HitPredict

Interactor 1: VGFR1 (P35969)
Vascular endothelial growth factor receptor 1 (VEGFR-1) (EC 2.7.10.1) (Embryonic receptor kinase 2) (Fms-like tyrosine kinase 1) (FLT-1) (Tyrosine-protein kinase receptor FLT)
Gene: Flt1

Interactor 2: CD2AP (Q9JLQ0)
CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1)
Gene: CD2AP

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	15001553
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_1, PK_Tyr_Ser-Thr~SH3_9
Common GO terms	GO:0005886 - plasma membrane GO:0016477 - cell migration GO:0030154 - cell differentiation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1333 Mm			1 637
+	Hs
		729332 VGFR3_HUMAN (1-669): 1.25e-50: 198: 11.47		SH3K1_HUMAN (1-634): 7.55e-92: 299: 31.94
+	Hs
		452467 PGFRB_HUMAN (1-370): 1.35e-20: 100: 10.94		SH3K1_HUMAN (1-634): 7.55e-92: 299: 31.94
+	Hs
		729258 VGFR3_HUMAN (1-669): 1.25e-50: 198: 11.47		GRB2_HUMAN (111-328): 3.42e-42: 153: 20.91
+	Hs
		557624 VGFR3_HUMAN (1-669): 1.25e-50: 198: 11.47		NCK1_HUMAN (113-343): 9.96e-24: 105: 17.31
+	Hs
		609244 FGFR3_HUMAN (2-234): 1.37e-33: 142: 10.39		GRB2_HUMAN (111-328): 3.42e-42: 153: 20.91
+	Hs
		557088 PGFRA_HUMAN (1-415): 4.52e-27: 121: 12.31		GRB2_HUMAN (111-328): 3.42e-42: 153: 20.91
+	Mm
		404013 PGFRB_MOUSE (1-370): 4.58e-23: 108: 11.68		GRB2_MOUSE (111-328): 2.24e-42: 154: 20.91
+	Hs
		738192 FLT3_HUMAN (14-571): 7.83e-23: 108: 13.79		GRB2_HUMAN (111-328): 3.42e-42: 153: 20.91
+	Hs
		607935 FGFR4_HUMAN (544-798): 7e-21: 101: 15.39		GRB2_HUMAN (111-328): 3.42e-42: 153: 20.91
+	Hs
		452385 PGFRB_HUMAN (1-370): 1.35e-20: 100: 10.94		GRB2_HUMAN (111-328): 3.42e-42: 153: 20.91
+	Hs
		297957 FGFR3_HUMAN (2-234): 1.37e-33: 142: 10.39		FCSD2_HUMAN (209-417): 2.43e-15: 81.6: 22.47
+	Hs
		557606 FGFR4_HUMAN (544-798): 7e-21: 101: 15.39		NCK1_HUMAN (113-343): 9.96e-24: 105: 17.31
+	Hs
		452344 PGFRB_HUMAN (1-370): 1.35e-20: 100: 10.94		NCK1_HUMAN (113-343): 9.96e-24: 105: 17.31
+	Hs
		507832 FGFR1_HUMAN (3-163): 1.24e-17: 90.8: 11.05		NCK1_HUMAN (113-343): 9.96e-24: 105: 17.31
+	Hs
		608000 FGFR4_HUMAN (544-798): 7e-21: 101: 15.39		SH319_HUMAN (62-346): 1.05e-13: 76.6: 18.00
+	Hs
		608159 FGFR4_HUMAN (544-798): 7e-21: 101: 15.39		ITSN2_HUMAN (1-64): 4.48e-12: 71.6: 34.38
+	Hs
		208993 FGFR4_HUMAN (544-798): 7e-21: 101: 15.39		NCK2_HUMAN (240-436): 3.08e-12: 70.8: 16.16
+	Hs
		208979 PGFRB_HUMAN (1-370): 1.35e-20: 100: 10.94		NCK2_HUMAN (240-436): 3.08e-12: 70.8: 16.16
+	Hs
		607984 FGFR4_HUMAN (544-798): 7e-21: 101: 15.39		ITSN1_HUMAN (1-64): 9.85e-11: 67.3: 37.50
+	Hs
		208983 FGFR1_HUMAN (3-163): 1.24e-17: 90.8: 11.05		NCK2_HUMAN (240-436): 3.08e-12: 70.8: 16.16