HitPredict

Interactor 1: IRS1 (P35568)
Insulin receptor substrate 1 (IRS-1)
Gene: IRS1

Interactor 2: PTN11 (Q06124)
Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1D) (PTP-1D) (Protein-tyrosine phosphatase 2C) (PTP-2C) (SH-PTP2) (SHP-2) (Shp2) (SH-PTP3)
Gene: PTPN11

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.87 0.60 0.725

The method score is based on:

Property Details
Experiments 22974441, 11781100, 9535915, 8505282, 9756938, 7513703
Identification Methods unspecified method, pull down, affinity chromatography technology, enzymatic study, surface plasmon resonance
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0001784 - phosphotyrosine residue binding
GO:0005158 - insulin receptor binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
and 7 others

more...
Homologous interactions 10

Homologous interactions

Color coding for hit scores

1 1242
Hs

1 593
+ Rn
+ Hs
+ Hs
+ Rn
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+ Hs
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024