Protein: PHLB2
Pleckstrin homology-like domain family B member 2 (Protein LL5-beta)

Gene: PHLB2, PHLDB2
Organism: Homo sapiens
Interactions: 151
UniProt ID: Q86SQ0

Gene Ontology (top 5):
GO:0000226 - microtubule cytoskeleton organization
GO:0002102 - podosome
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0005938 - cell cortex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

375669

RASK
GTPase KRas

2

20

High-throughput

0.754

High

978124

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.754

High

1226977

A16L1
Autophagy-related protein 16-1

2

20

High-throughput

0.737

High

730008

1433B
14-3-3 protein beta/alpha

6

20

High-throughput

0.735

High

990423

1433Z
14-3-3 protein zeta/delta

5

20

High-throughput

0.718

High

691187

1433T
14-3-3 protein theta

5

20

High-throughput

0.714

High

966545

1433G
14-3-3 protein gamma

4

20

High-throughput

0.699

High

593422

PGFRA
Platelet-derived growth factor receptor alpha

1

7

High-throughput

0.691

High

1286540

RGAP1
Rac GTPase-activating protein 1

1

16

High-throughput

0.691

High

1049499

1433F
14-3-3 protein eta

3

20

High-throughput

0.667

High

971715

1433E
14-3-3 protein epsilon

2

7

High-throughput

0.635

High

176846

DCLK1
Serine/threonine-protein kinase DCLK1

1

9

High-throughput

0.618

High

269576

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

14

High-throughput

0.618

High

374716

RASH
GTPase HRas

1

18

High-throughput

0.618

High

463618

LYN
Tyrosine-protein kinase Lyn

1

11

High-throughput

0.618

High

466329

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.618

High

581141

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.618

High

710337

EPHA2
Ephrin type-A receptor 2

1

11

High-throughput

0.618

High

936373

AFAD
Afadin

1

20

High-throughput

0.618

High

953533

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

962219

RHOA
Transforming protein RhoA

1

20

High-throughput

0.618

High

988490

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

1006082

DLG4
Disks large homolog 4

1

6

Small-scale

0.618

High

1025565

CDK16
Cyclin-dependent kinase 16

1

17

High-throughput

0.618

High

1065725

CAMP2
Calmodulin-regulated spectrin-associated protein 2

1

20

High-throughput

0.618

High

1092456

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

15

High-throughput

0.618

High

1140492

KIF14
Kinesin-like protein KIF14

1

20

High-throughput

0.618

High

1216066

SPD2A
SH3 and PX domain-containing protein 2A

1

9

High-throughput

0.618

High

1286515

KSR1
Kinase suppressor of Ras 1

1

18

High-throughput

0.618

High

1286543

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.618

High

1286544

ECT2
Protein ECT2

1

20

High-throughput

0.618

High

1286547

ANLN
Anillin

1

9

High-throughput

0.618

High

1286548

LATS2
Serine/threonine-protein kinase LATS2

1

20

High-throughput

0.618

High

1286566

FBW1A
F-box/WD repeat-containing protein 1A

1

17

High-throughput

0.618

High

1286526

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

2

16

High-throughput

0.614

High

537429

HSP7C
Heat shock cognate 71 kDa protein

2

11

High-throughput

0.611

High

637604

FLNA
Filamin-A

2

20

Small-scale

0.611

High

1035739

KIF23
Kinesin-like protein KIF23

2

20

High-throughput

0.611

High

391319

FRIL
Ferritin light chain

2

3

High-throughput

0.601

High

1286538

RTKN
Rhotekin

1

0

High-throughput

0.586

High

889448

CLK1
Dual specificity protein kinase CLK1

1

20

High-throughput

0.579

High

363508

EGFR
Epidermal growth factor receptor

1

11

High-throughput

0.575

High

1286537

LZTS2
Leucine zipper putative tumor suppressor 2

2

17

High-throughput

0.571

High

1125357

FLNC
Filamin-C

1

20

Small-scale

0.561

High

372442

MYC
Myc proto-oncogene protein

2

13

High-throughput

0.558

High

730722

1433S
14-3-3 protein sigma

1

20

High-throughput

0.554

High

245246

MAST3
Microtubule-associated serine/threonine-protein kinase 3

1

14

High-throughput

0.553

High

1216005

M3K21
Mitogen-activated protein kinase kinase kinase 21

1

7

High-throughput

0.553

High

1286546

KI13B
Kinesin-like protein KIF13B

1

17

High-throughput

0.553

High

1286564

AGAP1
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

1

5

High-throughput

0.553

High

123754

MYO1C
Unconventional myosin-Ic

1

18

High-throughput

0.536

High

159724

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

16

High-throughput

0.536

High

290059

OFD1
Centriole and centriolar satellite protein OFD1

1

3

High-throughput

0.536

High

866746

CAZA2
F-actin-capping protein subunit alpha-2

1

9

High-throughput

0.536

High

991596

DYL1
Dynein light chain 1, cytoplasmic

1

6

High-throughput

0.536

High

1052055

CALD1
Caldesmon

1

19

High-throughput

0.536

High

1178599

KIF7
Kinesin-like protein KIF7

1

8

High-throughput

0.536

High

1286517

SYNPO
Synaptopodin

1

16

High-throughput

0.536

High

1286525

MY18A
Unconventional myosin-XVIIIa

1

17

High-throughput

0.536

High

1286530

MYO19
Unconventional myosin-XIX

1

17

High-throughput

0.536

High

1286570

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

1

High-throughput

0.536

High

1286534

TESK2
Dual specificity testis-specific protein kinase 2

1

0

High-throughput

0.517

High

1286514

PATL1
Protein PAT1 homolog 1

1

6

High-throughput

0.515

High

292669

RENR
Renin receptor

1

0

High-throughput

0.513

High

1286516

TXLNB
Beta-taxilin

1

17

High-throughput

0.489

High

1286569

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

3

High-throughput

0.489

High

163990

NDC80
Kinetochore protein NDC80 homolog

1

18

High-throughput

0.479

High

179368

ARPC2
Actin-related protein 2/3 complex subunit 2

1

1

High-throughput

0.479

High

208698

SI1L1
Signal-induced proliferation-associated 1-like protein 1

1

8

High-throughput

0.479

High

272289

OBSL1
Obscurin-like protein 1

1

16

High-throughput

0.479

High

281360

GGYF1
GRB10-interacting GYF protein 1

1

13

High-throughput

0.479

High

299263

FLOT1
Flotillin-1

1

7

High-throughput

0.479

High

323464

TRI37
E3 ubiquitin-protein ligase TRIM37

1

20

High-throughput

0.479

High

556187

CADH1
Cadherin-1

1

8

High-throughput

0.479

High

563999

CFTR
Cystic fibrosis transmembrane conductance regulator

1

14

High-throughput

0.479

High

604065

CXA1
Gap junction alpha-1 protein

1

5

High-throughput

0.479

High

637919

NF1
Neurofibromin

1

11

High-throughput

0.479

High

719238

MPIP2
M-phase inducer phosphatase 2

1

3

High-throughput

0.479

High

719344

MPIP3
M-phase inducer phosphatase 3

1

3

High-throughput

0.479

High

764866

CTNB1
Catenin beta-1

1

13

High-throughput

0.479

High

838460

GRIA1
Glutamate receptor 1

1

7

Small-scale

0.479

High

838499

GRIA2
Glutamate receptor 2

1

7

Small-scale

0.479

High

867250

CAPZB
F-actin-capping protein subunit beta

1

6

High-throughput

0.479

High

941007

HDAC4
Histone deacetylase 4

1

20

High-throughput

0.479

High

1045457

TF65
Transcription factor p65

1

7

High-throughput

0.479

High

1091422

ANK3
Ankyrin-3

1

12

High-throughput

0.479

High

1100867

G3BP1
Ras GTPase-activating protein-binding protein 1

1

6

High-throughput

0.479

High

1134970

CUL7
Cullin-7

1

8

High-throughput

0.479

High

1159725

OCLN
Occludin

1

2

High-throughput

0.479

High

1219595

DEN4C
DENN domain-containing protein 4C

1

4

High-throughput

0.479

High

1226150

CP135
Centrosomal protein of 135 kDa

1

17

High-throughput

0.479

High

1251366

GGYF2
GRB10-interacting GYF protein 2

1

19

High-throughput

0.479

High

1257016

SYDE1
Rho GTPase-activating protein SYDE1

1

18

High-throughput

0.479

High

1278189

CLAP1
CLIP-associating protein 1

1

8

Small-scale

0.479

High

1286518

FBXW8
F-box/WD repeat-containing protein 8

1

18

High-throughput

0.479

High

1286520

F110B
Protein FAM110B

1

2

High-throughput

0.479

High

1286521

DEN1A
DENN domain-containing protein 1A

1

4

High-throughput

0.479

High

1286522

PARD3
Partitioning defective 3 homolog

1

16

High-throughput

0.479

High

1286529

SH3K1
SH3 domain-containing kinase-binding protein 1

1

20

High-throughput

0.479

High

1286532

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

17

High-throughput

0.479

High

1286536

F110A
Protein FAM110A

1

2

High-throughput

0.479

High

1286539

CP250
Centrosome-associated protein CEP250

1

17

High-throughput

0.479

High

1286541

CCDC8
Coiled-coil domain-containing protein 8

1

9

High-throughput

0.479

High

1286542

VP33B
Vacuolar protein sorting-associated protein 33B

1

1

High-throughput

0.479

High

1286549

INP5E
Phosphatidylinositol polyphosphate 5-phosphatase type IV

1

5

High-throughput

0.479

High

1286551

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

1

1

High-throughput

0.479

High

1286552

CING
Cingulin

1

17

High-throughput

0.479

High

1286553

ZRAN1
Ubiquitin thioesterase ZRANB1

1

13

High-throughput

0.479

High

1286554

LIMA1
LIM domain and actin-binding protein 1

1

9

High-throughput

0.479

High

1286556

NGAP
Ras GTPase-activating protein nGAP

1

11

High-throughput

0.479

High

1286558

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

13

High-throughput

0.479

High

1286560

BRPF3
Bromodomain and PHD finger-containing protein 3

1

7

High-throughput

0.479

High

1286561

ZBT21
Zinc finger and BTB domain-containing protein 21

1

3

High-throughput

0.479

High

1286563

MYO6
Unconventional myosin-VI

1

16

High-throughput

0.479

High

1286568

KCTD3
BTB/POZ domain-containing protein KCTD3

1

17

High-throughput

0.479

High

252103

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

0

High-throughput

0.458

High

339090

NADK
NAD kinase

1

0

High-throughput

0.458

High

1286531

RAB3I
Rab-3A-interacting protein

1

0

High-throughput

0.458

High

1286535

SIN1
Target of rapamycin complex 2 subunit MAPKAP1

1

0

High-throughput

0.458

High

1286567

CBY1
Protein chibby homolog 1

1

0

High-throughput

0.458

High

58850

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

3

High-throughput

0.445

High

516547

CALM3
Calmodulin-3

1

6

High-throughput

0.445

High

1023823

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

3

High-throughput

0.445

High

1034017

OCRL
Inositol polyphosphate 5-phosphatase OCRL

1

5

High-throughput

0.445

High

247983

NUPR1
Nuclear protein 1

1

4

High-throughput

0.437

High

331099

KI20A
Kinesin-like protein KIF20A

1

20

High-throughput

0.437

High

1051787

EF1A2
Elongation factor 1-alpha 2

1

2

High-throughput

0.437

High

1133996

ZN638
Zinc finger protein 638

1

7

High-throughput

0.437

High

1156757

E2F4
Transcription factor E2F4

1

1

High-throughput

0.437

High

1229891

AN34A
Ankyrin repeat domain-containing protein 34A

1

17

High-throughput

0.437

High

1254439

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.437

High

1256499

CE128
Centrosomal protein of 128 kDa

1

19

High-throughput

0.437

High

1270295

SPT6H
Transcription elongation factor SPT6

1

9

High-throughput

0.437

High

1272639

DET1
DET1 homolog

1

1

High-throughput

0.437

High

1286524

SRS12
Serine/arginine-rich splicing factor 12

1

16

High-throughput

0.437

High

1286527

CK052
Uncharacterized protein C11orf52

1

1

High-throughput

0.437

High

1286528

VP33A
Vacuolar protein sorting-associated protein 33A

1

1

High-throughput

0.437

High

1286545

E41LA
Band 4.1-like protein 4A

1

14

High-throughput

0.437

High

1286555

XPO7
Exportin-7

1

8

High-throughput

0.437

High

1286557

GGA2
ADP-ribosylation factor-binding protein GGA2

1

3

Small-scale

0.437

High

1099717

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

0

High-throughput

0.426

High

664928

CRHBP
Corticotropin-releasing factor-binding protein

1

1

High-throughput

0.407

High

1103255

CTBP1
C-terminal-binding protein 1

1

5

High-throughput

0.407

High

1258481

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

1

High-throughput

0.407

High

1286559

PNMA2
Paraneoplastic antigen Ma2

1

9

High-throughput

0.407

High

1286565

CLC11
C-type lectin domain family 11 member A

1

4

High-throughput

0.407

High

1286519

TEX19
Testis-expressed protein 19

1

0

High-throughput

0.279

Low

1286533

PEO1
Twinkle mtDNA helicase

1

0

High-throughput

0.279

Low

1286523

DCAF4
DDB1- and CUL4-associated factor 4

1

0

High-throughput

0.249

Low

1286550

FA53C
Protein FAM53C

1

0

High-throughput

0.249

Low

1286562

PPM1H
Protein phosphatase 1H

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025