HitPredict

Interactor 1: K22E (P35908)
Keratin, type II cytoskeletal 2 epidermal (Cytokeratin-2e) (CK-2e) (Epithelial keratin-2e) (Keratin-2 epidermis) (Keratin-2e) (K2e) (Type-II keratin Kb2)
Gene: KRT2

Interactor 2: CYLD (Q9NQC7)
Ubiquitin carboxyl-terminal hydrolase CYLD (EC 3.4.19.12) (Deubiquitinating enzyme CYLD) (Ubiquitin thioesterase CYLD) (Ubiquitin-specific-processing protease CYLD)
Gene: CYLD

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	27591049
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 639 Hs			1 956
+	Hs
		409246 K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33		CYLD_HUMAN (1-956): 0: 1872: 100.00
+	Hs
		444557 K2C7_HUMAN (86-542): 4.82e-131: 395: 52.62		CYLD_HUMAN (1-956): 0: 1872: 100.00
+	Hs
		380696 K2C1_HUMAN (143-509): 1.63e-112: 353: 71.94		CYLD_HUMAN (1-956): 0: 1872: 100.00
+	Hs
		1343331 KRT84_HUMAN (5-589): 2.17e-100: 320: 44.20		CYLD_HUMAN (1-956): 0: 1872: 100.00
+	Hs
		531636 K2C5_HUMAN (1-494): 7.49e-82: 271: 61.48		CYLD_HUMAN (1-956): 0: 1872: 100.00
+	Hs
		380523 K2C6B_HUMAN (5-510): 8.35e-82: 270: 61.22		CYLD_HUMAN (1-956): 0: 1872: 100.00
+	Hs
		1110348 K2C71_HUMAN (1-570): 6.15e-82: 269: 51.23		CYLD_HUMAN (1-956): 0: 1872: 100.00
+	Hs
		1192468 K2C1B_HUMAN (58-509): 2.24e-79: 264: 61.95		CYLD_HUMAN (1-956): 0: 1872: 100.00
+	Hs
		359537 K2C6A_HUMAN (5-510): 8.33e-78: 259: 61.22		CYLD_HUMAN (1-956): 0: 1872: 100.00
+	Hs
		1062069 K2C72_HUMAN (87-494): 7.09e-77: 255: 61.28		CYLD_HUMAN (1-956): 0: 1872: 100.00