HitPredict

Interactor 1: 2AAA (P30153)
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PP2Aa) (Medium tumor antigen-associated 61 kDa protein) (PP2A subunit A isoform PR65-alpha) (PP2A subunit A isoform R1-alpha)
Gene: PPP2R1A

Interactor 2: 2AAB (P30154)
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (PP2A subunit A isoform PR65-beta) (PP2A subunit A isoform R1-beta)
Gene: PPP2R1B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	1.00	0.965

The method score is based on:

Property	Details
Experiments	26496610, 17540176, 18782753, 33961781, 34349018, 36652389, 23443559, unassigned3799
Identification Methods	affinity chromatography technology, cross-linking study, anti tag coimmunoprecipitation
Interaction Type	physical association, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	HEAT~HEAT, HEAT~HEAT_2, HEAT~PPP2R1A-like_HEAT, HEAT_2~HEAT_2, HEAT_2~PPP2R1A-like_HEAT
Common GO terms	GO:0000159 - protein phosphatase type 2A complex GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0019888 - protein phosphatase regulator activity and 4 others more... GO:0051225 - spindle assembly GO:0051754 - meiotic sister chromatid cohesion, centromeric GO:0070062 - extracellular exosome GO:2001241 - positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1	589
Hs

1	601

Service provided by Combinatics, Japan

Last updated: 11Aug2025