Protein: PHLP2
PH domain leucine-rich repeat-containing protein phosphatase 2 (EC 3.1.3.16) (PH domain leucine-rich repeat-containing protein phosphatase-like) (PHLPP-like)

Gene: PHLP2, PHLPP2
Organism: Homo sapiens
Interactions: 36
UniProt ID: Q6ZVD8

Gene Ontology (top 5):
GO:0001917 - photoreceptor inner segment
GO:0004722 - protein serine/threonine phosphatase activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

247360

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

2

19

High-throughput

0.811

High

728306

AKT1
RAC-alpha serine/threonine-protein kinase

2

16

Small-scale

0.798

High

967155

UBP46
Ubiquitin carboxyl-terminal hydrolase 46

6

5

High-throughput

0.735

High

1256829

WDR48
WD repeat-containing protein 48

5

5

Small-scale

0.718

High

1256830

WDR20
WD repeat-containing protein 20

4

5

Small-scale

0.699

High

162845

NHRF1
Na(+)/H(+) exchange regulatory cofactor NHE-RF1

3

17

Small-scale

0.689

High

1150442

NHRF2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2

3

17

High-throughput

0.675

High

275901

UBP12
Ubiquitin carboxyl-terminal hydrolase 12

3

5

Small-scale

0.667

High

317189

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

3

7

Small-scale

0.667

High

436690

KPCB
Protein kinase C beta type

1

12

Small-scale

0.665

High

1256827

DAA11
Dynein axonemal assembly factor 11

2

20

High-throughput

0.628

High

1256833

SNX27
Sorting nexin-27

2

15

High-throughput

0.628

High

728602

AKT2
RAC-beta serine/threonine-protein kinase

1

16

Small-scale

0.618

High

1062382

PP2BA
Protein phosphatase 3 catalytic subunit alpha

1

15

Small-scale

0.618

High

1256839

AKT3
RAC-gamma serine/threonine-protein kinase

1

15

Small-scale

0.618

High

658610

KS6B1
Ribosomal protein S6 kinase beta-1

1

15

Small-scale

0.575

High

1256834

VAT1
Synaptic vesicle membrane protein VAT-1 homolog

2

2

High-throughput

0.574

High

582849

EZRI
Ezrin

1

9

High-throughput

0.536

High

761730

HSP74
Heat shock 70 kDa protein 4

1

6

High-throughput

0.536

High

810176

RL3
Large ribosomal subunit protein uL3

1

1

High-throughput

0.536

High

1066233

DMWD
Dystrophia myotonica WD repeat-containing protein

1

7

High-throughput

0.536

High

1256832

HS105
Heat shock protein 105 kDa

1

6

High-throughput

0.536

High

1256840

SGT1
Protein SGT1 homolog

1

17

High-throughput

0.536

High

973481

RS11
Small ribosomal subunit protein uS17

1

1

High-throughput

0.515

High

767462

RADI
Radixin

1

7

High-throughput

0.489

High

951726

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

1

Small-scale

0.479

High

1105978

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

7

Small-scale

0.479

High

1113488

CUL3
Cullin-3

1

6

Small-scale

0.479

High

1256828

RN149
E3 ubiquitin-protein ligase RNF149

1

4

Small-scale

0.479

High

1256831

MARH1
E3 ubiquitin-protein ligase MARCHF1

1

1

Small-scale

0.479

High

1256835

TCPH
T-complex protein 1 subunit eta

1

2

High-throughput

0.479

High

1256836

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

1

High-throughput

0.479

High

1256837

AKTIP
AKT-interacting protein

1

1

Small-scale

0.479

High

1256838

FANCI
Fanconi anemia group I protein

1

1

Small-scale

0.479

High

1256826

TRI46
Tripartite motif-containing protein 46

1

11

Small-scale

0.437

High

705429

GRN
Progranulin

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025