Protein: MTREX
Exosome RNA helicase MTR4 (EC 3.6.4.13) (ATP-dependent RNA helicase DOB1) (ATP-dependent RNA helicase SKIV2L2) (Superkiller viralicidic activity 2-like 2) (TRAMP-like complex helicase)

Gene: MTREX
Organism: Homo sapiens
Interactions: 204
UniProt ID: P42285

Gene Ontology (top 5):
GO:0000398 - mRNA splicing, via spliceosome
GO:0000460 - maturation of 5.8S rRNA
GO:0003723 - RNA binding
GO:0003724 - RNA helicase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

838795

EXOS3
Exosome complex component RRP40

4

4

High-throughput

0.903

High

838716

EXOS2
Exosome complex component RRP4

3

6

Small-scale

0.839

High

838813

EXOS1
Exosome complex component CSL4

2

9

High-throughput

0.789

High

838706

NCBP1
Nuclear cap-binding protein subunit 1

2

6

High-throughput

0.776

High

838700

EXOSX
Exosome complex component 10

2

5

High-throughput

0.754

High

838815

RBM7
RNA-binding protein 7

6

17

High-throughput

0.736

High

838723

EXOS7
Exosome complex component RRP42

4

15

High-throughput

0.694

High

244652

ZC3H1
Zinc finger C3H1 domain-containing protein

1

4

High-throughput

0.691

High

838704

DHX9
ATP-dependent RNA helicase A

1

19

High-throughput

0.691

High

838797

DDX21
Nucleolar RNA helicase 2

1

18

High-throughput

0.691

High

371386

MYC
Myc proto-oncogene protein

4

20

High-throughput

0.676

High

838794

EXOS5
Exosome complex component RRP46

3

19

High-throughput

0.675

High

729659

1433B
14-3-3 protein beta/alpha

3

11

High-throughput

0.667

High

838792

EXOS4
Exosome complex component RRP41

3

17

Small-scale

0.667

High

838775

MPH6
M-phase phosphoprotein 6

4

0

Small-scale

0.658

High

838732

IF16
Gamma-interferon-inducible protein 16

3

13

High-throughput

0.656

High

838741

ZCHC8
Zinc finger CCHC domain-containing protein 8

4

0

Small-scale

0.651

High

717710

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

2

5

High-throughput

0.635

High

838788

RENT2
Regulator of nonsense transcripts 2

1

0

High-throughput

0.622

High

838694

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

2

5

High-throughput

0.621

High

838737

2ABD
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

3

5

High-throughput

0.619

High

285130

EED
Polycomb protein EED

1

20

High-throughput

0.618

High

315233

RECQ4
ATP-dependent DNA helicase Q4

1

19

High-throughput

0.618

High

731045

STIP1
Stress-induced-phosphoprotein 1

1

9

High-throughput

0.618

High

838675

RECQ1
ATP-dependent DNA helicase Q1

1

17

High-throughput

0.618

High

838708

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

16

High-throughput

0.618

High

838719

DHX8
ATP-dependent RNA helicase DHX8

1

18

High-throughput

0.618

High

838721

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

16

High-throughput

0.618

High

838770

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

20

High-throughput

0.618

High

838778

GRWD1
Glutamate-rich WD repeat-containing protein 1

1

16

High-throughput

0.618

High

838799

RNC
Ribonuclease 3

1

11

High-throughput

0.618

High

690807

1433T
14-3-3 protein theta

2

11

High-throughput

0.611

High

838686

RBM11
Splicing regulator RBM11

2

19

High-throughput

0.611

High

838687

1433G
14-3-3 protein gamma

2

11

High-throughput

0.611

High

838693

1433Z
14-3-3 protein zeta/delta

2

11

High-throughput

0.611

High

838717

C1D
Nuclear nucleic acid-binding protein C1D

2

0

High-throughput

0.602

High

830280

CCNF
Cyclin-F

2

7

High-throughput

0.601

High

838683

NCBP2
Nuclear cap-binding protein subunit 2

2

17

High-throughput

0.601

High

838733

EXOS6
Exosome complex component MTR3

2

20

High-throughput

0.586

High

128829

MEN1
Menin

2

5

High-throughput

0.584

High

413347

P53
Cellular tumor antigen p53

2

5

High-throughput

0.584

High

588108

RFA2
Replication protein A 32 kDa subunit

2

13

High-throughput

0.584

High

694825

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

10

High-throughput

0.584

High

767601

RFA3
Replication protein A 14 kDa subunit

2

8

High-throughput

0.584

High

838712

TIF1B
Transcription intermediary factor 1-beta

2

15

High-throughput

0.584

High

838715

CUL3
Cullin-3

2

19

High-throughput

0.584

High

838764

DI3L1
DIS3-like exonuclease 1

2

8

Small-scale

0.584

High

838769

EXOS8
Exosome complex component RRP43

2

15

High-throughput

0.584

High

838802

MCM9
DNA helicase MCM9

2

8

Small-scale

0.584

High

838697

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

2

5

High-throughput

0.580

High

395639

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

774899

FUS
RNA-binding protein FUS

2

20

High-throughput

0.571

High

838738

A16L1
Autophagy-related protein 16-1

1

19

High-throughput

0.553

High

838744

TRI67
Tripartite motif-containing protein 67

1

12

High-throughput

0.553

High

838756

MIB1
E3 ubiquitin-protein ligase MIB1

1

3

High-throughput

0.553

High

838808

HECD1
E3 ubiquitin-protein ligase HECTD1

1

20

High-throughput

0.553

High

166126

AIM2
Interferon-inducible protein AIM2

1

13

High-throughput

0.536

High

251719

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

1

4

High-throughput

0.536

High

431014

LA
Lupus La protein

1

17

High-throughput

0.536

High

461241

HS90A
Heat shock protein HSP 90-alpha

1

12

High-throughput

0.536

High

477943

SNRPA
U1 small nuclear ribonucleoprotein A

1

20

High-throughput

0.536

High

541875

TOP1
DNA topoisomerase 1

1

7

High-throughput

0.536

High

576307

HNRPL
Heterogeneous nuclear ribonucleoprotein L

1

9

High-throughput

0.536

High

791154

SYUA
Alpha-synuclein

1

5

High-throughput

0.536

High

833077

MNDA
Myeloid cell nuclear differentiation antigen

1

13

High-throughput

0.536

High

838674

KSYK
Tyrosine-protein kinase SYK

1

10

High-throughput

0.536

High

838676

RL5
Large ribosomal subunit protein uL18

1

2

High-throughput

0.536

High

838677

SOX2
Transcription factor SOX-2

1

19

High-throughput

0.536

High

838680

CLK2
Dual specificity protein kinase CLK2

1

11

High-throughput

0.536

High

838689

1433E
14-3-3 protein epsilon

1

2

High-throughput

0.536

High

838696

CSK21
Casein kinase II subunit alpha

1

11

High-throughput

0.536

High

838731

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

10

High-throughput

0.536

High

838752

ZCH18
Zinc finger CCCH domain-containing protein 18

1

8

High-throughput

0.536

High

838762

BD1L1
Biorientation of chromosomes in cell division protein 1-like 1

1

2

High-throughput

0.536

High

838774

CDC5L
Cell division cycle 5-like protein

1

10

High-throughput

0.536

High

838816

OAS3
2'-5'-oligoadenylate synthase 3

1

1

High-throughput

0.536

High

271961

OBSL1
Obscurin-like protein 1

2

6

High-throughput

0.533

High

838751

LYRIC
Protein LYRIC

1

0

High-throughput

0.513

High

838783

COMD4
COMM domain-containing protein 4

1

0

High-throughput

0.513

High

838768

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

11

High-throughput

0.501

High

838681

RB27A
Ras-related protein Rab-27A

1

1

High-throughput

0.489

High

838702

1433F
14-3-3 protein eta

1

11

High-throughput

0.489

High

352751

F107A
Actin-associated protein FAM107A

1

1

Small-scale

0.481

High

838758

XRN1
5'-3' exoribonuclease 1

1

5

High-throughput

0.481

High

131792

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

13

High-throughput

0.479

High

134589

SAP18
Histone deacetylase complex subunit SAP18

1

3

High-throughput

0.479

High

157051

CTRO
Citron Rho-interacting kinase

1

10

High-throughput

0.479

High

172540

XPO1
Exportin-1

1

9

High-throughput

0.479

High

238425

RAD21
Double-strand-break repair protein rad21 homolog

1

2

High-throughput

0.479

High

240983

PRKN
E3 ubiquitin-protein ligase parkin

1

15

High-throughput

0.479

High

247722

NUPR1
Nuclear protein 1

1

6

High-throughput

0.479

High

252024

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

2

High-throughput

0.479

High

256792

H2B1K
Histone H2B type 1-K

1

11

High-throughput

0.479

High

259574

BRD4
Bromodomain-containing protein 4

1

20

High-throughput

0.479

High

319489

UFL1
E3 UFM1-protein ligase 1

1

5

High-throughput

0.479

High

355447

NSD2
Histone-lysine N-methyltransferase NSD2

1

12

Small-scale

0.479

High

405871

MYCN
N-myc proto-oncogene protein

1

20

High-throughput

0.479

High

411519

NTRK1
High affinity nerve growth factor receptor

1

11

High-throughput

0.479

High

446733

NPM
Nucleophosmin

1

9

High-throughput

0.479

High

472503

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

20

High-throughput

0.479

High

487051

PARP1
Poly [ADP-ribose] polymerase 1

1

10

High-throughput

0.479

High

519812

ANDR
Androgen receptor

1

20

High-throughput

0.479

High

606373

CEBPB
CCAAT/enhancer-binding protein beta

1

9

High-throughput

0.479

High

620184

NUCL
Nucleolin

1

15

High-throughput

0.479

High

657507

GCSP
Glycine dehydrogenase

1

3

High-throughput

0.479

High

730428

1433S
14-3-3 protein sigma

1

11

High-throughput

0.479

High

761960

GRK5
G protein-coupled receptor kinase 5

1

7

High-throughput

0.479

High

765213

BMI1
Polycomb complex protein BMI-1

1

11

High-throughput

0.479

High

786426

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

4

High-throughput

0.479

High

838673

MATR3
Matrin-3

1

7

High-throughput

0.479

High

838678

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

12

High-throughput

0.479

High

838682

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

8

High-throughput

0.479

High

838685

FOXA1
Hepatocyte nuclear factor 3-alpha

1

19

High-throughput

0.479

High

838688

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

7

High-throughput

0.479

High

838690

H4
Histone H4

1

7

High-throughput

0.479

High

838691

H2B1C
Histone H2B type 1-C/E/F/G/I

1

11

High-throughput

0.479

High

838692

RL31
Large ribosomal subunit protein eL31

1

6

High-throughput

0.479

High

838695

CSK2B
Casein kinase II subunit beta

1

3

High-throughput

0.479

High

838698

VIGLN
Vigilin

1

13

High-throughput

0.479

High

838701

MECOM
Histone-lysine N-methyltransferase MECOM

1

5

High-throughput

0.479

High

838703

EXOS9
Exosome complex component RRP45

1

16

High-throughput

0.479

High

838707

EP300
Histone acetyltransferase p300

1

20

High-throughput

0.479

High

838710

NFX1
Transcriptional repressor NF-X1

1

11

High-throughput

0.479

High

838711

TADBP
TAR DNA-binding protein 43

1

16

High-throughput

0.479

High

838713

BIRC3
Baculoviral IAP repeat-containing protein 3

1

6

High-throughput

0.479

High

838714

CUL1
Cullin-1

1

19

High-throughput

0.479

High

838718

RBM39
RNA-binding protein 39

1

13

High-throughput

0.479

High

838724

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

11

High-throughput

0.479

High

838725

KIF14
Kinesin-like protein KIF14

1

6

High-throughput

0.479

High

838726

RNPS1
RNA-binding protein with serine-rich domain 1

1

20

High-throughput

0.479

High

838727

SF3A1
Splicing factor 3A subunit 1

1

5

High-throughput

0.479

High

838730

E2F4
Transcription factor E2F4

1

3

High-throughput

0.479

High

838735

RC3H1
Roquin-1

1

7

High-throughput

0.479

High

838740

ZN746
Zinc finger protein 746

1

3

High-throughput

0.479

High

838743

GGYF2
GRB10-interacting GYF protein 2

1

2

High-throughput

0.479

High

838745

MOB3C
MOB kinase activator 3C

1

2

High-throughput

0.479

High

838746

MEPCE
7SK snRNA methylphosphate capping enzyme

1

4

High-throughput

0.479

High

838747

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

7

High-throughput

0.479

High

838748

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

15

High-throughput

0.479

High

838749

UBP37
Ubiquitin carboxyl-terminal hydrolase 37

1

9

Small-scale

0.479

High

838750

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

5

Small-scale

0.479

High

838753

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

8

High-throughput

0.479

High

838761

SIR6
NAD-dependent protein deacylase sirtuin-6

1

9

High-throughput

0.479

High

838763

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

5

High-throughput

0.479

High

838765

RBP56
TATA-binding protein-associated factor 2N

1

12

High-throughput

0.479

High

838766

CSN5
COP9 signalosome complex subunit 5

1

12

High-throughput

0.479

High

838767

FUBP2
Far upstream element-binding protein 2

1

13

Small-scale

0.479

High

838771

DDRGK
DDRGK domain-containing protein 1

1

6

High-throughput

0.479

High

838773

ZN363
RING finger and CHY zinc finger domain-containing protein 1

1

4

High-throughput

0.479

High

838776

TBX5
T-box transcription factor TBX5

1

4

High-throughput

0.479

High

838777

ANM1
Protein arginine N-methyltransferase 1

1

4

High-throughput

0.479

High

838779

RIOK1
Serine/threonine-protein kinase RIO1

1

8

High-throughput

0.479

High

838781

FACD2
Fanconi anemia group D2 protein

1

11

High-throughput

0.479

High

838782

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

3

High-throughput

0.479

High

838789

PRD16
Histone-lysine N-methyltransferase PRDM16

1

5

High-throughput

0.479

High

838790

RC3H2
Roquin-2

1

11

High-throughput

0.479

High

838791

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

6

High-throughput

0.479

High

838793

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

2

High-throughput

0.479

High

838796

ANLN
Anillin

1

7

High-throughput

0.479

High

838798

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

9

High-throughput

0.479

High

838801

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

6

Small-scale

0.479

High

838803

TLS1
Splicing factor C9orf78

1

3

High-throughput

0.479

High

838804

NOP53
Ribosome biogenesis protein NOP53

1

2

High-throughput

0.479

High

838806

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

5

High-throughput

0.479

High

838807

ZRAN1
Ubiquitin thioesterase ZRANB1

1

9

High-throughput

0.479

High

838809

FZR1
Fizzy-related protein homolog

1

20

High-throughput

0.479

High

838810

PPIE
Peptidyl-prolyl cis-trans isomerase E

1

3

High-throughput

0.479

High

838811

TRI33
E3 ubiquitin-protein ligase TRIM33

1

20

High-throughput

0.479

High

838812

RRP44
Exosome complex exonuclease RRP44

1

8

Small-scale

0.479

High

838709

TAF10
Transcription initiation factor TFIID subunit 10

1

0

High-throughput

0.458

High

838728

TERF2
Telomeric repeat-binding factor 2

1

0

High-throughput

0.458

High

838780

RN126
E3 ubiquitin-protein ligase RNF126

1

0

High-throughput

0.458

High

429464

JUN
Transcription factor Jun

1

17

High-throughput

0.445

High

838720

ZN267
Zinc finger protein 267

1

1

High-throughput

0.445

High

838729

MK11
Mitogen-activated protein kinase 11

1

6

Small-scale

0.445

High

838734

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

9

High-throughput

0.445

High

838736

BTBD8
BTB/POZ domain-containing protein 8

1

7

High-throughput

0.445

High

838772

CEP63
Centrosomal protein of 63 kDa

1

12

High-throughput

0.445

High

838787

LN28A
Protein lin-28 homolog A

1

15

High-throughput

0.445

High

838805

PALS2
Protein PALS2

1

1

High-throughput

0.439

High

823869

PBX2
Pre-B-cell leukemia transcription factor 2

1

0

Small-scale

0.438

High

838722

CUL7
Cullin-7

1

5

High-throughput

0.437

High

838742

FBX42
F-box only protein 42

1

3

High-throughput

0.437

High

838759

RHG24
Rho GTPase-activating protein 24

1

4

High-throughput

0.437

High

838786

PKHA4
Pleckstrin homology domain-containing family A member 4

1

17

High-throughput

0.437

High

838800

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

3

High-throughput

0.437

High

838814

HBS1L
HBS1-like protein

1

3

High-throughput

0.437

High

132910

S28A1
Sodium/nucleoside cotransporter 1

1

0

High-throughput

0.426

High

838754

S2611
Sodium-independent sulfate anion transporter

1

0

High-throughput

0.426

High

838760

ZN808
Zinc finger protein 808

1

0

High-throughput

0.426

High

838679

CEBPA
CCAAT/enhancer-binding protein alpha

1

9

High-throughput

0.408

High

62464

S35F4
Solute carrier family 35 member F4

1

3

High-throughput

0.407

High

327849

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

16

High-throughput

0.407

High

379622

IGHA1
Immunoglobulin heavy constant alpha 1

1

2

High-throughput

0.407

High

619578

VCAM1
Vascular cell adhesion protein 1

1

4

High-throughput

0.407

High

838784

MAGT1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1

1

3

High-throughput

0.407

High

402339

GBA1
Lysosomal acid glucosylceramidase

1

0

High-throughput

0.279

Low

838705

MZT1
Mitotic-spindle organizing protein 1

1

0

High-throughput

0.279

Low

838755

COMD2
COMM domain-containing protein 2

1

0

High-throughput

0.279

Low

838684

THOP1
Thimet oligopeptidase

1

0

High-throughput

0.249

Low

838699

NDP
Norrin

1

0

Small-scale

0.249

Low

838739

GRAM4
GRAM domain-containing protein 4

1

0

Small-scale

0.249

Low

838757

SKA3
Spindle and kinetochore-associated protein 3

1

0

Small-scale

0.249

Low

838785

ATG5
Autophagy protein 5

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025