HitPredict

Interactor 1: AQP1 (P29972)
Aquaporin-1 (AQP-1) (Aquaporin-CHIP) (Channel-like integral membrane protein of 28 kDa) (Urine water channel)
Gene: AQP1

Interactor 2: AQP6 (Q13520)
Aquaporin-6 (AQP-6) (Aquaporin-2-like) (Kidney-specific aquaporin) (hKID)
Gene: AQP6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	1.00	0.783

Property	Details
Experiments	32296183, unassigned1304
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	MIP~MIP
Common GO terms	GO:0003097 - renal water transport GO:0008519 - ammonium channel activity GO:0015250 - water channel activity GO:0015670 - carbon dioxide transport GO:0035379 - carbon dioxide transmembrane transporter activity and 1 others more... GO:0042476 - odontogenesis
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 269 Hs			1 282
+	Hs
		715876 AQP1_HUMAN (1-269): 1.16e-99: 293: 100.00		AQP1_HUMAN (14-272): 3.45e-87: 262: 41.79
+	Hs
		936146 AQP4_HUMAN (9-266): 1.88e-89: 269: 43.46		AQP4_HUMAN (6-271): 7.91e-89: 268: 37.96
+	At
		847294 PIP22_ARATH (2-237): 4.4e-89: 267: 42.74		PIP27_ARATH (2-249): 6.99e-90: 269: 31.94
+	At
		1184588 PIP14_ARATH (3-233): 6.63e-88: 264: 41.84		PIP28_ARATH (2-249): 5.5e-90: 270: 34.60
+	At
		847050 PIP22_ARATH (2-237): 4.4e-89: 267: 42.74		PIP21_ARATH (2-255): 4.96e-89: 267: 31.27
+	At
		1020337 PIP14_ARATH (3-233): 6.63e-88: 264: 41.84		PIP27_ARATH (2-249): 6.99e-90: 269: 31.94
+	At
		847299 PIP22_ARATH (2-237): 4.4e-89: 267: 42.74		PIP14_ARATH (2-237): 4.48e-88: 265: 34.26
+	At
		847049 PIP21_ARATH (3-237): 4.94e-88: 264: 44.13		PIP21_ARATH (2-255): 4.96e-89: 267: 31.27
+	At
		847097 PIP14_ARATH (3-233): 6.63e-88: 264: 41.84		PIP21_ARATH (2-255): 4.96e-89: 267: 31.27
+	At
		719092 PIP21_ARATH (3-237): 4.94e-88: 264: 44.13		PIP23_ARATH (2-255): 5.82e-88: 265: 30.55
+	At
		719097 PIP14_ARATH (3-233): 6.63e-88: 264: 41.84		PIP23_ARATH (2-255): 5.82e-88: 265: 30.55
+	At
		847295 PIP22_ARATH (2-237): 4.4e-89: 267: 42.74		PIP12_ARATH (2-237): 5.42e-87: 262: 34.26
+	At
		1184587 PIP14_ARATH (3-233): 6.63e-88: 264: 41.84		PIP25_ARATH (2-248): 2.29e-87: 263: 32.46
+	At
		1056031 PIP14_ARATH (3-233): 6.63e-88: 264: 41.84		PIP12_ARATH (2-237): 5.42e-87: 262: 34.26
+	At
		847296 PIP22_ARATH (2-237): 4.4e-89: 267: 42.74		PIP13_ARATH (2-237): 4.42e-82: 250: 34.26
+	At
		847300 PIP22_ARATH (2-237): 4.4e-89: 267: 42.74		PIP15_ARATH (17-237): 5.86e-82: 250: 35.17
+	At
		1064760 PIP14_ARATH (3-233): 6.63e-88: 264: 41.84		PIP13_ARATH (2-237): 4.42e-82: 250: 34.26
+	At
		847074 PIP21_ARATH (3-237): 4.94e-88: 264: 44.13		PIP11_ARATH (2-237): 2.16e-82: 250: 34.26