HitPredict

Interactor 1: MP2K2 (P36507)
Dual specificity mitogen-activated protein kinase kinase 2 (MAP kinase kinase 2) (MAPKK 2) (EC 2.7.12.2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK 2)
Gene: MAP2K2

Interactor 2: TBB4B (P68371)
Tubulin beta-4B chain (Tubulin beta-2 chain) (Tubulin beta-2C chain)
Gene: TUBB4B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	31980649, unassigned2173
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005576 - extracellular region GO:0005634 - nucleus GO:0005829 - cytosol GO:0005874 - microtubule GO:0046872 - metal ion binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 400 Hs			1 445
+	Hs
		1023062 STK4_HUMAN (41-377): 2.43e-109: 331: 28.74		Q6LC01_HUMAN (8-443): 0: 890: 96.79
+	Hs
		734927 MP2K2_HUMAN (1-400): 1.09e-125: 370: 100.00		TBB3_HUMAN (1-443): 0: 714: 93.23
+	Hs
		428055 MP2K2_HUMAN (1-400): 1.09e-125: 370: 100.00		TBB5_HUMAN (1-429): 0: 711: 98.37
+	Hs
		428041 AKT1_HUMAN (43-351): 3.37e-124: 369: 20.12		TBB5_HUMAN (1-429): 0: 711: 98.37
+	Hs
		681781 AKT1_HUMAN (43-351): 3.37e-124: 369: 20.12		TBB4B_HUMAN (1-427): 0: 711: 100.00
+	Hs
		381138 MP2K2_HUMAN (1-400): 1.09e-125: 370: 100.00		TBB4A_HUMAN (1-427): 0: 706: 98.60
+	Hs
		625344 CDK2_HUMAN (69-375): 3.95e-124: 362: 25.16		TBB4B_HUMAN (1-427): 0: 711: 100.00
+	Hs
		568654 KAPCA_HUMAN (32-347): 6.67e-122: 358: 22.99		TBB3_HUMAN (1-443): 0: 714: 93.23
+	Hs
		625420 CDK2_HUMAN (69-375): 3.95e-124: 362: 25.16		TBB2A_HUMAN (1-430): 0: 707: 97.67
+	Dm
		445198 AKT1_DROME (53-350): 7.38e-123: 370: 21.77		TBB3_DROME (1-445): 0: 698: 89.14
+	Dm
		1213355 AKT1_DROME (53-350): 7.38e-123: 370: 21.77		Q8MST5_DROME (1-445): 0: 696: 88.09
+	Hs
		568659 KAPCA_HUMAN (32-347): 6.67e-122: 358: 22.99		TBB2A_HUMAN (1-430): 0: 707: 97.67
+	Hs
		933777 STK4_HUMAN (41-377): 2.43e-109: 331: 28.74		TBB4B_HUMAN (1-427): 0: 711: 100.00
+	Ce
		110167 GCK1_CAEEL (72-377): 8.25e-107: 330: 30.20		O17921_CAEEL (1-443): 0: 710: 90.75
+	Hs
		414682 CDK1_HUMAN (69-375): 8.1e-111: 328: 24.76		TBB5_HUMAN (1-429): 0: 711: 98.37
+	Ce
		110176 GCK1_CAEEL (72-377): 8.25e-107: 330: 30.20		TBB2_CAEEL (1-444): 0: 708: 90.32
+	Hs
		1023102 STK4_HUMAN (41-377): 2.43e-109: 331: 28.74		TBB6_HUMAN (1-432): 0: 706: 92.36
+	Hs
		428177 MP2K5_HUMAN (8-395): 7.03e-103: 313: 36.46		TBB5_HUMAN (1-429): 0: 711: 98.37
+	Hs
		933781 MP2K5_HUMAN (8-395): 7.03e-103: 313: 36.46		TBB4B_HUMAN (1-427): 0: 711: 100.00
+	Hs
		428081 MP2K3_HUMAN (15-388): 8.33e-102: 307: 32.47		TBB5_HUMAN (1-429): 0: 711: 98.37