Protein: WEE1
Wee1-like protein kinase (WEE1hu) (EC 2.7.10.2) (Wee1A kinase)

Gene: WEE1
Organism: Homo sapiens
Interactions: 92
UniProt ID: P30291

Gene Ontology (top 5):
GO:0000086 - G2/M transition of mitotic cell cycle
GO:0000226 - microtubule cytoskeleton organization
GO:0000287 - magnesium ion binding
GO:0004713 - protein tyrosine kinase activity
GO:0004715 - non-membrane spanning protein tyrosine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

443209

CDK1
Cyclin-dependent kinase 1

5

20

Small-scale

0.919

High

718998

PLK1
Serine/threonine-protein kinase PLK1

4

18

Small-scale

0.910

High

667570

CDK2
Cyclin-dependent kinase 2

3

20

Small-scale

0.865

High

573759

CCNB1
G2/mitotic-specific cyclin-B1

2

9

Small-scale

0.799

High

719005

CSK2B
Casein kinase II subunit beta

2

1

Small-scale

0.789

High

718987

AKT1
RAC-alpha serine/threonine-protein kinase

1

17

Small-scale

0.761

High

719046

FBW1B
F-box/WD repeat-containing protein 11

7

12

Small-scale

0.745

High

719007

CCNA1
Cyclin-A1

1

9

Small-scale

0.724

High

718988

1433B
14-3-3 protein beta/alpha

4

20

Small-scale

0.703

High

690757

1433T
14-3-3 protein theta

4

20

Small-scale

0.697

High

719001

1433G
14-3-3 protein gamma

4

20

High-throughput

0.694

High

65239

ZN316
Zinc finger protein 316

1

5

High-throughput

0.691

High

601952

ZNF8
Zinc finger protein 8

1

9

High-throughput

0.691

High

719041

RBAK
RB-associated KRAB zinc finger protein

1

5

High-throughput

0.691

High

719004

1433Z
14-3-3 protein zeta/delta

3

20

High-throughput

0.684

High

719049

FBW1A
F-box/WD repeat-containing protein 1A

3

13

Small-scale

0.678

High

719009

1433F
14-3-3 protein eta

3

20

High-throughput

0.667

High

340298

YETS4
YEATS domain-containing protein 4

4

0

High-throughput

0.664

High

719026

BRSK2
Serine/threonine-protein kinase BRSK2

1

18

Small-scale

0.647

High

719014

SKP2
S-phase kinase-associated protein 2

2

10

Small-scale

0.634

High

718989

1433S
14-3-3 protein sigma

2

20

High-throughput

0.633

High

719015

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

2

4

Small-scale

0.629

High

719030

CCYL1
Cyclin-Y-like protein 1

1

3

High-throughput

0.618

High

240852

PRKN
E3 ubiquitin-protein ligase parkin

1

17

High-throughput

0.618

High

578397

BRAF
Serine/threonine-protein kinase B-raf

1

14

High-throughput

0.618

High

625209

CSK22
Casein kinase II subunit alpha'

1

20

Small-scale

0.618

High

718992

CCNF
Cyclin-F

1

15

High-throughput

0.618

High

718996

KC1A
Casein kinase I isoform alpha

1

15

High-throughput

0.618

High

719006

CSK21
Casein kinase II subunit alpha

1

20

Small-scale

0.618

High

719038

NEK6
Serine/threonine-protein kinase Nek6

1

17

High-throughput

0.618

High

719040

KI13B
Kinesin-like protein KIF13B

1

8

High-throughput

0.618

High

719047

BRPF3
Bromodomain and PHD finger-containing protein 3

2

4

High-throughput

0.611

High

172496

XPO1
Exportin-1

2

15

Small-scale

0.584

High

719023

PAXI1
PAX-interacting protein 1

2

4

Small-scale

0.584

High

718986

WEE1
Wee1-like protein kinase

1

17

Small-scale

0.575

High

719039

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

17

Small-scale

0.561

High

719044

ERRFI
ERBB receptor feedback inhibitor 1

1

8

Small-scale

0.561

High

719048

CC14A
Dual specificity protein phosphatase CDC14A

1

6

Small-scale

0.561

High

189113

IPO8
Importin-8

1

9

High-throughput

0.536

High

334692

IPO7
Importin-7

1

10

High-throughput

0.536

High

501919

H2AZ
Histone H2A.Z

1

20

High-throughput

0.536

High

565787

EF2
Elongation factor 2

1

5

High-throughput

0.536

High

718990

ARRB2
Beta-arrestin-2

1

7

High-throughput

0.536

High

719003

CNBP
CCHC-type zinc finger nucleic acid binding protein

1

1

High-throughput

0.536

High

719008

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

12

High-throughput

0.536

High

719013

TIF1B
Transcription intermediary factor 1-beta

1

13

High-throughput

0.536

High

719017

PCBP1
Poly(rC)-binding protein 1

1

9

High-throughput

0.536

High

719020

CE350
Centrosome-associated protein 350

1

19

High-throughput

0.536

High

719027

WDFY3
WD repeat and FYVE domain-containing protein 3

1

7

High-throughput

0.536

High

719042

POGK
Pogo transposable element with KRAB domain

1

8

High-throughput

0.536

High

719019

H2B2E
Histone H2B type 2-E

1

17

Small-scale

0.516

High

474501

VIME
Vimentin

1

20

High-throughput

0.515

High

719000

PSME3
Proteasome activator complex subunit 3

1

0

High-throughput

0.513

High

718993

EPS15
Epidermal growth factor receptor substrate 15

1

9

High-throughput

0.501

High

718995

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

17

High-throughput

0.501

High

131338

EIF3F
Eukaryotic translation initiation factor 3 subunit F

1

3

High-throughput

0.489

High

719018

AINX
Alpha-internexin

1

19

High-throughput

0.489

High

719034

CDCA3
Cell division cycle-associated protein 3

1

0

Small-scale

0.480

High

174489

TRI66
Tripartite motif-containing protein 66

1

16

High-throughput

0.479

High

243895

JIP4
C-Jun-amino-terminal kinase-interacting protein 4

1

18

High-throughput

0.479

High

403852

GCR
Glucocorticoid receptor

1

17

High-throughput

0.479

High

413263

P53
Cellular tumor antigen p53

1

1

High-throughput

0.479

High

539951

BCR
Breakpoint cluster region protein

1

13

High-throughput

0.479

High

718504

CDC27
Cell division cycle protein 27 homolog

1

11

High-throughput

0.479

High

718991

MCM4
DNA replication licensing factor MCM4

1

7

High-throughput

0.479

High

718994

CRK
Adapter molecule crk

1

9

Small-scale

0.479

High

718997

MCM2
DNA replication licensing factor MCM2

1

10

High-throughput

0.479

High

719002

1433E
14-3-3 protein epsilon

1

9

High-throughput

0.479

High

719010

EP300
Histone acetyltransferase p300

1

7

High-throughput

0.479

High

719012

CDC16
Cell division cycle protein 16 homolog

1

11

High-throughput

0.479

High

719025

CLAP1
CLIP-associating protein 1

1

7

High-throughput

0.479

High

719029

SIR6
NAD-dependent protein deacylase sirtuin-6

1

5

High-throughput

0.479

High

719031

FBXW7
F-box/WD repeat-containing protein 7

1

14

Small-scale

0.479

High

719036

CECR2
Chromatin remodeling regulator CECR2

1

4

High-throughput

0.479

High

719043

CING
Cingulin

1

18

High-throughput

0.479

High

719045

APC7
Anaphase-promoting complex subunit 7

1

11

High-throughput

0.479

High

719050

CBY1
Protein chibby homolog 1

1

1

High-throughput

0.479

High

719051

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

2

High-throughput

0.479

High

719016

NPAT
Protein NPAT

1

0

Small-scale

0.458

High

719022

FBX38
F-box only protein 38

1

0

High-throughput

0.458

High

719033

MUS81
Structure-specific endonuclease subunit MUS81

1

0

Small-scale

0.458

High

719035

NDC1
Nucleoporin NDC1

1

0

High-throughput

0.458

High

391190

FRIL
Ferritin light chain

1

2

High-throughput

0.445

High

719024

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

20

High-throughput

0.445

High

719021

DEN4C
DENN domain-containing protein 4C

1

2

High-throughput

0.437

High

719052

KCTD3
BTB/POZ domain-containing protein KCTD3

1

8

High-throughput

0.437

High

719028

RUSC2
AP-4 complex accessory subunit RUSC2

1

0

High-throughput

0.279

Low

718999

ATP5E
ATP synthase F(1) complex subunit epsilon, mitochondrial

1

0

High-throughput

0.249

Low

719011

NU160
Nuclear pore complex protein Nup160

1

0

High-throughput

0.249

Low

719032

CC138
Coiled-coil domain-containing protein 138

1

0

High-throughput

0.249

Low

719037

CPLN1
Ciliogenesis and planar polarity effector 1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025