HitPredict

Interactor 1: MYO3 (P36006)
Myosin-3 (Actin-dependent myosin-I MYO3) (Class I unconventional myosin MYO3) (Type I myosin MYO3)
Gene: MYO3

Interactor 2: ARPC1 (P38328)
Actin-related protein 2/3 complex subunit 1 (Arp2/3 complex 41 kDa subunit) (p41-ARC)
Gene: ARC40

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.639

Property	Details
Experiments	10648568, 37968396
Identification Methods	two hybrid, coimmunoprecipitation, affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0015629 - actin cytoskeleton GO:0030479 - actin cortical patch GO:0051015 - actin filament binding GO:2000601 - positive regulation of Arp2/3 complex-mediated actin nucleation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1272 Sc			1 384
+	Sc
		748555 MYO5_YEAST (1-1221): 0: 1079: 72.81		ARPC1_YEAST (1-384): 7.16e-76: 241: 96.62
+	Sp
		945010 MYO1_SCHPO (24-1223): 0: 1039: 51.12		ARPC1_SCHPO (10-384): 2.49e-84: 263: 40.21
+	Hs
		1281512 MYO5A_HUMAN (7-1141): 0: 1070: 26.03		FBXW7_HUMAN (1-321): 3.45e-66: 224: 11.89
+	Hs
		1021692 MYO1E_HUMAN (24-1180): 0: 1058: 37.03		FBXW7_HUMAN (1-321): 3.45e-66: 224: 11.89
+	Hs
		725215 MYH10_HUMAN (2-978): 0: 1043: 25.56		FBXW7_HUMAN (1-321): 3.45e-66: 224: 11.89
+	Hs
		724952 MYH9_HUMAN (3-1152): 0: 1025: 22.84		FBXW7_HUMAN (1-321): 3.45e-66: 224: 11.89
+	Hs
		903182 MYO1E_HUMAN (24-1180): 0: 1058: 37.03		WDR5_HUMAN (182-383): 7.51e-36: 135: 12.75
+	Sc
		863635 MYO5_YEAST (1-1221): 0: 1079: 72.81		COPA_YEAST (2-371): 4.32e-26: 112: 8.66
+	Hs
		728492 MYH11_HUMAN (2-1006): 0: 1025: 24.22		POC1A_HUMAN (144-384): 3.45e-45: 162: 11.93
+	Sc
		585303 MYO2_YEAST (6-979): 0: 1026: 28.98		TAF5_YEAST (2-171): 2.77e-25: 109: 12.36
+	Hs
		168832 MYO10_HUMAN (18-1071): 0: 1055: 26.72		ARC1B_HUMAN (21-245): 1.19e-12: 70.5: 8.96
+	Hs
		168742 MYH10_HUMAN (2-978): 0: 1043: 25.56		ARC1B_HUMAN (21-245): 1.19e-12: 70.5: 8.96
+	Hs
		168741 MYH9_HUMAN (3-1152): 0: 1025: 22.84		ARC1B_HUMAN (21-245): 1.19e-12: 70.5: 8.96
+	Hs
		117789 MYO1C_HUMAN (33-758): 0: 572: 41.49		FBXW7_HUMAN (1-321): 3.45e-66: 224: 11.89
+	Hs
		214638 MYO1B_HUMAN (36-730): 5.18e-167: 529: 39.80		FBXW7_HUMAN (1-321): 3.45e-66: 224: 11.89
+	Hs
		117649 MYO1C_HUMAN (33-758): 0: 572: 41.49		WDR5_HUMAN (182-383): 7.51e-36: 135: 12.75
+	Hs
		117536 MYO1C_HUMAN (33-758): 0: 572: 41.49		CIAO1_HUMAN (7-142): 6.72e-21: 94.4: 14.56
+	Hs
		117516 MYO1C_HUMAN (33-758): 0: 572: 41.49		ARC1B_HUMAN (21-245): 1.19e-12: 70.5: 8.96
+	Hs
		214444 MYO1B_HUMAN (36-730): 5.18e-167: 529: 39.80		CIAO1_HUMAN (7-142): 6.72e-21: 94.4: 14.56
+	Hs
		282792 MYO1D_HUMAN (35-751): 7.05e-167: 525: 40.21		CIAO1_HUMAN (7-142): 6.72e-21: 94.4: 14.56