HitPredict

Interactor 1: PTN11 (P35235)
Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2)
Gene: Ptpn11

Interactor 2: GAB2 (Q9Z1S8)
GRB2-associated-binding protein 2 (GRB2-associated binder 2) (Growth factor receptor bound protein 2-associated protein 2) (PH domain-containing adaptor molecule p97)
Gene: GAB2

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	20697350
Identification Methods	pull down
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007165 - signal transduction GO:0007229 - integrin-mediated signaling pathway GO:0019904 - protein domain specific binding and 1 others more... GO:0032991 - protein-containing complex
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 593 Mm			1 665
+	Mm
		719303 PTN11_MOUSE (1-593): 0: 605: 100.00		Q3ZB59_MOUSE (1-665): 6.22e-180: 528: 99.85
+	Hs
		986059 PTN11_HUMAN (1-593): 0: 606: 99.49		GAB2_HUMAN (4-665): 1.34e-176: 520: 90.67
+	Mm
		665998 PTN6_MOUSE (6-583): 0: 544: 55.94		GAB2_MOUSE (1-665): 2.53e-180: 529: 100.00
+	Hs
		665968 PTN6_HUMAN (6-593): 0: 540: 54.79		GAB2_HUMAN (4-665): 1.34e-176: 520: 90.67
+	Hs
		985952 PTN11_HUMAN (1-593): 0: 606: 99.49		GAB1_HUMAN (5-664): 3.8e-125: 388: 35.71
+	Mm
		719319 PTN11_MOUSE (1-593): 0: 605: 100.00		GAB1_MOUSE (5-664): 7.18e-125: 387: 36.23
+	Hs
		986000 PTN11_HUMAN (1-593): 0: 606: 99.49		GAB3_HUMAN (1-656): 5.85e-93: 301: 31.55
+	Hs
		616917 PTPRB_HUMAN (135-554): 5.13e-119: 390: 27.19		GAB1_HUMAN (5-664): 3.8e-125: 388: 35.71
+	Hs
		1020092 PTPRJ_HUMAN (180-528): 2.11e-110: 361: 31.81		GAB1_HUMAN (5-664): 3.8e-125: 388: 35.71
+	Hs
		577020 PTPRA_HUMAN (33-522): 4.31e-112: 355: 25.00		GAB1_HUMAN (5-664): 3.8e-125: 388: 35.71
+	Hs
		665957 PTN6_HUMAN (6-593): 0: 540: 54.79		PKHA2_HUMAN (3-227): 2.69e-44: 166: 21.83
+	Hs
		986058 PTN11_HUMAN (1-593): 0: 606: 99.49		DAPP1_HUMAN (10-132): 2.43e-16: 81.6: 26.77
+	Hs
		441197 PTPRC_HUMAN (33-586): 1.32e-85: 292: 19.02		GAB1_HUMAN (5-664): 3.8e-125: 388: 35.71
+	Hs
		617108 PTPRG_HUMAN (33-527): 9.57e-60: 217: 16.47		GAB1_HUMAN (5-664): 3.8e-125: 388: 35.71
+	Dm
		665797 CSW_DROME (290-575): 5.35e-107: 342: 50.00		DOS_DROME (7-620): 1.69e-43: 169: 17.92