Protein: SHIP1
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (EC 3.1.3.86) (Inositol polyphosphate-5-phosphatase D) (EC 3.1.3.56) (Inositol polyphosphate-5-phosphatase of 145 kDa) (SIP-145) (Phosphatidylinositol 4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (SH2 domain-containing inositol 5'-phosphatase 1) (SH2 domain-containing inositol phosphatase 1) (SHIP-1) (p150Ship) (hp51CN)

Gene: SHIP1, INPP5D
Organism: Homo sapiens
Interactions: 70
UniProt ID: Q92835

Gene Ontology (top 5):
GO:0004439 - phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
GO:0004445 - inositol-polyphosphate 5-phosphatase activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005856 - cytoskeleton

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

711388

SHC1
SHC-transforming protein 1

9

20

Small-scale

0.962

High

987815

GRB2
Growth factor receptor-bound protein 2

5

20

Small-scale

0.909

High

1053716

PTN11
Tyrosine-protein phosphatase non-receptor type 11

3

1

Small-scale

0.814

High

619228

EPOR
Erythropoietin receptor

2

2

Small-scale

0.786

High

699818

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

2

5

Small-scale

0.776

High

463691

LYN
Tyrosine-protein kinase Lyn

1

20

Small-scale

0.747

High

855915

CRKL
Crk-like protein

1

20

Small-scale

0.724

High

731813

FCG2B
Low affinity immunoglobulin gamma Fc region receptor II-b

5

8

Small-scale

0.692

High

463184

YES
Tyrosine-protein kinase Yes

1

20

High-throughput

0.647

High

532097

KIT
Mast/stem cell growth factor receptor Kit

1

7

Small-scale

0.647

High

855711

CRK
Adapter molecule crk

1

20

High-throughput

0.647

High

1005370

SHPS1
Tyrosine-protein phosphatase non-receptor type substrate 1

1

1

Small-scale

0.647

High

284706

KHDR3
KH domain-containing, RNA-binding, signal transduction-associated protein 3

3

0

High-throughput

0.646

High

1369277

DOK1
Docking protein 1

3

7

Small-scale

0.646

High

1157021

NTRK3
NT-3 growth factor receptor

1

14

High-throughput

0.646

High

1101292

SLAF1
Signaling lymphocytic activation molecule

2

15

Small-scale

0.639

High

1369278

CD244
Natural killer cell receptor 2B4

2

13

Small-scale

0.625

High

187390

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

1

3

High-throughput

0.618

High

473456

HCK
Tyrosine-protein kinase HCK

1

20

Small-scale

0.618

High

540063

BCR
Breakpoint cluster region protein

1

9

Small-scale

0.618

High

594067

NCK1
SH2/SH3 adapter protein NCK1

1

20

Small-scale

0.618

High

787059

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

7

Small-scale

0.618

High

849217

KSYK
Tyrosine-protein kinase SYK

1

20

Small-scale

0.618

High

1051952

KPCD
Protein kinase C delta type

1

1

Small-scale

0.618

High

1150885

CIP4
Cdc42-interacting protein 4

1

6

Small-scale

0.618

High

1369280

SLAF7
SLAM family member 7

1

16

Small-scale

0.618

High

1369284

CD2AP
CD2-associated protein

1

20

Small-scale

0.618

High

1369275

SH3K1
SH3 domain-containing kinase-binding protein 1

2

20

Small-scale

0.606

High

1307429

KRA13
Keratin-associated protein 1-3

2

3

High-throughput

0.606

High

1193159

TIGIT
T-cell immunoreceptor with Ig and ITIM domains

1

0

Small-scale

0.586

High

1369281

TLR9
Toll-like receptor 9

1

0

Small-scale

0.586

High

1369283

TRAF6
TNF receptor-associated factor 6

2

3

Small-scale

0.584

High

164867

SH21B
SH2 domain-containing protein 1B

1

20

Small-scale

0.575

High

1063001

DDR1
Epithelial discoidin domain-containing receptor 1

1

20

Small-scale

0.575

High

950356

KR107
Keratin-associated protein 10-7

1

3

High-throughput

0.573

High

950851

KR109
Keratin-associated protein 10-9

1

3

High-throughput

0.573

High

1146082

K1H1
Keratin, type I cuticular Ha1

1

12

High-throughput

0.573

High

1230177

K1C40
Keratin, type I cytoskeletal 40

1

11

High-throughput

0.573

High

1277342

NT2NA
Notch homolog 2 N-terminal-like protein A

1

1

High-throughput

0.573

High

1022759

XIAP
E3 ubiquitin-protein ligase XIAP

1

1

Small-scale

0.552

High

593774

PECA1
Platelet endothelial cell adhesion molecule

1

5

Small-scale

0.536

High

1369274

SHIP1
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

1

3

Small-scale

0.527

High

665049

IL4RA
Interleukin-4 receptor subunit alpha

1

1

Small-scale

0.516

High

470326

NEP
Neprilysin

1

0

Small-scale

0.513

High

1022187

DAB2
Disabled homolog 2

1

3

Small-scale

0.501

High

1369279

LY9
T-lymphocyte surface antigen Ly-9

1

16

Small-scale

0.501

High

1307591

ZDH17
Palmitoyltransferase ZDHHC17

1

1

High-throughput

0.494

High

601793

HMGA1
High mobility group protein HMG-I/HMG-Y

1

0

High-throughput

0.493

High

1186785

KRA63
Keratin-associated protein 6-3

1

0

High-throughput

0.493

High

286399

DAB1
Disabled homolog 1

1

6

Small-scale

0.481

High

949958

KR103
Keratin-associated protein 10-3

1

3

High-throughput

0.481

High

1369276

ARAP1
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1

1

5

Small-scale

0.481

High

242478

PRKN
E3 ubiquitin-protein ligase parkin

1

7

High-throughput

0.479

High

249767

DOK2
Docking protein 2

1

8

Small-scale

0.479

High

629550

CD22
B-cell receptor CD22

1

6

Small-scale

0.479

High

651393

CBL
E3 ubiquitin-protein ligase CBL

1

3

Small-scale

0.479

High

1140645

KIF14
Kinesin-like protein KIF14

1

3

High-throughput

0.479

High

1182849

LRRK1
Leucine-rich repeat serine/threonine-protein kinase 1

1

3

High-throughput

0.479

High

1227189

A16L1
Autophagy-related protein 16-1

1

3

High-throughput

0.479

High

1272289

DOK3
Docking protein 3

1

7

Small-scale

0.479

High

1353517

UBS3B
Ubiquitin-associated and SH3 domain-containing protein B

1

20

Small-scale

0.479

High

692109

MARK3
MAP/microtubule affinity-regulating kinase 3

1

0

Small-scale

0.458

High

1369282

AGO2
Protein argonaute-2

1

0

Small-scale

0.458

High

622652

TNR1A
Tumor necrosis factor receptor superfamily member 1A

1

2

Small-scale

0.445

High

675096

TNR6
Tumor necrosis factor receptor superfamily member 6

1

2

Small-scale

0.445

High

1366350

FCGRB
Putative high affinity immunoglobulin gamma Fc receptor IB

1

8

Small-scale

0.408

High

70400

CRTP1
Cysteine-rich tail protein 1

2

0

High-throughput

0.316

High

1322290

CLYBL
Citramalyl-CoA lyase, mitochondrial

1

0

Small-scale

0.249

Low

887073

CEBPA
CCAAT/enhancer-binding protein alpha

1

0

High-throughput

0.213

Low


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Last updated: 11Aug2025