HitPredict

Interactor 1: FUS (P35637)
RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein)
Gene: FUS

Interactor 2: PABP4 (Q13310)
Polyadenylate-binding protein 4 (PABP-4) (Poly(A)-binding protein 4) (Activated-platelet protein 1) (APP-1) (Inducible poly(A)-binding protein) (iPABP)
Gene: PABPC4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.737

Property	Details
Experiments	29884807, 27460707
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0003730 - mRNA 3'-UTR binding GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 526 Hs			1 644
+	Hs
		1031411 RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10		PABP4_HUMAN (1-644): 0: 585: 100.00
+	Hs
		516620 RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10		PABP1_HUMAN (1-644): 0: 542: 74.54
+	Hs
		1031507 RBM8A_HUMAN (219-366): 3.35e-27: 109: 26.35		PABP4_HUMAN (1-644): 0: 585: 100.00
+	Hs
		516383 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		PABP1_HUMAN (1-644): 0: 542: 74.54
+	Hs
		516744 PPIE_HUMAN (280-514): 1.23e-31: 125: 19.46		PABP1_HUMAN (1-644): 0: 542: 74.54
+	Hs
		516768 RBM8A_HUMAN (219-366): 3.35e-27: 109: 26.35		PABP1_HUMAN (1-644): 0: 542: 74.54
+	Hs
		516495 PABP4_HUMAN (280-379): 4.96e-13: 73.5: 22.00		PABP1_HUMAN (1-644): 0: 542: 74.54
+	Hs
		516339 PABP1_HUMAN (184-382): 3.08e-12: 71.2: 12.44		PABP1_HUMAN (1-644): 0: 542: 74.54
+	Hs
		516689 PABP1_HUMAN (184-382): 3.08e-12: 71.2: 12.44		PABP3_HUMAN (1-644): 7.04e-175: 513: 68.98
+	Hs
		967171 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		ELAV3_HUMAN (3-272): 2.13e-40: 153: 19.15
+	Hs
		582097 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		NUCL_HUMAN (2-89): 1.4e-20: 98.4: 31.82
+	Hs
		582561 PPIE_HUMAN (280-514): 1.23e-31: 125: 19.46		NUCL_HUMAN (2-89): 1.4e-20: 98.4: 31.82
+	Hs
		474021 PABP4_HUMAN (280-379): 4.96e-13: 73.5: 22.00		PAB4L_HUMAN (192-380): 4.58e-38: 146: 31.05
+	Hs
		582580 RBM8A_HUMAN (219-366): 3.35e-27: 109: 26.35		NUCL_HUMAN (2-89): 1.4e-20: 98.4: 31.82
+	Mm
		857328 EWS_MOUSE (3-451): 2.8e-30: 127: 35.56		TIA1_MOUSE (4-86): 1.26e-12: 72: 30.12
+	Hs
		680441 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		TIA1_HUMAN (4-109): 7.62e-12: 69.5: 24.53
+	Hs
		516355 PABP1_HUMAN (184-382): 3.08e-12: 71.2: 12.44		NUCL_HUMAN (2-89): 1.4e-20: 98.4: 31.82
+	Hs
		1119141 PAP1L_HUMAN (182-382): 2.39e-13: 74.7: 13.43		PABP5_HUMAN (4-93): 1.22e-15: 81: 23.33
+	Hs
		516635 PABP1_HUMAN (184-382): 3.08e-12: 71.2: 12.44		PABP5_HUMAN (4-93): 1.22e-15: 81: 23.33