HitPredict

Interactor 1: FUS (P35637)
RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein)
Gene: FUS

Interactor 2: CSTF1 (Q05048)
Cleavage stimulation factor subunit 1 (CF-1 50 kDa subunit) (Cleavage stimulation factor 50 kDa subunit) (CSTF 50 kDa subunit) (CstF-50)
Gene: CSTF1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005654 - nucleoplasm
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 526 Hs			1 431
+	Hs
		903407 RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10		WDR5_HUMAN (2-289): 2.37e-58: 196: 17.75
+	Hs
		726698 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		WDR5_HUMAN (2-289): 2.37e-58: 196: 17.75
+	Hs
		903140 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		WDR5_HUMAN (2-289): 2.37e-58: 196: 17.75
+	Hs
		967471 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		NLE1_HUMAN (247-429): 1.25e-46: 169: 18.48
+	Hs
		1103006 RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10		SMU1_HUMAN (253-429): 5.21e-28: 117: 19.02
+	Hs
		1271160 RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10		SNR40_HUMAN (3-195): 1.23e-28: 117: 19.50
+	Hs
		903196 PABP4_HUMAN (280-379): 4.96e-13: 73.5: 22.00		WDR5_HUMAN (2-289): 2.37e-58: 196: 17.75
+	Hs
		726858 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		SMU1_HUMAN (253-429): 5.21e-28: 117: 19.02
+	Hs
		726980 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		SNR40_HUMAN (3-195): 1.23e-28: 117: 19.50
+	Hs
		516438 PABP1_HUMAN (184-382): 3.08e-12: 71.2: 12.44		WDR5_HUMAN (2-289): 2.37e-58: 196: 17.75
+	Hs
		1271156 RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10		FBXW7_HUMAN (2-196): 3e-19: 92.1: 12.75
+	Hs
		967341 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		SNR40_HUMAN (3-195): 1.23e-28: 117: 19.50
+	Sc
		376655 PABP_YEAST (263-381): 1.57e-10: 65.5: 18.49		PWP2_YEAST (65-426): 9.96e-49: 179: 9.98
+	Hs
		1288389 PPIE_HUMAN (280-514): 1.23e-31: 125: 19.46		SNR40_HUMAN (3-195): 1.23e-28: 117: 19.50
+	Hs
		1271214 RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10		PRP19_HUMAN (136-335): 3.89e-14: 76.3: 24.50
+	Hs
		727094 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		PRP19_HUMAN (136-335): 3.89e-14: 76.3: 24.50
+	Hs
		1074803 RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10		TAF5_HUMAN (119-338): 1.63e-09: 62: 24.24
+	Hs
		212170 HTSF1_HUMAN (267-372): 6.19e-23: 104: 21.30		SNR40_HUMAN (3-195): 1.23e-28: 117: 19.50
+	Hs
		1357322 PPIE_HUMAN (280-514): 1.23e-31: 125: 19.46		PRP19_HUMAN (136-335): 3.89e-14: 76.3: 24.50