Protein: SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (EC 3.1.3.86) (Inositol polyphosphate phosphatase-like protein 1) (INPPL-1) (Protein 51C) (SH2 domain-containing inositol 5'-phosphatase 2) (SH2 domain-containing inositol phosphatase 2) (SHIP-2)

Gene: SHIP2, INPPL1
Organism: Homo sapiens
Interactions: 199
UniProt ID: O15357

Gene Ontology (top 5):
GO:0000132 - establishment of mitotic spindle orientation
GO:0000922 - spindle pole
GO:0001958 - endochondral ossification
GO:0002376 - immune system process
GO:0003779 - actin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

187296

SHC1
SHC-transforming protein 1

4

20

Small-scale

0.886

High

187239

EGFR
Epidermal growth factor receptor

4

12

Small-scale

0.873

High

187330

GRB2
Growth factor receptor-bound protein 2

2

20

High-throughput

0.820

High

187319

STAT2
Signal transducer and activator of transcription 2

2

1

High-throughput

0.811

High

187413

SMAG1
Protein Smaug homolog 1

2

1

High-throughput

0.811

High

187259

MET
Hepatocyte growth factor receptor

2

9

Small-scale

0.789

High

187295

EPHA2
Ephrin type-A receptor 2

2

10

Small-scale

0.789

High

187359

SMAG2
Protein Smaug homolog 2

2

1

High-throughput

0.789

High

187379

PACE1
Protein-associating with the carboxyl-terminal domain of ezrin

2

2

High-throughput

0.776

High

187325

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

15

Small-scale

0.761

High

187403

SRBS1
Sorbin and SH3 domain-containing protein 1

1

20

Small-scale

0.756

High

187238

ABL1
Tyrosine-protein kinase ABL1

2

17

Small-scale

0.754

High

187384

ARAP3
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3

1

8

Small-scale

0.740

High

187228

M3K13
Mitogen-activated protein kinase kinase kinase 13

2

9

High-throughput

0.726

High

136234

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

1

20

High-throughput

0.691

High

187294

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

5

High-throughput

0.691

High

187297

MK04
Mitogen-activated protein kinase 4

1

4

High-throughput

0.691

High

187308

STAT6
Signal transducer and activator of transcription 6

1

1

High-throughput

0.691

High

187310

CRK
Adapter molecule crk

1

20

High-throughput

0.691

High

187338

CDK16
Cyclin-dependent kinase 16

1

1

High-throughput

0.691

High

187289

CBL
E3 ubiquitin-protein ligase CBL

4

3

Small-scale

0.686

High

187354

ITSN1
Intersectin-1

1

15

Small-scale

0.683

High

187251

INSR
Insulin receptor

2

14

Small-scale

0.675

High

187292

EF1G
Elongation factor 1-gamma

3

2

High-throughput

0.667

High

187298

RIR2
Ribonucleoside-diphosphate reductase subunit M2

3

1

High-throughput

0.667

High

187340

PLIN5
Perilipin-5

3

1

High-throughput

0.667

High

187368

RIR2B
Ribonucleoside-diphosphate reductase subunit M2 B

3

1

High-throughput

0.667

High

187396

ALKB3
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3

3

1

High-throughput

0.667

High

187309

EAA3
Excitatory amino acid transporter 3

3

1

High-throughput

0.662

High

187382

ARFG1
ADP-ribosylation factor GTPase-activating protein 1

3

2

High-throughput

0.662

High

187387

ARAP2
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2

2

4

High-throughput

0.659

High

187361

KAZRN
Kazrin

1

0

High-throughput

0.656

High

187232

VINEX
Vinexin

1

20

Small-scale

0.653

High

187246

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

11

High-throughput

0.647

High

187288

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

14

High-throughput

0.647

High

187353

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

12

High-throughput

0.647

High

187380

ABI1
Abl interactor 1

1

18

Small-scale

0.647

High

187356

DDR2
Discoidin domain-containing receptor 2

1

20

High-throughput

0.646

High

187301

PPM1A
Protein phosphatase 1A

3

0

High-throughput

0.638

High

187320

TF2AA
Transcription initiation factor IIA subunit 1

3

0

High-throughput

0.638

High

187405

BHMT2
S-methylmethionine--homocysteine S-methyltransferase BHMT2

3

0

High-throughput

0.638

High

72376

A9UF07
Tyrosine-protein kinase ABL1

1

19

High-throughput

0.625

High

154408

SH2B2
SH2B adapter protein 2

1

20

Small-scale

0.618

High

187247

NTRK1
High affinity nerve growth factor receptor

1

15

High-throughput

0.618

High

187257

LYN
Tyrosine-protein kinase Lyn

1

17

High-throughput

0.618

High

187269

BCR
Breakpoint cluster region protein

1

7

High-throughput

0.618

High

187315

GSK3A
Glycogen synthase kinase-3 alpha

1

2

High-throughput

0.618

High

187316

GSK3B
Glycogen synthase kinase-3 beta

1

1

High-throughput

0.618

High

187358

LRRK1
Leucine-rich repeat serine/threonine-protein kinase 1

1

3

High-throughput

0.618

High

187366

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.618

High

187390

SHIP1
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

1

3

High-throughput

0.618

High

187406

PTN23
Tyrosine-protein phosphatase non-receptor type 23

1

2

Small-scale

0.618

High

187418

CD2AP
CD2-associated protein

1

20

Small-scale

0.618

High

187253

ENOA
Alpha-enolase

2

1

High-throughput

0.611

High

187255

PROF1
Profilin-1

2

3

High-throughput

0.611

High

187370

MILR1
Allergin-1

3

7

High-throughput

0.604

High

187386

ACO12
Acetyl-coenzyme A thioesterase

2

0

High-throughput

0.602

High

187398

DPYL5
Dihydropyrimidinase-related protein 5

2

0

High-throughput

0.602

High

187343

PSME1
Proteasome activator complex subunit 1

2

1

High-throughput

0.601

High

187328

RHOB
Rho-related GTP-binding protein RhoB

2

7

High-throughput

0.584

High

187393

SH3K1
SH3 domain-containing kinase-binding protein 1

2

20

Small-scale

0.584

High

187287

EPHA1
Ephrin type-A receptor 1

1

5

Small-scale

0.579

High

187401

LRC61
Leucine-rich repeat-containing protein 61

1

0

High-throughput

0.578

High

187407

CA198
Uncharacterized protein C1orf198

2

0

High-throughput

0.576

High

187344

DDR1
Epithelial discoidin domain-containing receptor 1

1

19

Small-scale

0.575

High

187377

S22A9
Organic anion transporter 7

2

1

High-throughput

0.574

High

187285

VCAM1
Vascular cell adhesion protein 1

2

3

High-throughput

0.571

High

187375

HID1
Protein HID1

1

0

Small-scale

0.558

High

187376

M4K3
Mitogen-activated protein kinase kinase kinase kinase 3

1

1

High-throughput

0.553

High

187352

FLNC
Filamin-C

1

6

Small-scale

0.552

High

187350

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

1

0

High-throughput

0.546

High

187266

ANDR
Androgen receptor

1

2

High-throughput

0.536

High

187347

GAB1
GRB2-associated-binding protein 1

1

4

High-throughput

0.536

High

187230

ACTN4
Alpha-actinin-4

1

2

High-throughput

0.536

High

187231

AK1BA
Aldo-keto reductase family 1 member B10

1

3

High-throughput

0.536

High

187243

ANXA1
Annexin A1

1

2

High-throughput

0.536

High

187249

PCCB
Propionyl-CoA carboxylase beta chain, mitochondrial

1

2

High-throughput

0.536

High

187273

ACTN1
Alpha-actinin-1

1

2

High-throughput

0.536

High

187278

ALDR
Aldo-keto reductase family 1 member B1

1

3

High-throughput

0.536

High

187283

ARF4
ADP-ribosylation factor 4

1

5

High-throughput

0.536

High

187284

VINC
Vinculin

1

2

High-throughput

0.536

High

187321

AK1C2
Aldo-keto reductase family 1 member C2

1

3

High-throughput

0.536

High

187329

RAN
GTP-binding nuclear protein Ran

1

13

High-throughput

0.536

High

187332

TYB10
Thymosin beta-10

1

1

High-throughput

0.536

High

187369

MYH14
Myosin-14

1

2

High-throughput

0.536

High

187383

UBS3B
Ubiquitin-associated and SH3 domain-containing protein B

1

20

High-throughput

0.536

High

187409

MCCB
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial

1

2

High-throughput

0.536

High

187410

NECP2
Adaptin ear-binding coat-associated protein 2

1

2

High-throughput

0.536

High

187241

CD4
T-cell surface glycoprotein CD4

1

0

High-throughput

0.518

High

187233

UGDH
UDP-glucose 6-dehydrogenase

1

0

High-throughput

0.513

High

187235

BAF
Barrier-to-autointegration factor

1

0

High-throughput

0.513

High

187236

SPF27
Pre-mRNA-splicing factor SPF27

1

0

High-throughput

0.513

High

187237

AL1A1
Aldehyde dehydrogenase 1A1

1

0

High-throughput

0.513

High

187240

PGK1
Phosphoglycerate kinase 1

1

0

High-throughput

0.513

High

187252

PTMA
Prothymosin alpha [Cleaved into: Prothymosin alpha, N-terminally processed; Thymosin alpha-1]

1

0

High-throughput

0.513

High

187256

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

0

High-throughput

0.513

High

187261

GSTP1
Glutathione S-transferase P

1

0

High-throughput

0.513

High

187272

RLBP1
Retinaldehyde-binding protein 1

1

0

High-throughput

0.513

High

187279

NQO1
NAD(P)H dehydrogenase [quinone] 1

1

0

High-throughput

0.513

High

187290

SAHH
Adenosylhomocysteinase

1

0

High-throughput

0.513

High

187303

TALDO
Transaldolase

1

0

High-throughput

0.513

High

187306

MDHC
Malate dehydrogenase, cytoplasmic

1

0

High-throughput

0.513

High

187307

NAA10
N-alpha-acetyltransferase 10

1

0

High-throughput

0.513

High

187322

ACLY
ATP-citrate synthase

1

0

High-throughput

0.513

High

187323

SUMO3
Small ubiquitin-related modifier 3

1

0

High-throughput

0.513

High

187327

TYB4
Thymosin beta-4

1

0

High-throughput

0.513

High

187337

BASP1
Brain acid soluble protein 1

1

0

High-throughput

0.513

High

187345

AHNK
Neuroblast differentiation-associated protein AHNAK

1

0

High-throughput

0.513

High

187364

DCNL2
DCN1-like protein 2

1

0

High-throughput

0.513

High

187365

SCIMP
SLP adapter and CSK-interacting membrane protein

1

0

High-throughput

0.513

High

187371

MTA70
N(6)-adenosine-methyltransferase catalytic subunit METTL3

1

0

High-throughput

0.513

High

187374

TCAM1
TIR domain-containing adapter molecule 1

1

0

High-throughput

0.513

High

187378

CMIP
C-Maf-inducing protein

1

0

High-throughput

0.513

High

187389

THRSP
Thyroid hormone-inducible hepatic protein

1

0

High-throughput

0.513

High

187415

PSF2
DNA replication complex GINS protein PSF2

1

0

High-throughput

0.513

High

187411

PLEK2
Pleckstrin-2

1

4

Small-scale

0.512

High

187264

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

4

Small-scale

0.501

High

187324

NDK5
Nucleoside diphosphate kinase homolog 5

1

1

High-throughput

0.489

High

141210

DDX3X
ATP-dependent RNA helicase DDX3X

1

1

High-throughput

0.479

High

172275

XPO1
Exportin-1

1

6

High-throughput

0.479

High

187234

PEX14
Peroxisomal membrane protein PEX14

1

1

High-throughput

0.479

High

187242

K1C14
Keratin, type I cytoskeletal 14

1

11

High-throughput

0.479

High

187244

K2C6B
Keratin, type II cytoskeletal 6B

1

8

High-throughput

0.479

High

187245

K2C1
Keratin, type II cytoskeletal 1

1

7

High-throughput

0.479

High

187248

ADT2
ADP/ATP translocase 2

1

1

High-throughput

0.479

High

187254

TBB5
Tubulin beta chain

1

4

High-throughput

0.479

High

187258

HS90B
Heat shock protein HSP 90-beta

1

4

High-throughput

0.479

High

187260

K1C16
Keratin, type I cytoskeletal 16

1

11

High-throughput

0.479

High

187267

BIP
Endoplasmic reticulum chaperone BiP

1

3

High-throughput

0.479

High

187268

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.479

High

187270

K2C3
Keratin, type II cytoskeletal 3

1

8

High-throughput

0.479

High

187271

ADT3
ADP/ATP translocase 3

1

1

High-throughput

0.479

High

187274

CADH1
Cadherin-1

1

2

High-throughput

0.479

High

187276

K1C10
Keratin, type I cytoskeletal 10

1

12

High-throughput

0.479

High

187277

K2C5
Keratin, type II cytoskeletal 5

1

7

High-throughput

0.479

High

187281

HSP76
Heat shock 70 kDa protein 6

1

2

High-throughput

0.479

High

187282

DDX5
Probable ATP-dependent RNA helicase DDX5

1

1

High-throughput

0.479

High

187291

DDX6
Probable ATP-dependent RNA helicase DDX6

1

3

High-throughput

0.479

High

187293

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

187299

HS71L
Heat shock 70 kDa protein 1-like

1

2

High-throughput

0.479

High

187300

K1C9
Keratin, type I cytoskeletal 9

1

12

High-throughput

0.479

High

187302

K22E
Keratin, type II cytoskeletal 2 epidermal

1

8

High-throughput

0.479

High

187311

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

5

High-throughput

0.479

High

187313

K2C6C
Keratin, type II cytoskeletal 6C

1

7

High-throughput

0.479

High

187317

VASP
Vasodilator-stimulated phosphoprotein

1

3

High-throughput

0.479

High

187331

RAC1
Ras-related C3 botulinum toxin substrate 1

1

5

High-throughput

0.479

High

187335

TBB4B
Tubulin beta-4B chain

1

4

High-throughput

0.479

High

187341

K1C17
Keratin, type I cytoskeletal 17

1

11

High-throughput

0.479

High

187342

1433F
14-3-3 protein eta

1

17

High-throughput

0.479

High

187346

ACACA
Acetyl-CoA carboxylase 1

1

1

High-throughput

0.479

High

187349

TBB3
Tubulin beta-3 chain

1

4

High-throughput

0.479

High

187355

CCDC6
Coiled-coil domain-containing protein 6

1

4

High-throughput

0.479

High

187360

K2C79
Keratin, type II cytoskeletal 79

1

7

High-throughput

0.479

High

187362

A16L1
Autophagy-related protein 16-1

1

3

High-throughput

0.479

High

187373

K2C73
Keratin, type II cytoskeletal 73

1

6

High-throughput

0.479

High

187388

ESR2
Estrogen receptor beta

1

2

High-throughput

0.479

High

187400

TBB6
Tubulin beta-6 chain

1

4

High-throughput

0.479

High

187402

TBB2B
Tubulin beta-2B chain

1

4

High-throughput

0.479

High

187419

MTCH2
Mitochondrial carrier homolog 2

1

2

High-throughput

0.479

High

187250

RLA0
Large ribosomal subunit protein uL10

1

0

High-throughput

0.458

High

187280

H12
Histone H1.2

1

0

High-throughput

0.458

High

187305

RS19
Small ribosomal subunit protein eS19

1

0

High-throughput

0.458

High

187314

TCPG
T-complex protein 1 subunit gamma

1

0

High-throughput

0.458

High

187333

EF1A1
Elongation factor 1-alpha 1

1

0

High-throughput

0.458

High

187336

GTF2I
General transcription factor II-I

1

0

High-throughput

0.458

High

187339

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

0

High-throughput

0.458

High

187348

SMAD4
Mothers against decapentaplegic homolog 4

1

0

High-throughput

0.458

High

187351

CUL4A
Cullin-4A

1

0

Small-scale

0.458

High

187399

DIDO1
Death-inducer obliterator 1

1

0

High-throughput

0.458

High

187412

WWOX
WW domain-containing oxidoreductase

1

0

High-throughput

0.458

High

187414

ZN148
Zinc finger protein 148

1

0

High-throughput

0.458

High

104864

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

187304

HSPA9
Stress-70 protein, mitochondrial

1

5

High-throughput

0.437

High

187334

TBA1B
Tubulin alpha-1B chain

1

2

High-throughput

0.437

High

187392

VP33A
Vacuolar protein sorting-associated protein 33A

1

2

High-throughput

0.437

High

142240

PEX7
Peroxisomal targeting signal 2 receptor

1

0

High-throughput

0.426

High

187265

RPC22
Protein POLR1D, isoform 2

1

0

High-throughput

0.426

High

187262

MYZAP
Myocardial zonula adherens protein

1

2

High-throughput

0.407

High

187404

CD244
Natural killer cell receptor 2B4

1

7

Small-scale

0.407

High

187397

PCY2
Ethanolamine-phosphate cytidylyltransferase

3

0

High-throughput

0.345

High

187363

GL1AD
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5

3

0

High-throughput

0.334

High

187229

TPD54
Tumor protein D54

2

0

High-throughput

0.328

High

187408

CIAO3
Cytosolic iron-sulfur assembly component 3

2

0

High-throughput

0.328

High

187417

T184B
Transmembrane protein 184B

2

0

High-throughput

0.328

High

187326

VA0D1
V-type proton ATPase subunit d 1

2

0

High-throughput

0.318

High

187395

DYDC2
DPY30 domain-containing protein 2

2

0

High-throughput

0.318

High

187312

GLR
Glucagon receptor

1

0

High-throughput

0.279

Low

187357

INSY1
Inhibitory synaptic factor 1

1

0

High-throughput

0.279

Low

187367

BOP
Protein Bop

1

0

High-throughput

0.279

Low

187381

SYCE1
Synaptonemal complex central element protein 1

1

0

High-throughput

0.279

Low

187385

IL1FA
Interleukin-1 family member 10

1

0

High-throughput

0.279

Low

187416

AFG32
Mitochondrial inner membrane m-AAA protease component AFG3L2

1

0

High-throughput

0.279

Low

187286

EFNA1
Ephrin-A1

1

0

Small-scale

0.261

Low

187275

ITA4
Integrin alpha-4

1

0

High-throughput

0.249

Low

187318

XK
Endoplasmic reticulum membrane adapter protein XK

1

0

High-throughput

0.249

Low

187394

BORC6
BLOC-1-related complex subunit 6

1

0

High-throughput

0.249

Low

187263

GRL1A
DNA-directed RNA polymerase II subunit GRINL1A

1

0

High-throughput

0.232

Low

187372

P2RY8
S-geranylgeranyl-glutathione receptor P2RY8

1

0

High-throughput

0.232

Low

187391

P33MX
Putative monooxygenase p33MONOX

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025