HitPredict

Interactor 1: TRI23 (P36406)
E3 ubiquitin-protein ligase TRIM23 (EC 2.3.2.27) (ADP-ribosylation factor domain-containing protein 1) (GTP-binding protein ARD-1) (RING finger protein 46) (RING-type E3 ubiquitin transferase TRIM23) (Tripartite motif-containing protein 23)
Gene: TRIM23

Interactor 2: UB2L3 (P68036)
Ubiquitin-conjugating enzyme E2 L3 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme L3) (L-UBC) (UbcH7) (Ubiquitin carrier protein L3) (Ubiquitin-conjugating enzyme E2-F1) (Ubiquitin-protein ligase L3)
Gene: UBE2L3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	29643511
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	UQ_con~zf-RING_UBOX
Common GO terms	GO:0004842 - ubiquitin-protein transferase activity GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0016567 - protein ubiquitination
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 574 Hs			1 154
+	Hs
		734819 TRI23_HUMAN (1-574): 1.73e-139: 418: 100.00		UB2D4_HUMAN (2-149): 6.75e-76: 224: 38.93
+	Hs
		734563 TRI23_HUMAN (1-574): 1.73e-139: 418: 100.00		UB2D1_HUMAN (2-149): 5.66e-75: 221: 38.26
+	Hs
		734581 TRI23_HUMAN (1-574): 1.73e-139: 418: 100.00		UB2D2_HUMAN (2-149): 7.95e-75: 221: 37.58
+	Hs
		734570 TRI23_HUMAN (1-574): 1.73e-139: 418: 100.00		UB2D3_HUMAN (2-149): 8.29e-74: 218: 36.91
+	Hs
		734733 TRI23_HUMAN (1-574): 1.73e-139: 418: 100.00		UB2E2_HUMAN (2-149): 1.55e-68: 207: 34.90
+	Hs
		734564 TRI23_HUMAN (1-574): 1.73e-139: 418: 100.00		UB2E1_HUMAN (2-149): 6.55e-67: 203: 34.90
+	Hs
		895769 ARF6_HUMAN (399-567): 3.05e-87: 269: 54.44		UB2D3_HUMAN (2-149): 8.29e-74: 218: 36.91
+	Hs
		1356055 TRIM1_HUMAN (21-400): 5.38e-69: 238: 19.51		UB2D4_HUMAN (2-149): 6.75e-76: 224: 38.93
+	Hs
		1151762 Q6GX22_HUMAN (23-400): 6.72e-69: 237: 19.60		UB2D4_HUMAN (2-149): 6.75e-76: 224: 38.93
+	Hs
		849480 TRIM1_HUMAN (21-400): 5.38e-69: 238: 19.51		UB2D1_HUMAN (2-149): 5.66e-75: 221: 38.26
+	Hs
		919896 TRIM1_HUMAN (21-400): 5.38e-69: 238: 19.51		UB2D2_HUMAN (2-149): 7.95e-75: 221: 37.58
+	Hs
		895945 TRIM1_HUMAN (21-400): 5.38e-69: 238: 19.51		UB2D3_HUMAN (2-149): 8.29e-74: 218: 36.91
+	Hs
		1282363 TRIM1_HUMAN (21-400): 5.38e-69: 238: 19.51		UB2E3_HUMAN (2-149): 2.39e-68: 207: 34.90
+	Hs
		1297378 TRIM1_HUMAN (21-400): 5.38e-69: 238: 19.51		UB2E2_HUMAN (2-149): 1.55e-68: 207: 34.90
+	Hs
		851905 TRIM1_HUMAN (21-400): 5.38e-69: 238: 19.51		UB2E1_HUMAN (2-149): 6.55e-67: 203: 34.90