HitPredict

Interactor 1: VGFR3 (P35916)
Vascular endothelial growth factor receptor 3 (VEGFR-3) (EC 2.7.10.1) (Fms-like tyrosine kinase 4) (FLT-4) (Tyrosine-protein kinase receptor FLT4)
Gene: FLT4

Interactor 2: VEGFC (P49767)
Vascular endothelial growth factor C (VEGF-C) (Flt4 ligand) (Flt4-L) (Vascular endothelial growth factor-related protein) (VRP)
Gene: VEGFC

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.60 1.00 0.776

The method score is based on:

Property Details
Experiments 8700872, 21130043
Identification Methods affinity chromatography technology, coimmunoprecipitation, solid phase assay
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains PDGF~ig
Common GO terms GO:0001934 - positive regulation of protein phosphorylation
GO:0001938 - positive regulation of endothelial cell proliferation
GO:0002040 - sprouting angiogenesis
GO:0005576 - extracellular region
GO:0008284 - positive regulation of cell population proliferation
and 2 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 1363
Hs

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Last updated: 15 Jul 2024