HitPredict

Interactor 1: BMI1 (P35226)
Polycomb complex protein BMI-1 (Polycomb group RING finger protein 4) (RING finger protein 51)
Gene: BMI1

Interactor 2: PCGF3 (Q3KNV8)
Polycomb group RING finger protein 3 (RING finger protein 3A)
Gene: PCGF3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.793

Property	Details
Experiments	24981860, 22493164
Identification Methods	affinity chromatography technology, two hybrid, two hybrid array
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	RAWUL~RAWUL, zf-C3HC4_2~zf-C3HC4_2
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0031519 - PcG protein complex GO:0035102 - PRC1 complex
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 326 Hs			1 242
+	Hs
		717488 BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00		BMI1_HUMAN (3-238): 2.96e-60: 194: 33.76
+	Hs
		717489 BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00		PCGF2_HUMAN (3-238): 5.76e-59: 191: 34.03
+	Mm
		639465 BMI1_MOUSE (1-326): 2.15e-150: 426: 96.93		BMI1_MOUSE (3-238): 5e-59: 191: 33.48
+	Hs
		718150 BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00		PCGF1_HUMAN (3-238): 1.66e-45: 154: 38.33
+	Hs
		718164 BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00		PCGF6_HUMAN (3-235): 4.63e-43: 150: 33.62
+	Hs
		988039 R4GMX3_HUMAN (1-326): 5.65e-157: 449: 100.00		RING1_HUMAN (3-172): 3.16e-35: 131: 20.81
+	Hs
		717977 BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00		PCGF5_HUMAN (4-241): 3.95e-40: 140: 38.06
+	Hs
		718129 BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00		RING2_HUMAN (2-237): 3.42e-36: 132: 18.00
+	Hs
		717742 BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00		RING1_HUMAN (3-172): 3.16e-35: 131: 20.81
+	Mm
		193404 BMI1_MOUSE (1-326): 2.15e-150: 426: 96.93		RING1_MOUSE (3-182): 7.06e-36: 133: 20.22
+	Mm
		639478 BMI1_MOUSE (1-326): 2.15e-150: 426: 96.93		RING2_MOUSE (2-237): 2.47e-36: 132: 18.00
+	Hs
		536741 BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00		TRI27_HUMAN (2-237): 2.45e-31: 122: 12.06
+	Hs
		717765 BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00		TRI26_HUMAN (2-208): 2.66e-31: 122: 15.28
+	Hs
		718402 PCGF2_HUMAN (1-320): 1.04e-117: 344: 61.36		PCGF3_HUMAN (1-242): 8.16e-66: 205: 100.00
+	Hs
		718376 PCGF2_HUMAN (1-320): 1.04e-117: 344: 61.36		PCGF2_HUMAN (3-238): 5.76e-59: 191: 34.03
+	Dr
		1193368 BMI1A_DANRE (1-326): 9.35e-128: 369: 81.29		RING2_DANRE (2-237): 1.62e-36: 133: 17.00
+	Dr
		1186371 BMI1B_DANRE (1-322): 4e-124: 360: 77.23		RING2_DANRE (2-237): 1.62e-36: 133: 17.00
+	Hs
		718406 PCGF2_HUMAN (1-320): 1.04e-117: 344: 61.36		PCGF5_HUMAN (4-241): 3.95e-40: 140: 38.06
+	Hs
		718393 PCGF2_HUMAN (1-320): 1.04e-117: 344: 61.36		RING1_HUMAN (3-172): 3.16e-35: 131: 20.81