HitPredict

Interactor 1: DRD3 (P35462)
D(3) dopamine receptor (Dopamine D3 receptor)
Gene: DRD3

Interactor 2: SH3G2 (Q99962)
Endophilin-A1 (EEN-B1) (Endophilin-1) (SH3 domain protein 2A) (SH3 domain-containing GRB2-like protein 2)
Gene: SH3GL2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	25517094
Identification Methods	pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 400 Hs			1 352
+	Hs
		723749 DRD3_HUMAN (1-400): 8.17e-97: 296: 100.00		SH3G3_HUMAN (1-352): 1.25e-89: 274: 68.08
+	Hs
		723747 DRD3_HUMAN (1-400): 8.17e-97: 296: 100.00		SH3G1_HUMAN (1-352): 1.41e-84: 262: 69.57
+	Hs
		445810 ADA2A_HUMAN (1-399): 2.81e-73: 238: 29.91		SH3G2_HUMAN (1-352): 6.15e-96: 290: 100.00
+	Hs
		436885 ACM2_HUMAN (30-400): 1.3e-72: 236: 22.78		SH3G2_HUMAN (1-352): 6.15e-96: 290: 100.00
+	Mm
		897202 DRD2_MOUSE (9-400): 1.46e-73: 238: 44.50		SH3G2_MOUSE (1-352): 3.65e-95: 288: 98.86
+	Hs
		534050 ADRB3_HUMAN (43-394): 2.61e-72: 233: 31.04		SH3G2_HUMAN (1-352): 6.15e-96: 290: 100.00
+	Hs
		574792 ADA2B_HUMAN (38-399): 2.32e-69: 227: 26.76		SH3G2_HUMAN (1-352): 6.15e-96: 290: 100.00
+	Hs
		445811 ADA2A_HUMAN (1-399): 2.81e-73: 238: 29.91		SH3G3_HUMAN (1-352): 1.25e-89: 274: 68.08
+	Hs
		534051 ADRB3_HUMAN (43-394): 2.61e-72: 233: 31.04		SH3G3_HUMAN (1-352): 1.25e-89: 274: 68.08
+	Hs
		445809 ADA2A_HUMAN (1-399): 2.81e-73: 238: 29.91		SH3G1_HUMAN (1-352): 1.41e-84: 262: 69.57
+	Hs
		436884 ACM2_HUMAN (30-400): 1.3e-72: 236: 22.78		SH3G1_HUMAN (1-352): 1.41e-84: 262: 69.57
+	Hs
		436948 ACM4_HUMAN (3-400): 5.91e-61: 206: 20.64		SH3G2_HUMAN (1-352): 6.15e-96: 290: 100.00
+	Hs
		534049 ADRB3_HUMAN (43-394): 2.61e-72: 233: 31.04		SH3G1_HUMAN (1-352): 1.41e-84: 262: 69.57
+	Hs
		1307445 HRH3_HUMAN (43-399): 1.84e-59: 201: 23.96		SH3G2_HUMAN (1-352): 6.15e-96: 290: 100.00
+	Hs
		574791 ADA2B_HUMAN (38-399): 2.32e-69: 227: 26.76		SH3G1_HUMAN (1-352): 1.41e-84: 262: 69.57
+	Hs
		436949 ACM4_HUMAN (3-400): 5.91e-61: 206: 20.64		SH3G3_HUMAN (1-352): 1.25e-89: 274: 68.08
+	Hs
		436947 ACM4_HUMAN (3-400): 5.91e-61: 206: 20.64		SH3G1_HUMAN (1-352): 1.41e-84: 262: 69.57
+	Hs
		1307428 HRH3_HUMAN (43-399): 1.84e-59: 201: 23.96		SH3G1_HUMAN (1-352): 1.41e-84: 262: 69.57
+	Hs
		723735 DRD3_HUMAN (1-400): 8.17e-97: 296: 100.00		GRB2_HUMAN (295-351): 1.51e-12: 67.8: 43.10
+	Mm
		897204 DRD2_MOUSE (9-400): 1.46e-73: 238: 44.50		SH3K1_MOUSE (280-347): 3.72e-10: 63.2: 44.00