HitPredict

Interactor 1: SOX6 (P35712)
Transcription factor SOX-6
Gene: SOX6

Interactor 2: CTBP2 (P56545)
C-terminal-binding protein 2 (CtBP2)
Gene: CTBP2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.620

Property	Details
Experiments	11504872, 35140242
Identification Methods	affinity chromatography technology, two hybrid, proximity labelling technology
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 828 Hs			1 445
+	Hs
		727862 SOX6_HUMAN (1-828): 0: 640: 100.00		CTBP1_HUMAN (20-445): 0: 520: 80.99
+	Hs
		881308 TF7L2_HUMAN (327-801): 6.75e-37: 149: 12.07		CTBP2_HUMAN (1-445): 0: 604: 100.00
+	Hs
		881305 TF7L1_HUMAN (415-783): 1.27e-35: 145: 12.93		CTBP2_HUMAN (1-445): 0: 604: 100.00
+	Hs
		881337 SOX13_HUMAN (96-382): 1.45e-35: 145: 36.33		CTBP2_HUMAN (1-445): 0: 604: 100.00
+	Hs
		817843 SOX2_HUMAN (587-707): 3.88e-37: 144: 38.02		CTBP2_HUMAN (1-445): 0: 604: 100.00
+	Mm
		1142013 Q60I23_MOUSE (582-707): 1.71e-36: 142: 38.10		Q91YZ2_MOUSE (26-445): 0: 558: 99.52
+	Hs
		1032565 CIC_HUMAN (323-827): 1.48e-39: 161: 15.33		CTBP1_HUMAN (20-445): 0: 520: 80.99
+	Hs
		996651 SSRP1_HUMAN (257-792): 1.33e-37: 152: 12.45		CTBP1_HUMAN (20-445): 0: 520: 80.99
+	Hs
		1032636 TF7L2_HUMAN (327-801): 6.75e-37: 149: 12.07		CTBP1_HUMAN (20-445): 0: 520: 80.99
+	Hs
		818014 SOX2_HUMAN (587-707): 3.88e-37: 144: 38.02		CTBP1_HUMAN (20-445): 0: 520: 80.99
+	Dm
		220645 Q59DN5_DROME (277-805): 1.99e-50: 189: 24.33		CTBP_DROME (10-367): 1.28e-140: 412: 72.35
+	Hs
		197254 SOX2_HUMAN (587-707): 3.88e-37: 144: 38.02		SERA_HUMAN (35-410): 8.39e-125: 374: 27.32