HitPredict

Interactor 1: ACRB (P31224)
Multidrug efflux pump subunit AcrB (AcrAB-TolC multidrug efflux pump subunit AcrB) (Acridine resistance protein B)
Gene: ACRB

Interactor 2: ACRB (P31224)
Multidrug efflux pump subunit AcrB (AcrAB-TolC multidrug efflux pump subunit AcrB) (Acridine resistance protein B)
Gene: ACRB

Species: Escherichia coli K-12

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.92 1.00 0.960

The method score is based on:

Property Details
Experiments 25451234, 16079137, 16915237, 18223659, 22121023, 22451937, 23812586
Identification Methods molecular sieving, electron microscopy, blue native page, x-ray crystallography, comigration in sds page
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains ACR_tran~ACR_tran
Common GO terms GO:0005886 - plasma membrane
GO:0009410 - response to xenobiotic stimulus
GO:0009636 - response to toxic substance
GO:0015125 - bile acid transmembrane transporter activity
GO:0015562 - efflux transmembrane transporter activity
and 13 others

more...
Homologous interactions 10

Homologous interactions

Color coding for hit scores

1 1049
Ec

1 1049
+ Pa
+ Ec
+ Ec
+ Ec
+ Ec
+ Bs
+ Ec
+ Bs
+ Hs
+ Dm

Service provided by Combinatics, Japan

Last updated: 11Aug2025