HitPredict

Interactor 1: MYO3 (P36006)
Myosin-3 (Actin-dependent myosin-I MYO3) (Class I unconventional myosin MYO3) (Type I myosin MYO3)
Gene: MYO3

Interactor 2: VRP1 (P37370)
Verprolin
Gene: VRP1

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	0.60	0.751

Property	Details
Experiments	10648568, 9628892, 11743162, 11901111, 15941409, 19841731, 37968396
Identification Methods	affinity chromatography technology, two hybrid, pull down, peptide array, two hybrid pooling approach
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0006897 - endocytosis GO:0007121 - bipolar cellular bud site selection GO:0030479 - actin cortical patch GO:0051666 - actin cortical patch localization GO:2000601 - positive regulation of Arp2/3 complex-mediated actin nucleation
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 1272 Sc			1 817
+	Sc
		741558 MYO5_YEAST (1-1221): 0: 1079: 72.81		VRP1_YEAST (1-817): 1.29e-36: 150: 100.00
+	Hs
		239447 MYO10_HUMAN (18-1071): 0: 1055: 26.72		MAGC1_HUMAN (9-806): 1.39e-25: 115: 9.48
+	Hs
		203224 MYO1E_HUMAN (24-1180): 0: 1058: 37.03		SYNJ1_HUMAN (63-493): 8.24e-10: 65.1: 11.49
+	Sp
		194039 MYO1_SCHPO (24-1223): 0: 1039: 51.12		YFHH_SCHPO (1-397): 1.1e-14: 80.9: 11.81
+	Hs
		1300994 MYO5B_HUMAN (9-1146): 0: 1043: 25.02		CIC_HUMAN (10-707): 1.45e-10: 67.4: 13.59
+	Hs
		724893 MYH9_HUMAN (3-1152): 0: 1025: 22.84		MICA3_HUMAN (7-637): 5.89e-09: 62.3: 13.79
+	Hs
		297348 MYO1D_HUMAN (35-751): 7.05e-167: 525: 40.21		MDC1_HUMAN (23-817): 1.05e-25: 116: 10.81
+	Ce
		136791 HUM6_CAEEL (37-810): 2.54e-130: 444: 37.36		UNC89_CAEEL (12-540): 8.89e-25: 113: 12.73