HitPredict

Interactor 1: PTN5 (P35234)
Tyrosine-protein phosphatase non-receptor type 5 (EC 3.1.3.48) (Neural-specific protein-tyrosine phosphatase) (Striatum-enriched protein-tyrosine phosphatase) (STEP)
Gene: Ptpn5

Interactor 2: NMDE2 (Q00960)
Glutamate receptor ionotropic, NMDA 2B (GluN2B) (Glutamate [NMDA] receptor subunit epsilon-2) (N-methyl D-aspartate receptor subtype 2B) (NMDAR2B) (NR2B)
Gene: Grin2b

Species: Rattus norvegicus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	27457929, 20427654
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001975 - response to amphetamine GO:0005886 - plasma membrane GO:0008021 - synaptic vesicle GO:0043025 - neuronal cell body GO:0097060 - synaptic membrane
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 369 Rn			1 1482
+	Mm
		873170 PTN5_MOUSE (1-369): 4.3e-164: 471: 98.65		NMDE2_MOUSE (1-1482): 0: 1846: 99.46
+	Hs
		616915 PTPRB_HUMAN (44-369): 2.78e-119: 381: 29.04		NMDE2_HUMAN (1-1482): 0: 1828: 98.38
+	Mm
		719298 PTN11_MOUSE (24-369): 2.1e-119: 359: 30.53		NMDE2_MOUSE (1-1482): 0: 1846: 99.46
+	Hs
		1020091 PTPRJ_HUMAN (71-369): 3.89e-117: 370: 30.82		NMDE2_HUMAN (1-1482): 0: 1828: 98.38
+	Hs
		441195 PTPRC_HUMAN (94-357): 9.65e-78: 261: 26.53		NMDE2_HUMAN (1-1482): 0: 1828: 98.38
+	Hs
		617106 PTPRG_HUMAN (101-365): 2.49e-54: 194: 24.10		NMDE2_HUMAN (1-1482): 0: 1828: 98.38
+	Mm
		723521 PTN5_MOUSE (1-369): 4.3e-164: 471: 98.65		NMDE1_MOUSE (9-1482): 0: 1507: 52.51
+	Rn
		719282 PTN5_RAT (1-369): 2.61e-163: 463: 100.00		NMDE1_RAT (9-1482): 0: 1498: 52.31
+	Rn
		719281 PTN5_RAT (1-369): 2.61e-163: 463: 100.00		NMDZ1_RAT (14-940): 0: 676: 24.14
+	Hs
		616949 PTPRD_HUMAN (100-364): 1.85e-102: 333: 35.66		GRIK1_HUMAN (1-854): 0: 711: 20.17
+	Mm
		719287 PTN11_MOUSE (24-369): 2.1e-119: 359: 30.53		NMDZ1_MOUSE (14-940): 0: 675: 24.04
+	Rn
		723631 Q66HJ7_RAT (88-368): 1.05e-105: 330: 31.94		NMDZ1_RAT (14-940): 0: 676: 24.14
+	Hs
		1060436 PTPRK_HUMAN (96-362): 4.32e-67: 231: 25.54		NMDE3_HUMAN (9-929): 0: 765: 53.95
+	Rn
		585176 PTPRF_RAT (107-364): 6.24e-100: 326: 35.47		GRIA2_RAT (15-871): 0: 661: 21.16
+	Hs
		984265 PTPRK_HUMAN (96-362): 4.32e-67: 231: 25.54		NMDZ1_HUMAN (13-940): 0: 672: 24.12