HitPredict

Interactor 1: VGFR2 (P35968)
Vascular endothelial growth factor receptor 2 (VEGFR-2) (EC 2.7.10.1) (Fetal liver kinase 1) (FLK-1) (Kinase insert domain receptor) (KDR) (Protein-tyrosine kinase receptor flk-1) (CD antigen CD309)
Gene: KDR

Interactor 2: SHB (Q15464)
SH2 domain-containing adapter protein B
Gene: SHB

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	15026417
Identification Methods	affinity chromatography technology, coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0001525 - angiogenesis GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1356 Hs			1 509
+	Hs
		666023 VGFR2_HUMAN (1-1356): 0: 1028: 100.00		SHC1_HUMAN (105-508): 5.28e-65: 222: 17.27
+	Hs
		729640 VGFR2_HUMAN (1-1356): 0: 1028: 100.00		SHC2_HUMAN (106-507): 6.45e-63: 217: 15.07
+	Hs
		522825 VGFR2_HUMAN (1-1356): 0: 1028: 100.00		SRC_HUMAN (264-488): 5.65e-61: 211: 18.57
+	Hs
		557625 VGFR2_HUMAN (1-1356): 0: 1028: 100.00		NCK1_HUMAN (157-504): 3.1e-55: 191: 14.25
+	Hs
		412060 VGFR2_HUMAN (1-1356): 0: 1028: 100.00		FYN_HUMAN (280-506): 1.72e-53: 190: 15.32
+	Hs
		729636 VGFR2_HUMAN (1-1356): 0: 1028: 100.00		GRB2_HUMAN (349-507): 2.61e-46: 162: 15.63
+	Dm
		112231 M9MRE1_DROME (31-1354): 0: 608: 21.17		SRC42_DROME (299-504): 4.56e-62: 213: 16.20
+	Dm
		112209 M9MRE1_DROME (31-1354): 0: 608: 21.17		ABL_DROME (332-507): 3.08e-50: 187: 26.55
+	Dm
		112214 M9MRE1_DROME (31-1354): 0: 608: 21.17		GRAP_DROME (349-509): 1.63e-46: 163: 20.50
+	Dm
		112212 M9MRE1_DROME (31-1354): 0: 608: 21.17		CSW_DROME (408-490): 1.18e-17: 88.5: 32.14
+	Mm
		643644 PGFRA_MOUSE (11-545): 2.38e-56: 215: 19.35		SHB_MOUSE (1-509): 3.14e-117: 356: 89.98
+	Mm
		403421 RET_MOUSE (809-1201): 1.5e-77: 281: 41.01		SRC_MOUSE (264-488): 1.12e-63: 218: 18.64
+	Hs
		145969 PGFRB_HUMAN (33-555): 3.92e-53: 205: 18.45		SH2B2_HUMAN (56-507): 1.2e-64: 223: 13.94
+	Hs
		208979 PGFRB_HUMAN (33-555): 3.92e-53: 205: 18.45		NCK2_HUMAN (157-505): 7.36e-63: 211: 17.45
+	Hs
		452338 PGFRB_HUMAN (33-555): 3.92e-53: 205: 18.45		SRC_HUMAN (264-488): 5.65e-61: 211: 18.57
+	Hs
		433221 PGFRB_HUMAN (33-555): 3.92e-53: 205: 18.45		YES_HUMAN (252-488): 8.79e-54: 191: 17.21
+	Hs
		411953 PGFRB_HUMAN (33-555): 3.92e-53: 205: 18.45		FYN_HUMAN (280-506): 1.72e-53: 190: 15.32
+	Hs
		557172 PGFRA_HUMAN (11-545): 1.02e-53: 207: 19.71		SHF_HUMAN (157-509): 1.21e-52: 185: 40.43
+	Hs
		557088 PGFRA_HUMAN (11-545): 1.02e-53: 207: 19.71		GRB2_HUMAN (349-507): 2.61e-46: 162: 15.63
+	Hs
		337317 PGFRB_HUMAN (33-555): 3.92e-53: 205: 18.45		ABL1_HUMAN (354-507): 1.09e-35: 143: 24.03