throughput

0.426

High

776953

RM49
Large ribosomal subunit protein mL49

1

1

High-throughput

0.407

High

777006

PIGQ
Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q

1

1

High-throughput

0.407

High

776944

ATS12
A disintegrin and metalloproteinase with thrombospondin motifs 12

3

0

High-throughput

0.347

High

776968

RNS13
Probable inactive ribonuclease-like protein 13

3

0

High-throughput

0.347

High

175519

TCPR2
Tectonin beta-propeller repeat-containing protein 2

2

0

High-throughput

0.328

High

776964

MTEF2
Transcription termination factor 2, mitochondrial

2

0

High-throughput

0.328

High

776987

GALD1
Glutamine amidotransferase-like class 1 domain-containing protein 1

2

0

High-throughput

0.328

High

777035

INSL6
Insulin-like peptide INSL6

2

0

High-throughput

0.328

High

142203

CCL22
C-C motif chemokine 22

1

0

High-throughput

0.279

Low

329226

LETM1
Mitochondrial proton/calcium exchanger protein

1

0

High-throughput

0.279

Low

776974

ISK14
Serine protease inhibitor Kazal-type 14

1

0

High-throughput

0.279

Low

776988

WFD11
Protein WFDC11

1

0

High-throughput

0.279

Low

777025

UGGG1
UDP-glucose:glycoprotein glucosyltransferase 1

1

0

High-throughput

0.279

Low

777026

IL20
Interleukin-20

1

0

High-throughput

0.279

Low

777033

PA2GD
Group IID secretory phospholipase A2

1

0

High-throughput

0.279

Low

777007

LXN
Latexin

1

0

High-throughput

0.269

Low

777028

PEF1
Peflin

1

0

Small-scale

0.249

Low

776971

PRAM5
PRAME family member 5

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025