Protein: RPC3
DNA-directed RNA polymerase III subunit RPC3 (RNA polymerase III subunit C3) (DNA-directed RNA polymerase III subunit C) (RNA polymerase III 62 kDa subunit) (RPC62)

Gene: RPC3, POLR3C
Organism: Homo sapiens
Interactions: 100
UniProt ID: Q9BUI4

Gene Ontology (top 5):
GO:0003697 - single-stranded DNA binding
GO:0003899 - DNA-directed RNA polymerase activity
GO:0005654 - nucleoplasm
GO:0005666 - RNA polymerase III complex
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1413118

RPC7L
DNA-directed RNA polymerase III subunit RPC7-like

8

1

Small-scale

0.972

High

186380

RPC7
DNA-directed RNA polymerase III subunit RPC7

7

1

Small-scale

0.965

High

1414272

RPC6
DNA-directed RNA polymerase III subunit RPC6

4

1

Small-scale

0.890

High

1414279

RPC5
DNA-directed RNA polymerase III subunit RPC5

5

1

High-throughput

0.720

High

430641

RPC4
DNA-directed RNA polymerase III subunit RPC4

5

1

Small-scale

0.718

High

165082

RPC1
DNA-directed RNA polymerase III subunit RPC1

1

3

High-throughput

0.691

High

911362

IMA5
Importin subunit alpha-5

4

5

High-throughput

0.689

High

180377

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

3

2

High-throughput

0.675

High

621954

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

3

1

High-throughput

0.675

High

959045

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

3

1

High-throughput

0.675

High

1414288

RPC8
DNA-directed RNA polymerase III subunit RPC8

3

1

High-throughput

0.667

High

911083

IMA1
Importin subunit alpha-1

3

5

High-throughput

0.662

High

1398347

CEP63
Centrosomal protein of 63 kDa

3

2

High-throughput

0.654

High

572177

TRI27
Zinc finger protein RFP

3

0

High-throughput

0.646

High

628838

TBP
TATA-box-binding protein

2

1

Small-scale

0.611

High

138760

IMA4
Importin subunit alpha-4

2

5

High-throughput

0.606

High

179078

IMA6
Importin subunit alpha-6

2

5

High-throughput

0.606

High

253686

IMA7
Importin subunit alpha-7

2

5

High-throughput

0.606

High

659292

SP100
Nuclear autoantigen Sp-100

2

1

High-throughput

0.606

High

983697

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

2

1

High-throughput

0.601

High

1414280

RPC2
DNA-directed RNA polymerase III subunit RPC2

2

3

Small-scale

0.601

High

1414287

RPC10
DNA-directed RNA polymerase III subunit RPC10

2

3

High-throughput

0.601

High

329100

KLHL2
Kelch-like protein 2

2

0

High-throughput

0.580

High

341845

K2C75
Keratin, type II cytoskeletal 75

2

0

High-throughput

0.580

High

685333

PAX6
Paired box protein Pax-6

2

0

High-throughput

0.580

High

800078

COIL
Coilin

2

0

High-throughput

0.580

High

1046411

UBXN1
UBX domain-containing protein 1

2

0

High-throughput

0.580

High

1081465

INCA1
Protein INCA1

2

0

High-throughput

0.580

High

1090889

TRAF2
TNF receptor-associated factor 2

2

0

High-throughput

0.580

High

1110295

KCC2B
Calcium/calmodulin-dependent protein kinase type II subunit beta

2

0

High-throughput

0.580

High

1286327

ANR23
Ankyrin repeat domain-containing protein 23

2

0

High-throughput

0.580

High

1386279

HAUS1
HAUS augmin-like complex subunit 1

2

0

High-throughput

0.580

High

1414268

CEP44
Centrosomal protein of 44 kDa

2

0

High-throughput

0.580

High

1414270

KTBL1
KATNB1-like protein 1

2

0

High-throughput

0.580

High

1414277

PICK1
PRKCA-binding protein

2

0

High-throughput

0.580

High

1414278

DISC1
Disrupted in schizophrenia 1 protein

2

0

High-throughput

0.580

High

1414282

SPN90
NCK-interacting protein with SH3 domain

2

0

High-throughput

0.580

High

1106298

ROCK1
Rho-associated protein kinase 1

1

1

High-throughput

0.573

High

1414284

TF3C4
General transcription factor 3C polypeptide 4

2

0

Small-scale

0.569

High

1063582

GOGA2
Golgin subfamily A member 2

2

1

High-throughput

0.553

High

1210146

VAX1
Ventral anterior homeobox 1

2

1

High-throughput

0.553

High

516862

RPAC2
DNA-directed RNA polymerases I and III subunit RPAC2

2

1

High-throughput

0.552

High

287472

RPC9
DNA-directed RNA polymerase III subunit RPC9

1

1

High-throughput

0.536

High

625592

CSK22
Casein kinase II subunit alpha'

1

3

High-throughput

0.536

High

912116

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

1

High-throughput

0.536

High

923529

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

1

High-throughput

0.536

High

997985

CSK21
Casein kinase II subunit alpha

1

3

High-throughput

0.536

High

1414269

MAF1
Repressor of RNA polymerase III transcription MAF1 homolog

1

1

High-throughput

0.536

High

1326066

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.513

High

417716

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.493

High

1275494

TRM1L
tRNA

1

1

High-throughput

0.489

High

185979

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

0

High-throughput

0.480

High

423041

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

157800

CTRO
Citron Rho-interacting kinase

1

1

High-throughput

0.479

High

260393

BRD4
Bromodomain-containing protein 4

1

2

High-throughput

0.479

High

386172

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

1

High-throughput

0.479

High

589567

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

696377

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

935077

TERA
Transitional endoplasmic reticulum ATPase

1

1

High-throughput

0.479

High

981059

H2B1C
Histone H2B type 1-C/E/F/G/I

1

2

High-throughput

0.479

High

1067665

EP300
Histone acetyltransferase p300

1

2

High-throughput

0.479

High

1156587

CCDC6
Coiled-coil domain-containing protein 6

1

1

High-throughput

0.479

High

1414285

NUP50
Nuclear pore complex protein Nup50

1

2

High-throughput

0.479

High

1414289

TF3C5
General transcription factor 3C polypeptide 5

1

1

Small-scale

0.479

High

1414290

TF3C3
General transcription factor 3C polypeptide 3

1

2

Small-scale

0.479

High

50991

A1L306
Tenascin-R

1

1

High-throughput

0.470

High

1414276

PRD16
Histone-lysine N-methyltransferase PRDM16

1

0

High-throughput

0.460

High

242775

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

346265

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

373023

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

414531

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

769045

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

881597

CDK8
Cyclin-dependent kinase 8

1

0

High-throughput

0.458

High

1054783

SUH
Recombining binding protein suppressor of hairless

1

0

High-throughput

0.458

High

1085821

TF3C1
General transcription factor 3C polypeptide 1

1

0

Small-scale

0.458

High

1097529

CBX3
Chromobox protein homolog 3

1

0

High-throughput

0.458

High

1356445

TF3C2
General transcription factor 3C polypeptide 2

1

0

Small-scale

0.458

High

1414267

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.458

High

1414281

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

1414283

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1367922

TENR
Tenascin-R

1

1

High-throughput

0.439

High

1141286

BRD3
Bromodomain-containing protein 3

1

4

High-throughput

0.437

High

1255325

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

132923

S28A1
Sodium/nucleoside cotransporter 1

1

0

High-throughput

0.426

High

516801

RPC22
Protein POLR1D, isoform 2

1

0

High-throughput

0.426

High

1295467

S13A5
Na(+)/citrate cotransporter

1

0

High-throughput

0.426

High

921453

SUCA
Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial

2

0

High-throughput

0.328

High

1086437

FBLN3
EGF-containing fibulin-like extracellular matrix protein 1

2

0

High-throughput

0.328

High

1256462

K0408
Uncharacterized protein KIAA0408

2

0

High-throughput

0.320

High

1389314

T3HPD
Trans-3-hydroxy-L-proline dehydratase

2

0

High-throughput

0.318

High

1007981

PO6F2
POU domain, class 6, transcription factor 2

2

0

High-throughput

0.316

High

1335260

RB8NL
RBBP8 N-terminal-like protein

2

0

High-throughput

0.316

High

1414271

ENKD1
Enkurin domain-containing protein 1

2

0

High-throughput

0.316

High

1414274

VRTN
Vertnin

2

0

High-throughput

0.316

High

1414286

LZTS1
Leucine zipper putative tumor suppressor 1

2

0

High-throughput

0.316

High

1400218

PNMA5
Paraneoplastic antigen-like protein 5

1

0

High-throughput

0.299

High

1414275

ROP1A
Ropporin-1A

1

0

High-throughput

0.299

High

275461

GA45B
Growth arrest and DNA damage-inducible protein GADD45 beta

1

0

High-throughput

0.279

Low

1414273

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

1251795

S39A5
Zinc transporter ZIP5

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025