HitPredict

Interactor 1: ROA1 (P09651)
Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) (Helix-destabilizing protein) (Single-strand RNA-binding protein) (hnRNP core protein A1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed]
Gene: HNRNPA1

Interactor 2: PABP4 (Q13310)
Polyadenylate-binding protein 4 (PABP-4) (Poly(A)-binding protein 4) (Activated-platelet protein 1) (APP-1) (Inducible poly(A)-binding protein) (iPABP)
Gene: PABPC4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	26186194, 17643375
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:1990904 - ribonucleoprotein complex
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 372 Hs			1 644
+	Hs
		172092 HNRDL_HUMAN (2-282): 5.24e-72: 232: 33.56		PABP4_HUMAN (1-644): 0: 578: 100.00
+	Hs
		172001 HNRDL_HUMAN (2-282): 5.24e-72: 232: 33.56		PABP1_HUMAN (1-644): 0: 533: 74.54
+	Hs
		484876 ROA1_HUMAN (1-372): 6.83e-64: 210: 100.00		PABP1_HUMAN (1-644): 0: 533: 74.54
+	Hs
		550189 ROA3_HUMAN (7-202): 1.05e-56: 191: 85.71		PABP1_HUMAN (1-644): 0: 533: 74.54
+	Hs
		550120 ROA2_HUMAN (1-320): 2.13e-56: 189: 58.44		PABP1_HUMAN (1-644): 0: 533: 74.54
+	Hs
		1102095 PABP3_HUMAN (6-193): 7.32e-37: 142: 17.90		PABP4_HUMAN (1-644): 0: 578: 100.00
+	Hs
		550464 PABP3_HUMAN (6-193): 7.32e-37: 142: 17.90		PABP1_HUMAN (1-644): 0: 533: 74.54
+	Hs
		550436 ROAA_HUMAN (6-184): 1.25e-35: 134: 39.44		PABP1_HUMAN (1-644): 0: 533: 74.54
+	Hs
		550278 HNRPD_HUMAN (2-99): 4.16e-18: 86.4: 24.00		PABP1_HUMAN (1-644): 0: 533: 74.54
+	Hs
		1197178 PABP3_HUMAN (6-193): 7.32e-37: 142: 17.90		PAP1L_HUMAN (1-636): 4.05e-161: 477: 63.84
+	Hs
		550262 PABP4_HUMAN (102-193): 4.58e-15: 78.7: 15.05		PABP1_HUMAN (1-644): 0: 533: 74.54
+	Dm
		636388 SQD_DROME (3-187): 1.1e-52: 179: 32.43		PABP_DROME (2-304): 4.28e-60: 213: 27.66
+	Hs
		484908 ROA1_HUMAN (1-372): 6.83e-64: 210: 100.00		NUCL_HUMAN (2-89): 3.35e-20: 97.2: 31.82
+	Hs
		485322 ROA1_HUMAN (1-372): 6.83e-64: 210: 100.00		PABP5_HUMAN (4-93): 2.56e-15: 80.3: 23.33
+	Hs
		909657 ROA3_HUMAN (7-202): 1.05e-56: 191: 85.71		PABP5_HUMAN (4-93): 2.56e-15: 80.3: 23.33
+	Hs
		726763 HNRPD_HUMAN (2-99): 4.16e-18: 86.4: 24.00		TIA1_HUMAN (3-172): 3.37e-35: 139: 28.42
+	Hs
		620361 HNRPD_HUMAN (2-99): 4.16e-18: 86.4: 24.00		NUCL_HUMAN (2-89): 3.35e-20: 97.2: 31.82
+	Hs
		1102056 PABP4_HUMAN (102-193): 4.58e-15: 78.7: 15.05		PABP5_HUMAN (4-93): 2.56e-15: 80.3: 23.33
+	Hs
		506129 PABP4_HUMAN (102-193): 4.58e-15: 78.7: 15.05		PAB4L_HUMAN (290-381): 2.81e-12: 70.6: 24.47