HitPredict

Interactor 1: VPS21 (P36017)
Vacuolar protein sorting-associated protein 21 (GTP-binding protein YPT51) (Vacuolar protein-targeting protein 12)
Gene: VPS21

Interactor 2: GYP3 (P48566)
GTPase-activating protein GYP3 (Multicopy suppressor of bud emergence 3) (Protein MSB3)
Gene: MSB3

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.863

Property	Details
Experiments	10559187, 10937877, 22593206
Identification Methods	enzymatic study, pull down, protein complementation assay
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	RabGAP-TBC~Ras
Common GO terms	GO:0005770 - late endosome GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0006897 - endocytosis
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 210 Sc			1 633
+	Hs
		914176 RB11A_HUMAN (4-208): 7.55e-86: 254: 34.93		TBCD1_HUMAN (23-596): 1.15e-83: 286: 14.31
+	Hs
		914482 RB11A_HUMAN (4-208): 7.55e-86: 254: 34.93		RBGP1_HUMAN (31-629): 2.28e-83: 285: 16.92
+	Os
		1130874 Q7XHP7_ORYSJ (3-208): 3.25e-86: 255: 37.86		Q5SMT0_ORYSJ (27-507): 1.72e-84: 280: 16.37
+	Hs
		321281 RB11A_HUMAN (4-208): 7.55e-86: 254: 34.93		TBCD8_HUMAN (35-555): 1.65e-81: 280: 20.76
+	Os
		1130875 Q84TA8_ORYSJ (3-208): 1.01e-85: 253: 37.38		Q5SMT0_ORYSJ (27-507): 1.72e-84: 280: 16.37
+	Hs
		895536 RAB10_HUMAN (8-209): 1.71e-91: 268: 36.63		EVI5L_HUMAN (116-581): 1.48e-77: 264: 17.34
+	Os
		772871 RIC2_ORYSJ (3-209): 3.28e-84: 250: 33.33		Q5SMT0_ORYSJ (27-507): 1.72e-84: 280: 16.37
+	Hs
		234370 RB11A_HUMAN (4-208): 7.55e-86: 254: 34.93		EVI5_HUMAN (145-552): 2.64e-81: 274: 19.57
+	Hs
		234378 RB11B_HUMAN (4-210): 4.13e-84: 250: 34.60		EVI5_HUMAN (145-552): 2.64e-81: 274: 19.57
+	Hs
		914465 RB11A_HUMAN (4-208): 7.55e-86: 254: 34.93		TBD2B_HUMAN (111-573): 5.72e-78: 268: 23.03
+	Hs
		914275 RB11A_HUMAN (4-208): 7.55e-86: 254: 34.93		EVI5L_HUMAN (116-581): 1.48e-77: 264: 17.34
+	Hs
		1079952 RB11B_HUMAN (4-210): 4.13e-84: 250: 34.60		EVI5L_HUMAN (116-581): 1.48e-77: 264: 17.34
+	Hs
		914391 RB11A_HUMAN (4-208): 7.55e-86: 254: 34.93		TB22B_HUMAN (9-520): 1.34e-77: 257: 12.55
+	Dm
		185716 O18335_DROME (4-208): 6.05e-84: 249: 35.41		EVI5_DROME (124-573): 2.3e-75: 258: 19.29
+	Hs
		592434 RAB5A_HUMAN (5-209): 3.43e-64: 199: 54.63		SGSM3_HUMAN (138-571): 2.46e-79: 268: 24.37
+	Hs
		592584 RAB5A_HUMAN (5-209): 3.43e-64: 199: 54.63		TBD2B_HUMAN (111-573): 5.72e-78: 268: 23.03
+	Hs
		895374 RAB5B_HUMAN (3-180): 9.04e-64: 198: 59.55		SGSM3_HUMAN (138-571): 2.46e-79: 268: 24.37
+	Hs
		592528 RAB5A_HUMAN (5-209): 3.43e-64: 199: 54.63		TB22B_HUMAN (9-520): 1.34e-77: 257: 12.55
+	Hs
		72915 RAB5C_HUMAN (5-209): 9.43e-64: 198: 54.15		B4DMS2_HUMAN (181-571): 1.18e-75: 254: 25.51
+	Ce
		1095338 RAB10_CAEEL (8-210): 1.8e-86: 255: 34.48		Q23419_CAEEL (213-472): 1.72e-25: 114: 30.45