HitPredict

Interactor 1: WEE1 (P30291)
Wee1-like protein kinase (WEE1hu) (EC 2.7.10.2) (Wee1A kinase)
Gene: WEE1

Interactor 2: 1433S (P31947)
14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)
Gene: SFN

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.633

Property	Details
Experiments	15778465, 36931259
Identification Methods	affinity chromatography technology, proximity labelling technology, cross-linking study, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 646 Hs			1 248
+	Hs
		719002 WEE1_HUMAN (1-646): 1.94e-180: 528: 100.00		1433E_HUMAN (2-246): 4.43e-146: 410: 60.41
+	Hs
		719004 WEE1_HUMAN (1-646): 1.94e-180: 528: 100.00		1433Z_HUMAN (1-242): 8.34e-142: 398: 70.66
+	Hs
		690757 WEE1_HUMAN (1-646): 1.94e-180: 528: 100.00		1433T_HUMAN (1-238): 1e-107: 312: 71.85
+	Hs
		718988 WEE1_HUMAN (1-646): 1.94e-180: 528: 100.00		1433B_HUMAN (1-239): 3.42e-100: 293: 68.62
+	Hs
		719001 WEE1_HUMAN (1-646): 1.94e-180: 528: 100.00		1433G_HUMAN (1-242): 1.87e-98: 289: 65.16
+	Hs
		728051 AKT1_HUMAN (181-634): 7.3e-124: 377: 16.17		1433S_HUMAN (1-248): 3.5e-158: 440: 100.00
+	Hs
		719009 WEE1_HUMAN (1-646): 1.94e-180: 528: 100.00		1433F_HUMAN (2-242): 2.79e-96: 283: 64.20
+	At
		1030844 CDPK1_ARATH (135-645): 2.09e-128: 393: 16.17		14332_ARATH (3-248): 2.24e-144: 405: 58.47
+	At
		854983 CDPK1_ARATH (135-645): 2.09e-128: 393: 16.17		14334_ARATH (3-248): 1.24e-142: 401: 56.45
+	At
		840556 CDPK1_ARATH (135-645): 2.09e-128: 393: 16.17		14335_ARATH (2-247): 4.56e-140: 395: 56.05
+	Hs
		728147 AKT1_HUMAN (181-634): 7.3e-124: 377: 16.17		1433E_HUMAN (2-246): 4.43e-146: 410: 60.41
+	Hs
		728155 AKT1_HUMAN (181-634): 7.3e-124: 377: 16.17		1433Z_HUMAN (1-242): 8.34e-142: 398: 70.66
+	Hs
		730569 KCC2D_HUMAN (293-630): 1.69e-106: 333: 21.25		1433S_HUMAN (1-248): 3.5e-158: 440: 100.00
+	Hs
		971494 KCC2D_HUMAN (293-630): 1.69e-106: 333: 21.25		1433E_HUMAN (2-246): 4.43e-146: 410: 60.41
+	Mm
		989991 KCC2D_MOUSE (293-630): 1.69e-106: 333: 21.25		1433Z_MOUSE (1-243): 1.35e-136: 385: 69.96
+	Mm
		704208 KCC2B_MOUSE (293-643): 1.8e-102: 324: 23.27		1433Z_MOUSE (1-243): 1.35e-136: 385: 69.96
+	Hs
		728143 AKT1_HUMAN (181-634): 7.3e-124: 377: 16.17		1433G_HUMAN (1-242): 1.87e-98: 289: 65.16
+	Hs
		691549 KCC2A_HUMAN (293-630): 3.7e-102: 321: 21.47		1433T_HUMAN (1-238): 1e-107: 312: 71.85
+	Hs
		966283 KCC2D_HUMAN (293-630): 1.69e-106: 333: 21.25		1433G_HUMAN (1-242): 1.87e-98: 289: 65.16
+	Hs
		730365 KCC2A_HUMAN (293-630): 3.7e-102: 321: 21.47		1433B_HUMAN (1-239): 3.42e-100: 293: 68.62