HitPredict

Interactor 1: FUS (P35637)
RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein)
Gene: FUS

Interactor 2: MAX (P61244)
Protein max (Class D basic helix-loop-helix protein 4) (bHLHd4) (Myc-associated factor X)
Gene: MAX

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.60	0.561

Property	Details
Experiments	20195357
Identification Methods	pull down, display technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 526 Hs			1 160
+	Hs
		347491 RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10		MYC_HUMAN (14-105): 1.81e-21: 91.5: 34.74
+	Hs
		379677 RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10		MYCN_HUMAN (7-101): 2.1e-21: 91.1: 33.67
+	Hs
		726850 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		USF2_HUMAN (16-115): 1.18e-24: 99.1: 29.91
+	Hs
		346094 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		MYC_HUMAN (14-105): 1.81e-21: 91.5: 34.74
+	Hs
		379073 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		MYCN_HUMAN (7-101): 2.1e-21: 91.1: 33.67
+	Dm
		1099595 CAZ_DROME (175-481): 5.46e-34: 134: 38.91		Q9W4Q7_DROME (13-108): 2.97e-23: 96.9: 25.51
+	Mm
		1142805 EWS_MOUSE (3-451): 2.8e-30: 127: 35.56		SRBP1_MOUSE (9-134): 2.94e-25: 102: 19.38
+	Hs
		607809 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		USF1_HUMAN (10-115): 4.62e-23: 94.1: 30.97
+	Hs
		346559 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		MYC_HUMAN (14-105): 1.81e-21: 91.5: 34.74
+	Hs
		379305 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		MYCN_HUMAN (7-101): 2.1e-21: 91.1: 33.67
+	Hs
		348237 PPIE_HUMAN (280-514): 1.23e-31: 125: 19.46		MYC_HUMAN (14-105): 1.81e-21: 91.5: 34.74
+	Hs
		380019 PPIE_HUMAN (280-514): 1.23e-31: 125: 19.46		MYCN_HUMAN (7-101): 2.1e-21: 91.1: 33.67
+	Hs
		967494 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		MLX_HUMAN (3-121): 1.05e-19: 84.9: 23.02
+	Hs
		348368 RBM8A_HUMAN (219-366): 3.35e-27: 109: 26.35		MYC_HUMAN (14-105): 1.81e-21: 91.5: 34.74
+	Hs
		380076 RBM8A_HUMAN (219-366): 3.35e-27: 109: 26.35		MYCN_HUMAN (7-101): 2.1e-21: 91.1: 33.67
+	Hs
		346697 PABP4_HUMAN (280-379): 4.96e-13: 73.5: 22.00		MYC_HUMAN (14-105): 1.81e-21: 91.5: 34.74
+	Hs
		379365 PABP4_HUMAN (280-379): 4.96e-13: 73.5: 22.00		MYCN_HUMAN (7-101): 2.1e-21: 91.1: 33.67
+	Hs
		345797 PABP1_HUMAN (184-382): 3.08e-12: 71.2: 12.44		MYC_HUMAN (14-105): 1.81e-21: 91.5: 34.74
+	Hs
		378957 PABP1_HUMAN (184-382): 3.08e-12: 71.2: 12.44		MYCN_HUMAN (7-101): 2.1e-21: 91.1: 33.67
+	Hs
		346316 SC24C_HUMAN (1-262): 5.36e-11: 67.4: 14.34		MYC_HUMAN (14-105): 1.81e-21: 91.5: 34.74