HitPredict

Interactor 1: RPB1 (P36594)
DNA-directed RNA polymerase II subunit rpb1 (RNA polymerase II subunit 1) (RNA polymerase II subunit B1) (EC 2.7.7.6) (DNA-directed RNA polymerase III largest subunit)
Gene: RPB1

Interactor 2: RPB2 (Q02061)
DNA-directed RNA polymerase II subunit RPB2 (RNA polymerase II subunit 2) (RNA polymerase II subunit B2) (EC 2.7.7.6) (DNA-directed RNA polymerase II 138 kDa polypeptide)
Gene: RPB2

Species: Schizosaccharomyces pombe 972h-

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.82 1.00 0.909

The method score is based on:

Property Details
Experiments 9642054, 10648788, 9325316, 15743411, 14534314
Identification Methods far western blotting, pull down, affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains RNA_pol_Rpb1_1~RNA_pol_Rpb2_1, RNA_pol_Rpb1_1~RNA_pol_Rpb2_6, RNA_pol_Rpb1_1~RNA_pol_Rpb2_7, RNA_pol_Rpb1_2~RNA_pol_Rpb2_6, RNA_pol_Rpb1_2~RNA_pol_Rpb2_7, RNA_pol_Rpb1_3~RNA_pol_Rpb2_1, RNA_pol_Rpb1_3~RNA_pol_Rpb2_6, RNA_pol_Rpb1_4~RNA_pol_Rpb2_1, RNA_pol_Rpb1_4~RNA_pol_Rpb2_3, RNA_pol_Rpb1_4~RNA_pol_Rpb2_4, RNA_pol_Rpb1_4~RNA_pol_Rpb2_5, RNA_pol_Rpb1_4~RNA_pol_Rpb2_6, RNA_pol_Rpb1_5~RNA_pol_Rpb2_1, RNA_pol_Rpb1_5~RNA_pol_Rpb2_3, RNA_pol_Rpb1_5~RNA_pol_Rpb2_5, RNA_pol_Rpb1_5~RNA_pol_Rpb2_6, RNA_pol_Rpb1_5~RNA_pol_Rpb2_7
Common GO terms GO:0001055 - RNA polymerase II activity
GO:0003677 - DNA binding
GO:0005634 - nucleus
GO:0005665 - RNA polymerase II, core complex
GO:0005829 - cytosol
and 4 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 1752
Sp

1 1210
+ Dm
+ Sc
+ Hs
+ Hs
+ Sc
+ Hs
+ Pf
+ Hs
+ Hv
+ Pf
+ Hs
+ Hv
+ Hs
+ Ec
+ Nv
+ Bs
+ Hp
+ Hv
+ Mp
+ Hv

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Last updated: 15 Jul 2024