HitPredict

Interactor 1: BMI1 (P35226)
Polycomb complex protein BMI-1 (Polycomb group RING finger protein 4) (RING finger protein 51)
Gene: BMI1

Interactor 2: PCGF6 (Q9BYE7)
Polycomb group RING finger protein 6 (Mel18 and Bmi1-like RING finger) (RING finger protein 134)
Gene: PCGF6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.57	1.00	0.757

Property	Details
Experiments	24981860, 12167161
Identification Methods	affinity chromatography technology, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	RAWUL~RAWUL, zf-C3HC4_2~zf-C3HC4_2
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006338 - chromatin remodeling GO:0031519 - PcG protein complex and 1 others more... GO:0035102 - PRC1 complex
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 326 Hs			1 350
+	Hs
		717488 BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00		BMI1_HUMAN (117-349): 8.67e-71: 225: 34.30
+	Mm
		639465 BMI1_MOUSE (1-326): 2.15e-150: 426: 96.93		BMI1_MOUSE (117-349): 7.79e-70: 222: 35.00
+	Hs
		717489 BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00		PCGF2_HUMAN (117-350): 6.32e-65: 211: 33.47
+	Hs
		717887 BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00		PCGF3_HUMAN (120-341): 3.31e-65: 208: 34.44
+	Hs
		718150 BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00		PCGF1_HUMAN (119-347): 3.16e-60: 196: 34.91
+	Hs
		717977 BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00		PCGF5_HUMAN (117-344): 6.93e-50: 169: 31.73
+	Hs
		717765 BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00		TRI26_HUMAN (121-315): 1.51e-31: 126: 19.90
+	Hs
		718129 BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00		RING2_HUMAN (85-303): 3.51e-32: 124: 14.49
+	Hs
		988039 R4GMX3_HUMAN (1-326): 5.65e-157: 449: 100.00		RING1_HUMAN (109-211): 1.44e-25: 108: 25.96
+	Hs
		718376 PCGF2_HUMAN (1-320): 1.04e-117: 344: 61.36		PCGF2_HUMAN (117-350): 6.32e-65: 211: 33.47
+	Hs
		718402 PCGF2_HUMAN (1-320): 1.04e-117: 344: 61.36		PCGF3_HUMAN (120-341): 3.31e-65: 208: 34.44
+	Mm
		639478 BMI1_MOUSE (1-326): 2.15e-150: 426: 96.93		RING2_MOUSE (85-303): 2.38e-32: 125: 14.49
+	Hs
		717742 BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00		RING1_HUMAN (109-211): 1.44e-25: 108: 25.96
+	Mm
		193404 BMI1_MOUSE (1-326): 2.15e-150: 426: 96.93		RING1_MOUSE (109-211): 8.51e-26: 108: 25.96
+	Hs
		718406 PCGF2_HUMAN (1-320): 1.04e-117: 344: 61.36		PCGF5_HUMAN (117-344): 6.93e-50: 169: 31.73
+	Dr
		1193368 BMI1A_DANRE (1-326): 9.35e-128: 369: 81.29		RING2_DANRE (105-303): 2.8e-32: 125: 15.63
+	Dr
		1186371 BMI1B_DANRE (1-322): 4e-124: 360: 77.23		RING2_DANRE (105-303): 2.8e-32: 125: 15.63
+	Hs
		718420 PCGF2_HUMAN (1-320): 1.04e-117: 344: 61.36		RING2_HUMAN (85-303): 3.51e-32: 124: 14.49
+	Hs
		718393 PCGF2_HUMAN (1-320): 1.04e-117: 344: 61.36		RING1_HUMAN (109-211): 1.44e-25: 108: 25.96