HitPredict

Interactor 1: I5P2 (P32019)
Type II inositol 1,4,5-trisphosphate 5-phosphatase (EC 3.1.3.36) (75 kDa inositol polyphosphate-5-phosphatase) (Phosphoinositide 5-phosphatase) (5PTase)
Gene: INPP5B

Interactor 2: OCRL (Q01968)
Inositol polyphosphate 5-phosphatase OCRL (EC 3.1.3.36) (EC 3.1.3.56) (Inositol polyphosphate 5-phosphatase OCRL-1) (OCRL-1) (Lowe oculocerebrorenal syndrome protein) (Phosphatidylinositol 3,4,5-triphosphate 5-phosphatase) (EC 3.1.3.86)
Gene: OCRL

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.65 1.00 0.811

The method score is based on:

Property Details
Experiments 28514442, 33961781
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Exo_endo_phos2~Exo_endo_phos2, OCRL-like_ASH~OCRL-like_ASH, OCRL-like_ASH~RhoGAP, RhoGAP~RhoGAP
Common GO terms GO:0001701 - in utero embryonic development
GO:0004439 - phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane
and 9 others

more...
Homologous interactions 4

Homologous interactions

Color coding for hit scores

1 993
Hs

1 901
+ Hs
+ Hs
+ Hs
+ Dm

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Last updated: 11Aug2025