HitPredict

Interactor 1: MERL (P35240)
Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomerlin) (Schwannomin)
Gene: NF2

Interactor 2: PALS1 (Q8N3R9)
Protein PALS1 (MAGUK p55 subfamily member 5) (Membrane protein, palmitoylated 5) (Protein associated with Lin-7 1)
Gene: PALS1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.50	0.60	0.552

Property	Details
Experiments	28514442, 21481793
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0005912 - adherens junction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 595 Hs			1 675
+	Hs
		1232502 E41L5_HUMAN (2-595): 6.77e-134: 410: 18.38		PALS1_HUMAN (1-675): 0: 561: 100.00
+	Hs
		1232503 E41LA_HUMAN (19-416): 3.96e-121: 375: 24.46		PALS1_HUMAN (1-675): 0: 561: 100.00
+	Hs
		719641 MERL_HUMAN (1-595): 1.12e-172: 504: 100.00		PALS2_HUMAN (134-674): 6.92e-142: 426: 34.66
+	Hs
		719486 MERL_HUMAN (1-595): 1.12e-172: 504: 100.00		MPP2_HUMAN (122-674): 1.21e-139: 422: 32.19
+	Hs
		1232517 E41L3_HUMAN (14-484): 8.79e-113: 363: 21.04		PALS1_HUMAN (1-675): 0: 561: 100.00
+	Hs
		159150 EZRI_HUMAN (19-595): 8.21e-152: 450: 44.20		CSKP_HUMAN (9-674): 7.61e-136: 423: 25.80
+	Hs
		547030 EZRI_HUMAN (19-595): 8.21e-152: 450: 44.20		DLG1_HUMAN (7-672): 1.81e-129: 406: 21.58
+	Hs
		159272 E41L5_HUMAN (2-595): 6.77e-134: 410: 18.38		CSKP_HUMAN (9-674): 7.61e-136: 423: 25.80
+	Hs
		547033 EZRI_HUMAN (19-595): 8.21e-152: 450: 44.20		MPP3_HUMAN (116-675): 2.89e-121: 375: 32.83
+	Hs
		159142 EPB41_HUMAN (3-566): 9.71e-126: 392: 19.73		CSKP_HUMAN (9-674): 7.61e-136: 423: 25.80
+	Hs
		159273 E41LA_HUMAN (19-416): 3.96e-121: 375: 24.46		CSKP_HUMAN (9-674): 7.61e-136: 423: 25.80
+	Hs
		505627 EPB41_HUMAN (3-566): 9.71e-126: 392: 19.73		DLG1_HUMAN (7-672): 1.81e-129: 406: 21.58
+	Mm
		250719 E41L2_MOUSE (10-519): 5.29e-114: 364: 20.68		PALS2_MOUSE (134-674): 7.21e-143: 429: 34.05
+	Hs
		1021565 E41LA_HUMAN (19-416): 3.96e-121: 375: 24.46		DLG1_HUMAN (7-672): 1.81e-129: 406: 21.58
+	Hs
		663981 PTN4_HUMAN (1-515): 8.77e-124: 388: 21.09		MPP7_HUMAN (122-674): 6.17e-127: 389: 36.06
+	Mm
		1143556 E41L3_MOUSE (14-544): 5.06e-116: 368: 20.89		DLG4_MOUSE (7-671): 3.43e-130: 402: 20.84
+	Hs
		1132894 E41LA_HUMAN (19-416): 3.96e-121: 375: 24.46		MPP7_HUMAN (122-674): 6.17e-127: 389: 36.06
+	Mm
		1143533 E41LB_MOUSE (1-455): 9.3e-117: 358: 20.30		DLG4_MOUSE (7-671): 3.43e-130: 402: 20.84
+	Ce
		184973 O17905_CAEEL (1-592): 3.24e-112: 362: 14.49		LIN2_CAEEL (8-674): 4.86e-126: 398: 24.29
+	Dm
		677683 MOEH_DROME (17-595): 4.74e-153: 453: 43.79		DLG1_DROME (150-347): 5.9e-09: 61.6: 12.62